Protein Alignment Nepl21 and nep-23

DIOPT Version :10

• Sequence 1: NP_651646.2
• Gene: Nepl21 / 43413
• FlyBaseID: FBgn0027578
• Length: 707
• Species: Drosophila melanogaster
• Sequence 2: NP_503004.2
• Gene: nep-23 / 178472
• WormBaseID: WBGene00013785
• Length: 714
• Species: Caenorhabditis elegans
• Alignment Length: 801
• Identity: 185/801 - (23%)
• Similarity: 322/801 - (40%)
• Gaps: 212/801 - (26%)

  Fly    12 LLCICIAGHV-------LSAMVAAAPTSEE-----------DLKQDTP-YMKELLRQAKTA---- 53
            ::.|.|.|.|       |....|.|.:|:|           .|:|..| ::|:.:.|....
 Worm    21 IVVIAIFGTVVIWKIDKLELWEAEALSSQESMLGELKVAVTSLEQHRPGHLKKNVCQTPECITLA 85

  Fly    54 -EIESFMDQKADPCNDFYAFSCGNYKR--INSALSMQ--VVTTGVFETLTKGLNRKILKMLNTPH 113
             ::.::.|..||||::||...||....  :.|.|:.:  ::...:.||:|   |||:     ||.
 Worm    86 HQLHNYHDPSADPCDNFYQSVCGKQHEHSLKSGLAKKHLILRNLIRETIT---NRKV-----TPT 142

  Fly   114 DSHDTPEDIKVKHFYESCLQIKELNSTYS------EKLKRLIAEFGTMPLLEGS-SWQEDDFDWL 171
            ...:.    :::.|:..|.:.:..||:..      ..:.|.:...|:.|  .|| :|.|.||:
 Worm   143 SKSEN----EMRKFHGICSKYQRANSSSDIAQQALRDIFRDVQSIGSWP--AGSRNWNESDFN-- 199

  Fly   172 NTTARMAYRYGITPIFGIEVNKDLASNTRNRIYLGQQDFPLEARSMYVDDATAVYRQKYRNNIQR 236
                               :|:.|    .|.:.|||::|.|...|....|...:..:::|.|..:
 Worm   200 -------------------LNEML----NNLVKLGQRNFGLFQISFKYRDQLLISAEEHRRNYSK 241

  Fly   237 ILQRYLGVKMDLAKKTAKELIDFEVDLAQGLVDES-------EG-------------LDVGELTQ 281
            :....|.:              ||.:   |||.:.       ||             ||..:..:
 Worm   242 LEPTILNI--------------FETN---GLVPDRIQLLKDLEGFASLEALLKNHYYLDNMDKMK 289

  Fly   282 LLTVDEIQRRYSPTLDIDRLL--FVSMGER------------ISDQIYEYNNRYQQNLVEVIKRT 332
            ...:|::    .|::|...|:  .:|.|:.            ::..::...|   .||..:|..|
 Worm   290 PAVLDDL----VPSVDFMGLVKAMISPGKEHLMPKIELKTSVLNQTLFNDEN---MNLEAIILDT 347

  Fly   333 PKRTVANYIFFRLIWEFVETPSD-----SPEKQMKACVDLTKKYFAKNLDNMFYRRYNNEKSSRE 392
            ||||:|||    ||:.|:::..|     :..::...|.|....|..:....:|.|.|.::::...
 Worm   348 PKRTLANY----LIFNFIDSSLDHLVFETTSQKGNTCEDKVITYLPRASLRVFIRNYVDKENRDL 408

  Fly   393 IDNMWRQLKSTFNETLRSSPALNWIERPTRNLAMAKLQAMTLEVNNYADDNFTEE-------FAE 450
            |..:..:.:...:..:::|   .|::..::.||:.|:.||. ::..|.|  |.|.       |..
 Worm   409 ITQLAEKTRIALHTLVQNS---TWLKAESKQLALDKINAMG-KMIGYPD--FFEPPGTLDGMFKN 467

  Fly   451 LNLQSDDYVENVRYTSLLGAKQMREMLHK---------PAKP----FEAGSQLSYTPANILIENT 502
            |||.|.|    ..||:|  .|..|..:.:         |..|    ||..:.. |.|.|.|
 Worm   468 LNLDSSD----TYYTAL--NKLERYFVEQKMDYFAEETPLDPDLRVFEMNAYY-YIPGNQL---- 521

  Fly   503 IKVPVALLQPFY---IWSDVYPNAIMFGTLASLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSS 564
                 ..|.||:   ::...||:.:......::||||:.|.|.........:|. :.|...:..:
 Worm   522 -----NFLAPFFDDPMFDSTYPDYVNIAMSGNIIGHEMGHAFGPHAILRTVRGR-EVWMKPEELA 580

  Fly   565 NFLKRRDCFTKQYGRY-------VYDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPN 622
            .:..|..|...||..|       |:||.::.:     |.:|||.|..:::..::     .|.|.|
 Worm   581 EYESRAQCLANQYSEYDDPDFGRVFDGGKVID-----ELVADNIGREVSWKMFK-----SLDLTN 635

  Fly   623 GAQDMTKETLPNLRYTAKQLFFISFAQSWCNDAHPSVKALQVSTDQHMPGR-FRVIGSLSNFEEF 686
            ..:.:..|.     |...||:|...|.:.|. .| :::.|:.|.:...|.: |||.|..:|..||
 Worm   636 ATRIIGFED-----YDIDQLYFRVGALTHCT-PH-AMRDLKGSIESSHPRKAFRVNGVYANLPEF 693

  Fly   687 SKEFNCPAGSAMNPSEKCILY 707
            ::.||||.||.|||.:||.::
 Worm   694 ARAFNCPTGSPMNPRKKCDMF 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	M13	63..704	CDD:341056	168/721 (23%)
nep-23	NP_503004.2	M13	96..711	CDD:341056	168/721 (23%)