DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl21 and Phex

DIOPT Version :9

Sequence 1:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_035207.1	Gene:	Phex / 18675	MGIID:	107489	Length:	749	Species:	Mus musculus

Alignment Length:	729	Identity:	187/729 - (25%)
Similarity:	319/729 - (43%)	Gaps:	87/729 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KQDTPYMKELLRQAKTAEIESFMDQKADPCNDFYAFSCGNYKRINSALSMQVVTTGVFETLTKGL 101
            ||:.....|.:..|  |.|.|.::...|||.:|:.|:|..:.. |:.:...:.:.||:..|...:
Mouse    50 KQEYCLKPECIEAA--AAIMSKVNLSVDPCENFFRFACDGWIS-NNPIPEDMPSYGVYPWLRHNV 111

  Fly   102 NRKILKML-NTPHDSHDTPEDIKVKHFYESCLQIKELNSTYSEKLKRLI--AEFGTMPLLEGS-- 161
            :.|:..:| .:.....||....|.|..|.||:..|.:....::.|..::  :.| ..|:||.:
Mouse   112 DLKLKALLEKSVSRRRDTEAVQKAKILYSSCMNEKAIEKADAKPLLHILRHSPF-RWPVLEANIG 175

  Fly   162 ---SWQEDDFDWLNTTARMAYRYGITPIFGIEVNKDLASNTRNRIYLGQQDFPLEARSMYVDDAT 223
               .|.|..|..|.|.|....:|..:....:.|:.|..::..:.:.|.|....|..|..::|:.|
Mouse   176 PEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDFLDNTT 240

  Fly   224 AVYRQKYRNNIQRIL---QRYLGVKMDLAKKTAKELIDFEVDLAQGLVDE----SEG----LDVG 277
            ..  :.||:.:.:.:   ...||.....|:...|.::..|:.:|:.::..    ||.    :::.
Mouse   241 EA--KSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNIS 303

  Fly   278 ELTQLLTVDEIQRRYSPTLD--------IDRLLFVSMGE-RISDQIYEYNNRYQQNLVEVIKRTP 333
            ||:.::          |..|        ||..|:..:.: ..|:.:.....:|.::|..::....
Mouse   304 ELSAMI----------PQFDWLGYIKKVIDTRLYPHLKDIGPSENVVVRVPQYFKDLFRILGAER 358

  Fly   334 KRTVANYIFFRLIWEFVETPSDSPEKQMK-------------------ACVDLTKKYFAKNLDNM 379
            |:|:|||:.:|:::..:  |:.|...|.:                   .||:..:......:..|
Mouse   359 KKTIANYLVWRMVYSRI--PNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKM 421

  Fly   380 FYRRYNNEKSSREIDNMWRQLKSTFNETLRSSPALNWIERPTRNLAMAKLQAMTLEVNNYA---- 440
            |...:..|.....::.:...::..|.:.|....  .|::..|:..|..|.:|:..:| .|.
Mouse   422 FVNVHFQEDKKEMMEELIEGVRWAFIDMLEKEN--EWMDAGTKRKAQEKARAVLAKV-GYPEFIM 483

  Fly   441 -DDNFTEEFAELNLQSDDYVENVRYTSLLGAKQMREMLHKPAKPFEAGSQLSYTPANILIE---N 501
             |....|:...:.....||..||..|....|:.....|.|.....|..:  :.|..|....   |
Mouse   484 NDTYVNEDLKAIKFSESDYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFT--NPTTVNAFYSASTN 546

  Fly   502 TIKVPVALLQPFYIWSDVYPNAIMFGTLASLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNF 566
            .|:.|...||..:.|...||.::.:|.:..::|||..||||::|||:|:.||...||..:|...|
Mouse   547 QIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSVESEEKF 611

  Fly   567 LKRRDCFTKQYGRYVYD--GIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTK 629
            .::..|...||..|.:.  |:.:|......||||||||:|.|:.|||||..::      .|.:.:
Mouse   612 KEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDR------RQGVEE 670

  Fly   630 ETLPNLRYTAKQLFFISFAQSWCNDAHPSVKALQVSTDQHMPGRFRVIGSLSNFEEFSKEFNCPA 694
            ..||.:.:|..||||:|:|...||...|.....||....|.|.:|||.|::||||||.|.||||.
Mouse   671 PLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPR 735

  Fly   695 GSAMN-PSEKCILY 707
            .|.|| .::.|.|:
Mouse   736 NSTMNRGADSCRLW 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	180/707 (25%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	178/698 (26%)
Phex	NP_035207.1	PepO	67..741	CDD:226118	178/700 (25%)
Phex	NP_035207.1	M13	74..747	CDD:189000	178/699 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020