DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl21 and nep-1

DIOPT Version :9

Sequence 1:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_496490.2	Gene:	nep-1 / 174787	WormBaseID:	WBGene00013926	Length:	754	Species:	Caenorhabditis elegans

Alignment Length:	778	Identity:	198/778 - (25%)
Similarity:	332/778 - (42%)	Gaps:	133/778 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VLSAMVAAAP-------------TSEEDLKQDTPYMKELLRQAKTAEIESFMD-----QKA---- 63
            :|...|.|.|             |:.||.......::|..:.....:.|.:.:     ||:
Worm    19 ILCGTVDALPRAPYFNDDINKTTTTSEDKTVGNTVVEEEKKTYTVGDSEGYQEASRLLQKSLNLS 83

  Fly    64 -DPCNDFYAFSCGNYKRINSALSMQVVTTGVFETLTKGLNRKIL---KMLNTPHDSHDTPEDIK- 123
             |||:||:.::|..:  ::|......:|:....|.|:   .|:|   :.|...:.|..|.:.|.
Worm    84 LDPCDDFFEYACRAW--VDSHPIPDDLTSYSQFTATR---EKVLAEMRKLYEDNTSIPTSKSIAL 143

  Fly   124 VKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQEDDFDWLNTTARMAYRYGITPIFG 188
            :|..|.:|:..::.|:..:..|...|..:|..|::....|:|..||.....:.......::..|.
Worm   144 IKQIYNTCMDTEKHNAVGARDLLEKIKTYGYWPMVHNEKWRESTFDLTKLLSNTIQSRDVSVFFD 208

  Fly   189 IEVNKDLASNTRNRIYLGQQDFPL--EARSMYVDDATAVYRQKYRNNIQRILQ------RYLGVK 245
            ....:|..:.:|..:...|....|  ..|..|:|:      :||...::...:      ||....
Worm   209 FGPAEDSRNVSRRLLSFDQGSLGLGYSTRDYYLDE------KKYEKQMKAYRKYTIGKVRYYTED 267

  Fly   246 MDLAKKTAK------ELIDFEVDLAQGLVDESEGLDVGELTQLLTVDEIQRRYSPTLDIDRL--- 301
            ..:|...:|      |:|.||.:.||.||.|.:..:..:|..:...|:: :.|...:|..:|
Worm   268 AGMAVNESKIESDVDEIIAFEKEWAQILVAEEDRRNYTKLYNVRRFDDL-KEYMSIIDWKKLTLS 331

  Fly   302 ---LFVSMGERISDQIYEYNNRYQQNLVEVIKRTPKRTVANYIFFRLIW---------------- 347
               ..|....:.:..|...:..|.|.:..:::.|..|.|.|||..|  |
Worm   332 TTPFLVHSYLKTNPSIIISDVEYLQKMNTLLQNTDPRIVTNYILLR--WAGSWSQEIGKKYEDLQ 394

  Fly   348 -EFVETPSDSPEKQ--MKACVDLTKKYFAKNLDNMFYRRYNNEKSSREIDNMWRQLKSTFNETLR 409
             ||........::|  .|.||.......:....:|:.|:|.:..:.....:|...|:..|...:.
Worm   395 QEFAFQMYGRKQRQPRWKDCVSSAGGKLSYASGSMYVRKYFDANAKNTTLDMITDLQEAFRNMMH 459

  Fly   410 SSPALNWIERPTRNLAMAKLQAMTLEVNNYADDNFTEE----------------FAELNLQSDDY 458
            ::   :|::..|:..|:.|...|..:: .|.|....:|                |::|..:|..:
Worm   460 AN---DWMDAETKKYALEKADQMLKQI-GYPDFILNDEKLDDWYKGLEGAPEDSFSQLVEKSIQW 520

  Fly   459 VENVRYTSLLGAKQMREMLHKPAKPFEAGSQLS-----YTPANILIENTIKVPVALL-QPFYIWS 517
            ..|..|..||          :|...||..|..:     |:|.    .|.|..|..:| |||:
Worm   521 RNNFYYRRLL----------EPVNRFEFISSAAVVNAFYSPT----RNAIAFPAGILQQPFF--- 568

  Fly   518 DV-YPNAIMFGTLASLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYV 581
            |. :|.|:.:|.:.::||||:.|||||:||:||..||.:||||..:||.|.:|..|..:||....
Worm   569 DARFPKALNYGGIGAVIGHEITHGFDDTGRQFDNVGNLRDWWDNTTSSKFNERTQCIIEQYADVK 633

  Fly   582 YDG--IQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFF 644
            ..|  :::.....|.||||||||::.|:.||:.:.|.     :|.|:.......:|  |.:||||
Worm   634 LRGTDLRINGKLTQGENIADNGGIKQAFKAYKSYLEK-----HGGQEARLPQFESL--TNEQLFF 691

  Fly   645 ISFAQSWCNDAHPSVKALQVSTDQHMPGRFRVIGSLSNFEEFSKEFNCPAGSAMNPSEKCILY 707
            :.:||.||....|..|.|.:.||.|.|...||...|:|..||::.|.|||||.|||:::|:::
Worm   692 VGYAQVWCGAKTPETKTLLLLTDPHSPETARVNTVLTNQPEFAEAFKCPAGSPMNPTKRCVVW 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	189/727 (26%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	186/713 (26%)
nep-1	NP_496490.2	PepO	80..754	CDD:226118	187/715 (26%)
nep-1	NP_496490.2	M13	85..751	CDD:189000	186/707 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160146
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3745
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.900