Protein Alignment Nepl21 and ECE1

DIOPT Version :10

• Sequence 1: NP_651646.2
• Gene: Nepl21 / 43413
• FlyBaseID: FBgn0027578
• Length: 707
• Species: Drosophila melanogaster
• Sequence 2: XP_011539174.1
• Gene: ECE1 / 1889
• HGNCID: 3146
• Length: 778
• Species: Homo sapiens
• Alignment Length: 712
• Identity: 207/712 - (29%)
• Similarity: 316/712 - (44%)
• Gaps: 111/712 - (15%)

  Fly    52 TAEIESFMDQKADPCNDFYAFSCGNYKRINSALSMQVVTTGVFETLTKGLNRKILKMLNTPHDSH 116
            |:.|.|.||...|||:||::::||.:.:.|...... ...|.|..|.:. |:.|:|.|.....:.
Human   116 TSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGH-SRWGTFSNLWEH-NQAIIKHLLENSTAS 178

  Fly   117 DTPEDIKVKHFYESCLQIKELNSTYSEKLKRLIAEFG----TMPLLEGSSWQEDDFDWLNTTARM 177
            .:..:.|.:.:|.:|:....:....::.|..||...|    |.|      |.:|:|.  :|...:
Human   179 VSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGP------WAKDNFQ--DTLQVV 235

  Fly   178 AYRYGITPIFGIEVNKDLASNTRNRIYLGQQDFPLEARSMYVDDATAVYRQKYRNNIQRILQRYL 242
            ...|..:|.|.:.|:.|..::..|.|.:.|....|.:|..|::        |..|  :::|..||
Human   236 TAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLN--------KTEN--EKVLTGYL 290

  Fly   243 GVKMDLAK-----------KTAKELIDFEVDLAQGLVDESEGLDVGELTQLLTVDEIQR-----R 291
            ...:.|.|           ...::::|||..||...:.:.:..|...:...:|..|:|.     .
Human   291 NYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAIN 355

  Fly   292 YSPTLDIDRLLFVSMGERISDQIYEYNNRYQQNLVEVIKRTPKRTVANYIFFRLIWEFVETPS-- 354
            :.|.|:   .:|..:....|:.|..|:..|.:.:..:|..|.:..:.||    :||..|...|
Human   356 WLPFLN---TIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNY----MIWNLVRKTSSF 413

  Fly   355 ------DSPEKQM--------------KACVDLTKKYFAKNLDNMFYRRYNNEKSSREIDNMWRQ 399
                  |:.||.|              |.||..|:......|..||.:....|.|......:..:
Human   414 LDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILE 478

  Fly   400 LKSTFNETLRSSPALNWIERPTRNLAMAKLQAMTLEVNNYADDNFTEEFAELNLQSDDYV----- 459
            :|..|.|:|.:   |.|::..||..|..|..|:   .|.....||..:..||:...:||.
Human   479 IKKAFEESLST---LKWMDEETRKSAKEKADAI---YNMIGYPNFIMDPKELDKVFNDYTAVPDL 537

  Fly   460 --ENV----RYTSLLGAKQMREMLHKPAKPFEAGSQLSYTPANI-----LIENTIKVPVALLQ-P 512
              ||.    .::..:.|.|:|:..::        .|.|.||..:     ..:|.|..|..:|| |
Human   538 YFENAMRFFNFSWRVTADQLRKAPNR--------DQWSMTPPMVNAYYSPTKNEIVFPAGILQAP 594

  Fly   513 FYIWSDVYPNAIMFGTLASLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQY 577
            ||..|.  |.|:.||.:..::||||.|.|||.||::|:.||.:.||...|...|.::.:|..:||
Human   595 FYTRSS--PKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQY 657

  Fly   578 GRYVYDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQL 642
            ..|..:|..:.......||||||||::.||.||:.|.:.     |||:    .:||.|..|..||
Human   658 SNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKK-----NGAE----HSLPTLGLTNNQL 713

  Fly   643 FFISFAQSWCNDAHPSVKALQVSTDQHMPGRFRVIGSLSNFEEFSKEFNCPAGSAMNPSEKC 704
            ||:.|||.||:...|......:.||.|.|.||||||||||.:|||:.|.||.||.|||..||
Human   714 FFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKC 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	M13	63..704	CDD:341056	200/699 (29%)
ECE1	XP_011539174.1	M13	127..776	CDD:341056	202/701 (29%)