DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl21 and nep-12

DIOPT Version :9

Sequence 1:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_001364537.1	Gene:	nep-12 / 173824	WormBaseID:	WBGene00017842	Length:	832	Species:	Caenorhabditis elegans

Alignment Length:	727	Identity:	200/727 - (27%)
Similarity:	326/727 - (44%)	Gaps:	106/727 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 TPYMKELLRQAKTAEIESFMDQKADPCNDFYAFSCGNY--KRINSALSMQVVTTGVFETLTKGLN 102
            ||   |.:|.|  |...:.|::.|:||.|||.|:||.|  :::.:....:|.   |...:.|.::
Worm   153 TP---ECIRLA--ASYLNNMNRDANPCEDFYEFACGKYATRKVIAEHEKKVT---VLSEMKKEMD 209

  Fly   103 RKILKMLNTPHDSHDTPEDIKVKHFY-ESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQED 166
            |.:..:|... ...:|...:|:...| :||:.....:....:.|..:|:..|..|||..:.:...
Worm   210 RHLKDILEKT-SRENTTRSMKLAQIYFDSCMDEFSQDDLGVQPLMSMISNLGGWPLLTNARFDSI 273

  Fly   167 DFDWLNTTARMAYRYGITPIFGIEVNKDLASNTRNRIYLGQQDFPLEARSMYVD-DATAVYRQKY 230
            ||.|......:|. ||:..||.:.|:.....:.:|.:........||.:..|.: .::.||.|.|
Worm   274 DFQWEVLAGHLAL-YGVDGIFRVFVHSSFDDSDKNVLMFSPPKLFLEKKKFYREVPSSNVYLQYY 337

  Fly   231 RNNIQRILQRYLGVKMD----LAKKTAKELIDFEVDLAQGLVDESEGLDVGELTQLLTVDEIQRR 291
            |..|..:|. .|||.|:    :.:....::||||..:| .|.......:...:..::|..|.:|:
Worm   338 RQYILSLLS-LLGVDMEDETGVIEYQVDDIIDFERRIA-NLTRIELSRNHSSINNMITFGEFKRK 400

  Fly   292 YSPTLDIDRLLFVS------------MGERISDQIYEYNNRYQQNLVEVIKRTPKRTVANYIFFR 344
            |      |::.:.:            |.:.:...:.:.|  |..||..:||..|..::.|::.:.
Worm   401 Y------DKINWDAFFNEEMRGNLGRMPDSLVINVVDVN--YFDNLYSLIKSKPLSSINNFLMWC 457

  Fly   345 LIWEF-------------------VETPSDSPEKQMKACVDLTKKYFAKNLDNMFYRRYNNEKSS 390
            |:..:                   ....||.|  ..:.||...::..|..|...:.:::..:|..
Worm   458 LVSNYDMYLPAKYRKPMLDFRQKMYGVSSDDP--LWEVCVGEVRENLAMPLSTEYAQKFFTKKDK 520

  Fly   391 REIDNMWRQLKSTFNETLRSSPALNWIERPTRNLAMAKLQAMTLEVNNYADDNFTE-----EFAE 450
            ...::|.|.||....:||.::   :||:..||..|:.||.||..:: .:.|....|     .:|.
Worm   521 LVAEDMIRDLKKAMEQTLLNA---DWIDESTREAALMKLDAMGHKI-GFPDSLLNETAVLLPYAG 581

  Fly   451 LNLQSDDYVENVRYTSLLGAKQMREMLHKP------AKPFEAGSQLSYTPANILIENTIKVPVAL 509
            :.|.::.|.:|.........:.....||:.      |.|..|.....|...|.:|     .|..:
Worm   582 VRLTANQYFDNAISLKKAAYRDALSKLHRTPSLIDWASPIIAVDAFHYFTGNEII-----FPAGI 641

  Fly   510 LQ-PFYIWSDVYPNAIMF---GTLASLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRR 570
            || |.::     |:|..|   |.:...||||:.||:||.|.::|:|||.:.||..::.:.|.|::
Worm   642 LQFPMFV-----PDAPAFSNYGAIGMGIGHEITHGYDDLGAQYDDKGNLRGWWHTETMTTFQKKK 701

  Fly   571 DCFTKQYGRYV--YDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKET-- 631
            .||..|||..:  ..|.::.......||||||||:|:|:.||      ||     ..|..|||
Worm   702 QCFVAQYGSKIEPQTGRKVDGKMTIGENIADNGGLRVAFQAY------QL-----RSDREKETRR 755

  Fly   632 LPNLR-YTAKQLFFISFAQSWCNDAHPSVKALQVSTDQHMPGRFRVIGSLSNFEEFSKEFNCPAG 695
            ||.|. ::..||||:::|.:||....||.....:.||.|..|.|||...|.|...|||||:||.|
Worm   756 LPGLTDFSPNQLFFLAYANTWCEALKPSAIDHIMDTDVHSLGMFRVNVPLQNLPAFSKEFDCPIG 820

  Fly   696 SAMNPSEKCILY 707
            |.|||.|||.::
Worm   821 SPMNPFEKCRIW 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	194/708 (27%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	191/699 (27%)
nep-12	NP_001364537.1	M13	171..830	CDD:341056	192/700 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3745
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.970