Protein Alignment Nepl21 and nep-26

DIOPT Version :10

• Sequence 1: NP_651646.2
• Gene: Nepl21 / 43413
• FlyBaseID: FBgn0027578
• Length: 707
• Species: Drosophila melanogaster
• Sequence 2: NP_001022540.1
• Gene: nep-26 / 174593
• WormBaseID: WBGene00014171
• Length: 807
• Species: Caenorhabditis elegans
• Alignment Length: 766
• Identity: 174/766 - (22%)
• Similarity: 325/766 - (42%)
• Gaps: 152/766 - (19%)

  Fly    31 TSEEDLKQDTPYMKELLRQAKTAEIESFMDQKADPCNDFYAFSCGNYKRINSALSMQVVTTGVFE 95
            ||||.:...:..:|.             :||..:||::||.|:||.:  ||.:::::..:.....
 Worm   105 TSEECVMTASRLLKR-------------VDQSVEPCDNFYQFACGGW--INQSVNLKYDSWNTLY 154

  Fly    96 TLTKGLNRKILKMLNTPHD-SHDTPEDI---KVKHFYESCLQIKELNSTYSEKLKRLIAEF-GTM 155
            ...:..:.:|::.::..:| |:..|.:.   .....||.|:....|..|.....:|.:.|. |.|
 Worm   155 ETQRTAHDQIVQAMHKINDGSYPLPTNAGERAAAKMYEQCMDTDTLEQTGLHLWERFVDELGGWM 219

  Fly   156 P-LLEGSSWQEDDFD-------------WLNTTARMAYRYGITPIF--GIEVNKDLASNTRNRIY 204
            | |..|:..||:.|:             .:......|:.|.:.|:|  |:|||           |
 Worm   220 PELKNGALEQEESFEIELDEDEKKRRRFEIEDIILSAFNYSVFPLFWAGVEVN-----------Y 273

  Fly   205 LGQQDFPLEARSMYVDDATAVYRQKYRNN----------------IQRILQR-------YLG--- 243
            |..::..:   ::|......:..:||..|                :.|.||:       .||
 Worm   274 LNSKEHLI---TIYEQLPILLAPEKYHYNKELTPEMIYGKMEGPPVTRALQQVGEELSAVLGFDS 335

  Fly   244 ----VKMDLAKKTAKELIDFEVDLAQGLVDESEGLDVGELTQLLTVDEIQRRYSPTLDIDRLLFV 304
                |:|.:|...   .:::::.:| |.....|..:...:..|..:.||    :|.::....|..
 Worm   336 TDEKVRMMIANMI---YLEYQITMA-GSTFYKEKKERYTVVMLRELQEI----APAINWHYFLSR 392

  Fly   305 SMGERISDQ---IYEYNNRY---QQNLVEVIK--RTPKRTVANYIFFR----------------L 345
            .:||.:|..   ..:...::   ...:||.:|  |:....:.||:.::                |
 Worm   393 LVGENLSHSEPIALKTGTQWIPILSAIVEKLKQSRSGVAVLKNYVKWKTIMFHLAYASPKCRDGL 457

  Fly   346 IWEFVETPSDSPEKQMKACVDLTKKYFAKNLDNMFYRRY----NNEKSSREIDNMWRQLKSTFNE 406
            :|..|...|.:..::.:.||......|..:|.::. |:.    :.||:.:.:.|:..:::..:.|
 Worm   458 LWMAVSLYSGAASQRKEFCVLRLSGIFPLSLPSIL-RKIDGIDHTEKNVKAVQNIADRIQEKYEE 521

  Fly   407 TLRSSPALNWIERPTRNLAMAKLQAMTLEVNNYADDNFTEEFAELNLQSDDYVENVRYTSLLGAK 471
            .:|||...:  :|.||...:.|:..||..:.  ..|....:: |:..::....:.:.::.:||:.
 Worm   522 MVRSSNLFS--DRETRENVIDKVNNMTKFIG--FPDAMRSDY-EMEKEAVRLHDTLFWSMVLGSS 581

  Fly   472 QM-REMLHKPAKPFEAGSQLS-----YTPANILIENTIKVPVALLQPFYIWSDVYP-NAIMFGTL 529
            .: :|.|.:...|.:..|.:.     ..||:....|.:::|...|:..|  :|.:. :...:..:
 Worm   582 SVYKERLQRLRLPVDPRSWVDTRPAISVPAHNYERNLVQIPFDSLRLPY--ADEHQLDFANYAGI 644

  Fly   530 ASLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYV--YDGIQLKESTA 592
            .::|||||.|.||..|:.....||...||...|...|..|..||.|||...:  :|....||..
 Worm   645 GTIIGHELTHAFDGQGKLHGPTGNLGVWWSTDSIREFKAREQCFVKQYAGLMDSHDMNAAKEGL- 708

  Fly   593 QSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNL-RYTAKQLFFISFAQSWCNDAH 656
             .|||||..|:::||.|::.         ||.|:..:  :|.| :|:..||||:::.|.||
 Worm   709 -YENIADQVGLKVAYEAWKS---------NGNQNSGR--MPGLEKYSQDQLFFLAYTQGWC---- 757

  Fly   657 PSVKALQVSTDQHMPGRFRVIGSLSNFEEFSKEFNCPAGSAMNPSEKCILY 707
             ::::.......||..|.|::|||.|..||:..:.|.:.|.|||.:||.::
 Worm   758 -ALRSKSYKLQPHMEERIRMLGSLQNSPEFASAWKCSSESFMNPPDKCSIW 807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	M13	63..704	CDD:341056	165/729 (23%)
nep-26	NP_001022540.1	M13	124..805	CDD:341056	166/730 (23%)