DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl21 and nep-5

DIOPT Version :9

Sequence 1:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_001364754.1	Gene:	nep-5 / 173933	WormBaseID:	WBGene00017393	Length:	694	Species:	Caenorhabditis elegans

Alignment Length:	710	Identity:	156/710 - (21%)
Similarity:	275/710 - (38%)	Gaps:	166/710 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 MKELLRQAK-----TAEIESFMDQKADPCNDFYAFSCGNYKRINSALSMQVVTTGVFETLTKGLN 102
            |.:|..|.|     :||:...||...:||.:|:...|..                 |....|...
Worm   103 MLDLPCQTKECVKYSAELLELMDSSVNPCENFHHHVCNG-----------------FNPRKKDFE 150

  Fly   103 RKILKMLNTPHDSHDTPEDIK----VKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSW 163
            | ::|::|.    .:.|:..|    |:.....|...|........:|..:|......||| .:||
Worm   151 R-LMKLINI----QEKPDHRKAVNVVRRMLSKCAMGKTEEIHQVGRLSSIILPGLPFPLL-NNSW 209

  Fly   164 QE--DDFDWLNTTARMAYRYGITPIFG--IEVNKDLASNTRNRIYLGQQDFPLEARSMYV--DDA 222
            .:  |.....|::...:|.: :|.|..  |..|.|.|.      ::|.:.......|::|  ..:
Worm   210 TKPSDPISTSNSSTTYSYPF-LTKILAHIILHNPDDAG------FVGIKPSSDSEFSLFVVKPFS 267

  Fly   223 TAVYRQKYRNNIQRILQRYLGVKMDLAKKTAKE-----LIDFEVDLAQGLVD------ESEGLDV 276
            ..:...|:||            ..|:.|:.|.|     :||.|.|..:.|.|      :.|.::.
Worm   268 PVLTNFKFRN------------MYDILKRNAPESSTNGMIDLEFDRQRQLNDVIKLQTKLEKIEF 320

  Fly   277 GELTQLLTVDEIQRRYSPTLDIDRLL--FVSMG-ERISDQIYEYNNRYQQNLVEVIKRTPKRTVA 338
            ....:::.:.||||: .|.:|..||:  ::..| ..:.:::|.:|..|.:.:..:|..||..|:.
Worm   321 KADPEVVNLTEIQRQ-MPIIDWKRLIDSWIPNGYAHLKEKVYGFNTSYYEEINAIISSTPSETIY 384

  Fly   339 NYIFFRLIWEFVETPSDSPEKQMKACVDLTKKYFAKNLDNMFYRR-----------YNNEKSSRE 392
            |::|.|..::|:.|.                  .|.:|::....:           |.:|:.  |
Worm   385 NFLFLRFSFKFLRTE------------------VASDLEDTCLHQLSTTIPGKIVLYGSEEP--E 429

  Fly   393 IDNMWRQLKSTFNETL-RSSPALNWIERPTRNLAMAKLQAMTLEVNNYADDNFTEEFAELNLQSD 456
            ..|:...:..|..:.| ||...|.|::......|..|.. .|..|..:..::..:|.........
Worm   430 ALNLLNGMLHTIKDQLKRSLATLKWMDSRGIEEAQKKFN-KTKTVFGFTGEDLIDELVGKITPES 493

  Fly   457 DYVENVRYTSLLGAKQMREMLHKPAKPFEAGSQLSYTPANILIENTIKVPVALLQ-PFYIWSDVY 520
            :|:..::...|...:.|.:.:.:........|::.|:    :.:|.|.:..|||. ||  .|...
Worm   494 NYISTLQNVLLWQTRNMFKSVAENNVTVFLNSEVFYS----VEKNEITISRALLHYPF--MSANL 552

  Fly   521 PNAIMFGTLASLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYDGI 585
            ||...|.|:||.|..::||.||:.||.:|..||.::||:.::...|.....||         ||:
Worm   553 PNYTNFATIASKILPQMIHIFDERGRFYDSDGNHRNWWNTETERYFQIIVQCF---------DGM 608

  Fly   586 QLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKE---TLPNLRYTAKQ-LFFIS 646
            .        :|:. ...:.:.:.||               |.|||   |||.::.::.: |||.|
Worm   609 M--------QNVF-GVSVSIGWNAY---------------DSTKEPYATLPGIQQSSDEALFFYS 649

  Fly   647 FAQSWCNDAHPSVKALQVSTDQHMPGRFRVIGSLSNFEEFSKEFNCPAGSAMNPSEKCIL 706
            ..::.|.....:|..                 :|::..:|:..|.|..|:.|||..||.|
Worm   650 MVKTMCTSDPDNVNE-----------------ALASVPQFNSAFKCNNGTKMNPPTKCKL 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	150/691 (22%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	145/681 (21%)
nep-5	NP_001364754.1	GluZincin	128..691	CDD:417498	146/682 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020