DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl21 and Mme

DIOPT Version :9

Sequence 1:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_001276391.1	Gene:	Mme / 17380	MGIID:	97004	Length:	750	Species:	Mus musculus

Alignment Length:	750	Identity:	190/750 - (25%)
Similarity:	338/750 - (45%)	Gaps:	117/750 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 MVAAAPTSEEDLKQDTPYMKELLRQAKTAEIESFMDQKADPCNDFYAFSCGNYKRINSALSMQVV 89
            |:|...|.::.:.:.:..:|...|..:.      ||...:||.||:.::||.:.:.|.
Mouse    45 MIALYATYDDGICKSSDCIKSAARLIQN------MDASVEPCTDFFKYACGGWLKRNV------- 96

  Fly    90 TTGVFETLTKGLNRKILK---------MLNTPHDSHDTPEDI----KVKHFYESCLQIKELNSTY 141
               :.||.::..|..||:         :|..|     ..|||    |.|..|.||:....::|..
Mouse    97 ---IPETSSRYSNFDILRDELEVILKDVLQEP-----KTEDIVAVQKAKTLYRSCINESAIDSRG 153

  Fly   142 SEKLKRLIAEFGTMPLLE-------GSSWQEDDFDWLNTTARMAYRYGITPIFGIEVNKDLASNT 199
            .:.|.:|:.:....|:..       |:||..:     .:.|::..:||...:....|..|..::|
Mouse   154 GQPLLKLLPDIYGWPVASDNWDQTYGTSWTAE-----KSIAQLNSKYGKKVLINFFVGTDDKNST 213

  Fly   200 RNRIYLGQQDFPLEARSMYVDDATAVYRQ------KYRNNIQRILQRYLGVKMDLAKKTAK--EL 256
            ::.|:..|....|.:|..|  :.|.:|::      .:..::.|::::...:.:|..:.:.:  ::
Mouse   214 QHIIHFDQPRLGLPSRDYY--ECTGIYKEACTAYVDFMISVARLIRQEQSLPIDENQLSLEMNKV 276

  Fly   257 IDFEVDLAQGLVDESEGLDVGELTQLLTVDEIQRRYSPTLDIDRLLF------------VSMGER 309
            ::.|.::|.......:..|...|...:|:.::|..:|  |:::...|            |::..:
Mouse   277 MELEKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFS--LEVNGKSFSWSNFTNEIMSTVNINIQ 339

  Fly   310 ISDQIYEYNNRYQQNLVEVIKRTPKRTVANYIFFRLIWEFVETPS----DSPEKQMKACVDLTKK 370
            ..:::..|...|...|..::.:...|.:.|.:.:|.|.:.|.:.|    :|.....||....|.:
Mouse   340 NEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSE 404

  Fly   371 ---------YFAKNLDNMFYRRYNNE----KSSREIDNMWRQLKSTFNETLRSSPALNWIERPTR 422
                     |...|::|...|.|...    :|...::::..|::..|.:||..   |.|::..|:
Mouse   405 TATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDD---LTWMDAETK 466

  Fly   423 NLAMAKLQAMTLEVNNYADD------NFTEEFAELNLQSDDYVENV----RYTSLLGAKQMREML 477
            ..|..|..|:...: .|.||      ....|:.|||.:.|:|.||:    :::.....|::||.:
Mouse   467 KKAEEKALAIKERI-GYPDDIISNENKLNNEYLELNYREDEYFENIIQNLKFSQSKQLKKLREKV 530

  Fly   478 HKPAKPFEAGSQLSYTPANILIENTIKVPVALLQPFYIWSDVYPNAIMFGTLASLIGHELIHGFD 542
            .|......|....::..:.   .|.|..|..:|||.: :|....|::.:|.:..:||||:.||||
Mouse   531 DKDEWISGAAVVNAFYSSG---RNQIVFPAGILQPPF-FSAQQSNSLNYGGIGMVIGHEITHGFD 591

  Fly   543 DSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYD---GIQLKESTAQSENIADNGGMR 604
            |:||.|::.|:..|||.::|::||..:..|...|||.:.:|   |..|.......||||||||:.
Mouse   592 DNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGIG 656

  Fly   605 LAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDAHPSVKALQVSTDQH 669
            .||.||:.:.:.     ||.:.:    ||.|....|||||::|||.||....|......:.||.|
Mouse   657 QAYRAYQNYVKK-----NGEEKL----LPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVH 712

  Fly   670 MPGRFRVIGSLSNFEEFSKEFNCPAGSAMNPSEKC 704
            .||.||:||:|.|..||:..|:|...|.|||..||
Mouse   713 SPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKC 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	184/717 (26%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	181/710 (25%)
Mme	NP_001276391.1	Stop-transfer sequence. /evidence=ECO:0000255	16..23
Mme	NP_001276391.1	M13	77..748	CDD:341056	182/711 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841049
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950