Protein Alignment Nepl21 and nep-12

DIOPT Version :10

• Sequence 1: NP_651646.2
• Gene: Nepl21 / 43413
• FlyBaseID: FBgn0027578
• Length: 707
• Species: Drosophila melanogaster
• Sequence 2: NP_001364537.1
• Gene: nep-12 / 173824
• WormBaseID: WBGene00017842
• Length: 832
• Species: Caenorhabditis elegans
• Alignment Length: 727
• Identity: 200/727 - (27%)
• Similarity: 326/727 - (44%)
• Gaps: 106/727 - (14%)

  Fly    40 TPYMKELLRQAKTAEIESFMDQKADPCNDFYAFSCGNY--KRINSALSMQVVTTGVFETLTKGLN 102
            ||   |.:|.|  |...:.|::.|:||.|||.|:||.|  :::.:....:|.   |...:.|.::
 Worm   153 TP---ECIRLA--ASYLNNMNRDANPCEDFYEFACGKYATRKVIAEHEKKVT---VLSEMKKEMD 209

  Fly   103 RKILKMLNTPHDSHDTPEDIKVKHFY-ESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQED 166
            |.:..:|... ...:|...:|:...| :||:.....:....:.|..:|:..|..|||..:.:...
 Worm   210 RHLKDILEKT-SRENTTRSMKLAQIYFDSCMDEFSQDDLGVQPLMSMISNLGGWPLLTNARFDSI 273

  Fly   167 DFDWLNTTARMAYRYGITPIFGIEVNKDLASNTRNRIYLGQQDFPLEARSMYVD-DATAVYRQKY 230
            ||.|......:|. ||:..||.:.|:.....:.:|.:........||.:..|.: .::.||.|.|
 Worm   274 DFQWEVLAGHLAL-YGVDGIFRVFVHSSFDDSDKNVLMFSPPKLFLEKKKFYREVPSSNVYLQYY 337

  Fly   231 RNNIQRILQRYLGVKMD----LAKKTAKELIDFEVDLAQGLVDESEGLDVGELTQLLTVDEIQRR 291
            |..|..:|. .|||.|:    :.:....::||||..:| .|.......:...:..::|..|.:|:
 Worm   338 RQYILSLLS-LLGVDMEDETGVIEYQVDDIIDFERRIA-NLTRIELSRNHSSINNMITFGEFKRK 400

  Fly   292 YSPTLDIDRLLFVS------------MGERISDQIYEYNNRYQQNLVEVIKRTPKRTVANYIFFR 344
            |      |::.:.:            |.:.:...:.:.|  |..||..:||..|..::.|::.:.
 Worm   401 Y------DKINWDAFFNEEMRGNLGRMPDSLVINVVDVN--YFDNLYSLIKSKPLSSINNFLMWC 457

  Fly   345 LIWEF-------------------VETPSDSPEKQMKACVDLTKKYFAKNLDNMFYRRYNNEKSS 390
            |:..:                   ....||.|  ..:.||...::..|..|...:.:::..:|..
 Worm   458 LVSNYDMYLPAKYRKPMLDFRQKMYGVSSDDP--LWEVCVGEVRENLAMPLSTEYAQKFFTKKDK 520

  Fly   391 REIDNMWRQLKSTFNETLRSSPALNWIERPTRNLAMAKLQAMTLEVNNYADDNFTE-----EFAE 450
            ...::|.|.||....:||.::   :||:..||..|:.||.||..:: .:.|....|     .:|.
 Worm   521 LVAEDMIRDLKKAMEQTLLNA---DWIDESTREAALMKLDAMGHKI-GFPDSLLNETAVLLPYAG 581

  Fly   451 LNLQSDDYVENVRYTSLLGAKQMREMLHKP------AKPFEAGSQLSYTPANILIENTIKVPVAL 509
            :.|.::.|.:|.........:.....||:.      |.|..|.....|...|.:|     .|..:
 Worm   582 VRLTANQYFDNAISLKKAAYRDALSKLHRTPSLIDWASPIIAVDAFHYFTGNEII-----FPAGI 641

  Fly   510 LQ-PFYIWSDVYPNAIMF---GTLASLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRR 570
            || |.::     |:|..|   |.:...||||:.||:||.|.::|:|||.:.||..::.:.|.|::
 Worm   642 LQFPMFV-----PDAPAFSNYGAIGMGIGHEITHGYDDLGAQYDDKGNLRGWWHTETMTTFQKKK 701

  Fly   571 DCFTKQYGRYV--YDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKET-- 631
            .||..|||..:  ..|.::.......||||||||:|:|:.||      ||     ..|..|||
 Worm   702 QCFVAQYGSKIEPQTGRKVDGKMTIGENIADNGGLRVAFQAY------QL-----RSDREKETRR 755

  Fly   632 LPNLR-YTAKQLFFISFAQSWCNDAHPSVKALQVSTDQHMPGRFRVIGSLSNFEEFSKEFNCPAG 695
            ||.|. ::..||||:::|.:||....||.....:.||.|..|.|||...|.|...|||||:||.|
 Worm   756 LPGLTDFSPNQLFFLAYANTWCEALKPSAIDHIMDTDVHSLGMFRVNVPLQNLPAFSKEFDCPIG 820

  Fly   696 SAMNPSEKCILY 707
            |.|||.|||.::
 Worm   821 SPMNPFEKCRIW 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	M13	63..704	CDD:341056	191/699 (27%)
nep-12	NP_001364537.1	M13	171..830	CDD:341056	192/700 (27%)