Protein Alignment Nepl21 and Mmel1

DIOPT Version :10

• Sequence 1: NP_651646.2
• Gene: Nepl21 / 43413
• FlyBaseID: FBgn0027578
• Length: 707
• Species: Drosophila melanogaster
• Sequence 2: NP_038811.2
• Gene: Mmel1 / 27390
• MGIID: 1351603
• Length: 766
• Species: Mus musculus
• Alignment Length: 725
• Identity: 200/725 - (27%)
• Similarity: 325/725 - (44%)
• Gaps: 114/725 - (15%)

  Fly    53 AEIESFMDQKADPCNDFYAFSCGNYKR------INSALS--------MQVVTTGVFETLTKGLNR 103
            |.|...|||..:||.:||.::||.:.|      .||..|        ::|:..||.|..|
Mouse    86 ARILENMDQSRNPCENFYQYACGGWLRHHVIPETNSRYSVFDILRDELEVILKGVLEDST----- 145

  Fly   104 KILKMLNTPHDSHDTPEDIKVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPL-------LEGS 161
                       |...|...|.|..|.||:....:....||.|..::...|..|:       ..|.
Mouse   146 -----------SQHRPAVEKAKTLYRSCMNQSVIEKRDSEPLLSVLKMVGGWPVAMDKWNETMGL 199

  Fly   162 SWQ-EDDFDWLNTTARMAYRYGITPIFGIEVNKDLASNTRNRIYLGQQDFPLEARSMYV-DDATA 224
            .|: |.....||:      ::....:..:.:..|..:::|:.||:.|....:.:|..|. :|...
Mouse   200 KWELERQLAVLNS------QFNRRVLIDLFIWNDDQNSSRHVIYIDQPTLGMPSREYYFQEDNNH 258

  Fly   225 VYRQKY---RNNIQRILQRYLGVKMDLAKKTA------KELIDFEVDLAQGLVDESEGLDVGELT 280
            ..|:.|   ..::..:|::    ..:|:|::|      .|:::.|..||...|.:.:..||..|.
Mouse   259 KVRKAYLEFMTSVATMLRK----DQNLSKESAMVREEMAEVLELETHLANATVPQEKRHDVTALY 319

  Fly   281 QLLTVDEIQRR-----YSPTLDIDRLLFVSMGERISD-QIYEYNNRYQQNLVEVIKRTPKRTVAN 339
            ..:.:.|:|.|     ::.||.|..:|.....|...| ::..|...|.:||.::|.....||:.|
Mouse   320 HRMDLMELQERFGLKGFNWTLFIQNVLSSVEVELFPDEEVVVYGIPYLENLEDIIDSYSARTMQN 384

  Fly   340 YIFFRLIWE--------FVETPSD---------SPEKQMKACVDLTKKYFAKNLDNMFYRRYNNE 387
            |:.:||:.:        |.|...|         ..|.:.:.||..........:.:::.:|..::
Mouse   385 YLVWRLVLDRIGSLSQRFKEARVDYRKALYGTTVEEVRWRECVSYVNSNMESAVGSLYIKRAFSK 449

  Fly   388 KSSREIDNMWRQLKSTFNETLRSSPALNWIERPTRNLAMAKLQAMTL-EVNNYAD----DN---F 444
            .|...:..:..:::|.|.:.|   ..|||::..::..|..|  ||.: |...|.|    ||   .
Mouse   450 DSKSTVRELIEKIRSVFVDNL---DELNWMDEESKKKAQEK--AMNIREQIGYPDYILEDNNKHL 509

  Fly   445 TEEFAELNLQSDDYVE----NVRYTSLLGAKQMREMLHKPAKPFEAGSQLSYTPANILIENTIKV 505
            .||::.|....|.|.|    |::..:....|::||.:.:......|....::...|   .|.|..
Mouse   510 DEEYSSLTFYEDLYFENGLQNLKNNAQRSLKKLREKVDQNLWIIGAAVVNAFYSPN---RNQIVF 571

  Fly   506 PVALLQPFYIWSDVYPNAIMFGTLASLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRR 570
            |..:|||.:...| .|.::.||.:..:||||:.|||||:||.||:.||..|||...|:.:|.::.
Mouse   572 PAGILQPPFFSKD-QPQSLNFGGIGMVIGHEITHGFDDNGRNFDKNGNMLDWWSNFSARHFQQQS 635

  Fly   571 DCFTKQYGRYVY---DGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETL 632
            .|...|||.:.:   |...:...:...||||||||:|.||.||.:|      |.:|.:|   :.|
Mouse   636 QCMIYQYGNFSWELADNQNVNGFSTLGENIADNGGVRQAYKAYLRW------LADGGKD---QRL 691

  Fly   633 PNLRYTAKQLFFISFAQSWCNDAHPSVKALQVSTDQHMPGRFRVIGSLSNFEEFSKEFNCPAGSA 697
            |.|..|..|||||::||.||....|......:.||.|.|.::||:|||.|...||:.|:||.||.
Mouse   692 PGLNLTYAQLFFINYAQVWCGSYRPEFAVQSIKTDVHSPLKYRVLGSLQNLPGFSEAFHCPRGSP 756

  Fly   698 MNPSEKCILY 707
            |:|.::|.::
Mouse   757 MHPMKRCRIW 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	M13	63..704	CDD:341056	194/710 (27%)
Mmel1	NP_038811.2	M13	97..764	CDD:341056	194/710 (27%)