DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl21 and Ecel1

DIOPT Version :9

Sequence 1:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_001264854.1	Gene:	Ecel1 / 13599	MGIID:	1343461	Length:	775	Species:	Mus musculus

Alignment Length:	762	Identity:	212/762 - (27%)
Similarity:	355/762 - (46%)	Gaps:	136/762 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VLSAMVA-------------AAPTSEEDLKQDTPYMKELLRQAKTAEIESFMDQKADPCNDFYAF 72
            :|:||:|             |.|       :..|..|...|.|:.  :.:.:|...|||.|||:|
Mouse    75 ILAAMLALKYLGPGAAGGGGACP-------EGCPERKAFARAARF--LSANLDASIDPCQDFYSF 130

  Fly    73 SCGNYKRINSALSMQVVTTGVFETLTKGLNRKILKMLNTPHDSHDTPEDIKVKHFYESCLQIKEL 137
            :||.:.| ..|:....:|.|....:.:....::.::|..|..........||:.|:.|||.::|:
Mouse   131 ACGGWLR-RHAIPDDKLTYGTIAAIGEQNEERLRRLLARPTGGPGGAAQRKVRAFFRSCLDMREI 194

  Fly   138 NSTYSEKLKRLIAEFGTMPLLE-----------GSSWQEDDFDW-LNTTARMAYR----YGITPI 186
                 |:|       |..|:||           |::.:.....| ||   |:.|:    |....:
Mouse   195 -----ERL-------GPRPMLEVIEDCGGWDLGGAADRPGAARWDLN---RLLYKAQGVYSAAAL 244

  Fly   187 FGIEVNKDLASNTRNRIYLGQQDFPLEARSMYV--DDATAVYRQKYRNNIQRILQRYLGVKMDLA 249
            |.:.|:.|..:::|..|.:.|....|..|::|:  |:.:......||..:||:| |.||.  |..
Mouse   245 FSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEESEKILAAYRVFMQRLL-RLLGA--DAV 306

  Fly   250 KKTAKELIDFEVDLAQGLVDESEGL--DVGELTQLLTVDEIQRRYSPTLDIDRLLFVSMGERISD 312
            ::.|:|::..|..||...|.|.:.|  ||......:|:.::| :..|.|....||         |
Mouse   307 EQKAQEILQLEQRLANISVSEYDDLRRDVSSAYNKVTLGQLQ-KIIPHLQWKWLL---------D 361

  Fly   313 QIYEYN-----------NRYQQNLVEVIKRTPKRTVANYIFFRLI---WEFVETP---------- 353
            ||::.:           ..|.|.:.::|:.||:|.:.||:.:|::   .|.:.:|
Mouse   362 QIFQEDFSEEEEVVLLATDYMQQVSQLIRSTPRRILHNYLVWRVVVVLSEHLSSPFREALHELAK 426

  Fly   354 ----SDSPEKQMKACVDLTKKYFAKNLDNMFYRRYNNEKSSREIDNMWRQLKSTFNETLRSSPAL 414
                :|.|::..:.|:....::|...|..:|...:.:..|..::..:...:|....:.|..   |
Mouse   427 EMEGNDKPQELARVCLGQANRHFGMALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEE---L 488

  Fly   415 NWIERPTRNLAMAKLQAMTLEVNNYAD-----DNFTEEFAELNLQSDDYVEN----VRYTSLLGA 470
            :|::..|:..|.||||.|.:.| .|.|     :...:|: |..:....|.:|    :|::..|..
Mouse   489 DWMDAQTKAAARAKLQYMMVMV-GYPDFLLKPEAVDKEY-EFEVHEKTYFKNILNSIRFSIQLSV 551

  Fly   471 KQMREMLHK-----PAKPFEAGSQLSYTPANILIENTIKVPVALLQPFYIWSDVYPNAIMFGTLA 530
            |::|:.:.|     |.:...|    .|.|.    :|.:..|..:||| .::...:|.::.:|.:.
Mouse   552 KKIRQEVDKSSWLLPPQALNA----YYLPN----KNQMVFPAGILQP-TLYDPDFPQSLNYGGIG 607

  Fly   531 SLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYDGIQLKESTAQSE 595
            ::|||||.||:||.|.::|..||...||.|.|.|:||::.:|..:.|..:.....::.......|
Mouse   608 TIIGHELTHGYDDWGGQYDRSGNLLHWWTETSYSHFLRKAECIVRLYDNFTVYNQRVNGKHTLGE 672

  Fly   596 NIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDAHPSVK 660
            ||||.||::|||.||:||...     :|.:    ..|..|:||..|||||:|||:||........
Mouse   673 NIADMGGLKLAYYAYQKWVRE-----HGPE----HPLHRLKYTHNQLFFIAFAQNWCIKRRSQSI 728

  Fly   661 ALQVSTDQHMPGRFRVIGSLSNFEEFSKEFNCPAGSAMNPSEKCILY 707
            .|||.||:|.|..:||:||:|.||||.:.|:||..|.|||..||.::
Mouse   729 YLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPVHKCSVW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	202/711 (28%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	199/702 (28%)
Ecel1	NP_001264854.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..52
Ecel1	NP_001264854.1	M13	121..773	CDD:341056	200/703 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841100
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940