DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl21 and Kel

DIOPT Version :9

Sequence 1:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_115929.3	Gene:	Kel / 23925	MGIID:	1346053	Length:	713	Species:	Mus musculus

Alignment Length:	733	Identity:	175/733 - (23%)
Similarity:	300/733 - (40%)	Gaps:	142/733 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DTPYMKELLRQAKTAEIESFM---DQKADPCNDFYAFSCGNYKRINSALSMQVVTTGVFETLTKG 100
            :||...|||        :.::   ::...||.||::|:|   ::.|.       |:..|:.||:.
Mouse    59 ETPVCMELL--------DHYLASGNRSVAPCTDFFSFAC---EKANG-------TSDSFQALTEE 105

  Fly   101 LNRKILKMLNTPHDSHDTPEDIKVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQE 165
            ...::.::|..|...|....:.|...||.||:....:.::.|..|.::|.|.|...:.  .:|..
Mouse   106 NKSRLWRLLEAPGSWHLGSGEEKAFQFYNSCMDTDAIEASGSGPLIQIIEELGGWNIT--GNWTS 168

  Fly   166 DDFDWLNTTARMAY-RYGITPIFGIEVNKDLASNTRNRIYLGQQDFPLEARSMYVDDATAVYRQK 229
            .||   |...|:.. :||..|.|...:....|......|.:.|.:|.:   .:..:....||.|.
Mouse   169 LDF---NQNLRLLMSQYGHFPFFRAYLRPHPAPPHTPIIQIDQPEFDI---LLQQEQEQKVYAQI 227

  Fly   230 YRNNIQRI--LQRYLGVKMDLAKKTAKELIDFEVDLAQGLVDESEGLDVGELTQLLTVDEIQRRY 292
            .|..:..:  |...||.....|::.|...|.|...|.|.|..:.:.....:|..::|:||:| ..
Mouse   228 LREYVTYLNRLGTLLGSNPQEAQQHASWSIVFTSRLFQFLRPQQQQQAQDKLFHVVTIDELQ-EM 291

  Fly   293 SPTLD---IDRLLFVSMGERISDQIYEYNNRYQQNLVEVIKR---TPKRTVANYIFFRLI----- 346
            :|.:|   ..:.:|..|....|..:..::..|.:|:.::::.   ..:.::.:|:...|:
Mouse   292 APAIDWLSCLQAIFTPMSLNSSQTLVVHDLDYLRNMSQLVEEGLLNHRESIQSYMILGLVDTLSP 356

  Fly   347 ---WEFVET---------------PSDSPEKQMKACVDLTKKYFAKNLDNMFYRRYNNEKSSREI 393
               .:|.|.               |..:..:.|| ||:.|..:|...|..:|.|...........
Mouse   357 ALDTKFQEARRELIQELRKLKERPPLPAYPRWMK-CVEQTGAFFEPTLAALFVREAFGPSIQSAA 420

  Fly   394 DNMWRQLKSTFNETLRSSPALNWIERPTRNLAMAKLQAMTLEV----NNYADDNFTEEFAELN-- 452
            ..::.::|......|:.   |:||...|:..|:.||..:.:|:    .....|..|:|:.::.
Mouse   421 MELFAEIKDAVIIRLKK---LSWISEETQKEALNKLAQLQVEMGAPKRAVKPDIATQEYNDIQLG 482

  Fly   453 ---LQSDDYVENVRYTSLLGAKQMREML-----HKPAK-PFEAGSQLSYTPANILIENTIKVPVA 508
               |||  ::..||   .|.|:.::..|     |:..| |:|..:..|      :.::.:..|..
Mouse   483 PSFLQS--FLSCVR---SLRARNVQSFLQPFPYHRWQKSPWEVNAYYS------ISDHMVVFPAG 536

  Fly   509 LLQPFYIWSDVYPNAIMFGTLASLIGHELIHGF------------DDSGRKFDEKGNSKDWWDEK 561
            ||||.: :...||.|:.||...|::.|||:|.|            |
Mouse   537 LLQPPF-FHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCPACD------------------- 581

  Fly   562 SSSNFLKRR-DCFTKQYGRYVYDGI-QLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGA 624
              ::.|:.. .|..:.|..:....| ....|....||.||.||:.:|:.||.|    ::....|
Mouse   582 --THVLQEALLCLERHYAAFPLPSISSFNGSHTLLENAADIGGVAIAFQAYSK----RIVEHTG- 639

  Fly   625 QDMTKETLPNLRYTAKQLFFISFAQSWCNDAHPSVKALQVSTDQHMPGRFRVIGSLSNFEEFSKE 689
                :.|||||..:..||||.|:||..|...     :.|...|.|.|...||.|.|||..:|:|.
Mouse   640 ----ELTLPNLDLSPYQLFFRSYAQVMCRGL-----SSQDPQDPHSPPSLRVHGPLSNTPDFAKH 695

  Fly   690 FNCPAGSAMNPSEKCILY 707
            |:||.|:.:|||.:|.|:
Mouse   696 FHCPRGTLLNPSARCKLW 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	169/713 (24%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	168/701 (24%)
Kel	NP_115929.3	M13	78..711	CDD:341056	168/702 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841120
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950