DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl21 and Gm49333

DIOPT Version :9

Sequence 1:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_808810.1	Gene:	Gm49333 / 110599584	MGIID:	6121518	Length:	910	Species:	Mus musculus

Alignment Length:	753	Identity:	216/753 - (28%)
Similarity:	344/753 - (45%)	Gaps:	119/753 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LCICIAGHVLSAMVAAAPTSEEDLKQDTPYMKELLRQAKTAEIESFMDQKADPCNDFYAFSCGNY 77
            |.:.:|..:|..:||.  ....|....|...:..:|.|  .:|...:|:...||.|||.||||.:
Mouse   213 LILVLAALLLGCLVAL--WVHRDPAHSTCVTEACIRVA--GKILESLDRGVSPCQDFYQFSCGGW 273

  Fly    78 KRINSALSMQVVTTG-----VFETLTKGLNRKILKML--NTPHDSHDTPEDIKVKHFYESCLQIK 135
            .|.|.      :..|     .|.:|. ..|:.|||.|  ||..:|....|. |.:.||.||||.:
Mouse   274 IRRNP------LPNGRSRWNTFNSLW-DQNQAILKHLLENTTFNSSSEAER-KTRSFYLSCLQSE 330

  Fly   136 ELNSTYSEKLKRLIAEFG----TMPLLEGSSWQEDDFDWLNTTARMAYRYGITPIFGIEVNKDLA 196
            .:....::.|:.||.:.|    |.|      |.||.|  ::....:|..|..||.|.:.|:.|..
Mouse   331 RIEKLGAKPLRDLIDKIGGWNITGP------WDEDSF--MDVLKAVAGTYRATPFFTVYVSADSK 387

  Fly   197 SNTRNRIYLGQQDFPLEARSMYVDDATAVYRQKYRNNIQRILQRYLGVKMDL----------AKK 251
            |:..|.|.:.|....|.:|..|::          |...:::|..||...::|          .::
Mouse   388 SSNSNIIQVDQSGLFLPSRDYYLN----------RTANEKVLTAYLDYMVELGVLLGGQPTSTRE 442

  Fly   252 TAKELIDFEVDLAQGLVDESEGLDVGELTQLLTVDEIQRRYSPTLD-IDRLLF----VSMGERIS 311
            ..:::::.|:.||...|.:.:..|..::...:::.|:| ..:|.:| ::.|.|    :.:|:  |
Mouse   443 QMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQ-ALAPAVDWLEFLSFLLSPLELGD--S 504

  Fly   312 DQIYEYNNRYQQNLVEVIKRTPKRTVANYIFFRLIWEFVETPSDSPEKQM--------------- 361
            :.:..|...|.|.:.|:|.||....:.||    |||..|:..:.|.:::.
Mouse   505 EPVVVYGTEYLQQVSELINRTEPSILNNY----LIWNLVQKTTSSLDQRFETAQEKLLETLYGTK 565

  Fly   362 -------KACVDLTKKYFAKNLDNMFYRRYNNEKSSREIDNMWRQLKSTFNETLRSSPALNWIER 419
                   :.|:..|.......|.::|.:...:.:|....:.|..:::|.|.|||..   |.|::.
Mouse   566 KSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMINEIRSAFEETLGD---LVWMDE 627

  Fly   420 PTRNLAMAKLQAMTLEVNNYADDNFTEEFAELN-------LQSDDYVENVRYTSLLGAKQMREML 477
            .||..|..|..|: .::..:.|  |..|..||:       :..|.:.:|:.......||.|.:.|
Mouse   628 KTRLAAKEKADAI-YDMIGFPD--FILEPKELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQL 689

  Fly   478 HKPAKPFEAGSQLSYTPANI-----LIENTIKVPVALLQ-PFYIWSDVYPNAIMFGTLASLIGHE 536
            .||    .:..|.|.||..:     ..:|.|..|..:|| |||..:  :|.|:.||.:..::|||
Mouse   690 RKP----PSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHN--HPKALNFGGIGVVMGHE 748

  Fly   537 LIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYDGIQLKESTAQSENIADNG 601
            |.|.|||.||::|::||.:.||..:|.:.|.....|..:||.:|..:|.:|.......|||||||
Mouse   749 LTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQYQVNGERLNGLQTLGENIADNG 813

  Fly   602 GMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDAHPSVKALQVST 666
            |::.||.||:.|...     :|.:    :.||.:..|..||||:.|||.||:...|......:.|
Mouse   814 GLKAAYNAYKAWLRK-----HGEE----QPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVT 869

  Fly   667 DQHMPGRFRVIGSLSNFEEFSKEFNCPAGSAMNPSEKC 704
            |.|.|.||||:|:|||..:|.:.|.||.||.|||.:.|
Mouse   870 DPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLC 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	206/709 (29%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	204/701 (29%)
Gm49333	NP_808810.1	AdoMet_MTases	63..>128	CDD:302624
		PepO	248..901	CDD:226118	204/708 (29%)
		M13	259..908	CDD:189000	205/703 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841082
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950