DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl21 and EEF1AKMT4-ECE2

DIOPT Version :9

Sequence 1:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_055508.3	Gene:	EEF1AKMT4-ECE2 / 110599583	HGNCID:	53615	Length:	883	Species:	Homo sapiens

Alignment Length:	749	Identity:	211/749 - (28%)
Similarity:	342/749 - (45%)	Gaps:	113/749 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ICIAGHVLSAMVAAAPTSEEDLKQDTPYMKELLRQAKTAEIESFMDQKADPCNDFYAFSCGNYKR 79
            :.:|..:|..:||.......|....|...:..:|.|  .:|...:|:...||.|||.||||.:.|
Human   186 LLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVA--GKILESLDRGVSPCEDFYQFSCGGWIR 248

  Fly    80 INSALSMQVVTTG-----VFETLTKGLNRKILKML--NTPHDSHDTPEDIKVKHFYESCLQIKEL 137
            .|.      :..|     .|.:|. ..|:.|||.|  ||..:|....|. |.:.||.||||::.:
Human   249 RNP------LPDGRSRWNTFNSLW-DQNQAILKHLLENTTFNSSSEAEQ-KTQRFYLSCLQVERI 305

  Fly   138 NSTYSEKLKRLIAEFG----TMPLLEGSSWQEDDFDWLNTTARMAYRYGITPIFGIEVNKDLASN 198
            ....::.|:.||.:.|    |.|      |.:|:|  :.....:|..|..||.|.:.::.|..|:
Human   306 EELGAQPLRDLIEKIGGWNITGP------WDQDNF--MEVLKAVAGTYRATPFFTVYISADSKSS 362

  Fly   199 TRNRIYLGQQDFPLEARSMYVDDATAVYRQKYRNNIQRILQRYLGVKMDL----------AKKTA 253
            ..|.|.:.|....|.:|..|::          |...:::|..||....:|          .::..
Human   363 NSNVIQVDQSGLFLPSRDYYLN----------RTANEKVLTAYLDYMEELGMLLGGRPTSTREQM 417

  Fly   254 KELIDFEVDLAQGLVDESEGLDVGELTQLLTVDEIQRRYSPTLD-IDRLLFVSMGERISDQ--IY 315
            :::::.|:.||...|.:.:..|..::...:::.|:| ..:|::| ::.|.|:.....:||.  :.
Human   418 QQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQ-ALAPSMDWLEFLSFLLSPLELSDSEPVV 481

  Fly   316 EYNNRYQQNLVEVIKRTPKRTVANYIFFRLIWEFVETPSDSPEKQMKA----------------- 363
            .|...|.|.:.|:|.||....:.||    |||..|:..:.|.:::.::
Human   482 VYGMDYLQQVSELINRTEPSILNNY----LIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCV 542

  Fly   364 -----CVDLTKKYFAKNLDNMFYRRYNNEKSSREIDNMWRQLKSTFNETLRSSPALNWIERPTRN 423
                 |:..|.......|.::|.:...:.:|....:.|..::::.|.|.|..   |.|::..||.
Human   543 PRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQ---LVWMDEKTRQ 604

  Fly   424 LAMAKLQAMTLEVNNYADDNFTEEFAELN-------LQSDDYVENVRYTSLLGAKQMREMLHKPA 481
            .|..|..|: .::..:.|  |..|..||:       :..|.:.:|:.......||.|.:.|.||
Human   605 AAKEKADAI-YDMIGFPD--FILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKP- 665

  Fly   482 KPFEAGSQLSYTPANI-----LIENTIKVPVALLQ-PFYIWSDVYPNAIMFGTLASLIGHELIHG 540
               .:..|.|.||..:     ..:|.|..|..:|| |||..:  :|.|:.||.:..::||||.|.
Human   666 ---PSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARN--HPKALNFGGIGVVMGHELTHA 725

  Fly   541 FDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYDGIQLKESTAQSENIADNGGMRL 605
            |||.||::|::||.:.||..:|.:.|.....|..:||.:|..:|.:|.......||||||||::.
Human   726 FDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKA 790

  Fly   606 AYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDAHPSVKALQVSTDQHM 670
            ||.||:.|...     :|.:    :.||.:..|..||||:.|||.||:...|......:.||.|.
Human   791 AYNAYKAWLRK-----HGEE----QQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHS 846

  Fly   671 PGRFRVIGSLSNFEEFSKEFNCPAGSAMNPSEKC 704
            |.||||:|:|||..:|.:.|.||.||.|||.:.|
Human   847 PARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLC 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	202/707 (29%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	200/699 (29%)
EEF1AKMT4-ECE2	NP_055508.3	Methyltransferase-like region. /evidence=ECO:0000305	1..160
		Methyltransf_25	62..>128	CDD:316196
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:P0DPD7	88..89
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:P0DPD7	113..114
		M13	232..881	CDD:189000	201/701 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150966
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950