DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl21 and kel

DIOPT Version :9

Sequence 1:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	XP_005157998.1	Gene:	kel / 101882278	ZFINID:	ZDB-GENE-110411-118	Length:	759	Species:	Danio rerio

Alignment Length:	749	Identity:	155/749 - (20%)
Similarity:	269/749 - (35%)	Gaps:	188/749 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 MDQKADPCNDFYAFSCG--------NYKRINSALS--MQVVTTGVFETL--TKGLNRK------- 104
            ||..:.|| |::.|:||        :.:|:...::  .:|.|.|:.|..  |.|.::.
Zfish    94 MDPFSRPC-DYFLFACGAGGSSTNRDRQRVKGEVNKHSEVRTRGLIEMRRGTDGWSKSDGQLKTF 157

  Fly   105 ----------ILKMLNTPHD--SHDTPEDIKVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPL 157
                      |.::|..|.:  |....|. |.|:|::||:..:......||....|:.:.|...:
Zfish   158 PDRQTALLTAIKEILEAPDEAVSMGAAEQ-KAKNFFKSCMNAESREKMGSEPFLTLLQQLGGWAV 221

  Fly   158 LEGSSWQEDDFDWLNTTARMAYRYGITPIF----GIEVNKDLASNTRNRIYLGQQ--DFPLEARS 216
              ...|.:.||:  :|.|.:..:|...|.|    |.|.:::.:::.|:.|.:.:.  .||:|..|
Zfish   222 --SGVWNQTDFN--STLALLMGQYSTFPFFNVYVGPEPSEEQSASNRHYIQIDEPHFQFPIEWNS 282

  Fly   217 MYVDDATAVYRQKYRNNIQRILQRY---------LGVKMDLAKKTAKELIDFEVDLAQGLVDESE 272
            .         .||.:.|.:.:...|         |||..|...:.....:.....||........
Zfish   283 K---------TQKAKANTRYLRPFYSACGQYLVLLGVPSDRTTQHCGLFVSLSTTLAVATFPLPY 338

  Fly   273 GLDVGELTQLLTVDEIQRRYSPTLD-------IDRLLFVSMGERISDQIYEYNNRY--------- 321
            .|....|.:..|:.|:| ..:|.:|       ..:.|.:|.    ||.:..:|..|
Zfish   339 RLSQKLLYRRTTIQELQ-TLAPAVDWLACLQATFQPLLISK----SDIVLVHNLPYIIHMSKTIH 398

  Fly   322 -QQNLVEVIKRTPKRTVANYI------------FFRLIWEFVETPSDSPE-KQMKACVDLTKKYF 372
             .|...|::...|..|...:.            ||:::..:.....|:.| .....||..|::.|
Zfish   399 LWQVQHELMGTGPLNTYMIFSLLQTLIPALDSRFFQIMRNYSIATGDTQEMPHWWRCVQQTERGF 463

  Fly   373 AKNLDNMFYRRYNNEKSSREIDNMWRQLKSTFNETLRSSPALNWIERPTRNLAMAKLQAM----T 433
            ...|.:....::..:::...|.:::..||....:       |:|.:....:..:.|:.::    :
Zfish   464 DTLLSHAIREKHAQKEAEELIQDVYSSLKKKLTD-------LSWRDEKESDFILNKINSLNPRIS 521

  Fly   434 LEVNNYADDNFTEEFAELNLQSDDYVENVRYTSLLGAKQMREMLHKPAKPFEAGSQ---LSYTPA 495
            ...||.:.......:.::.|..:|:..|.....||..|....:|       ..|:|   ||.||
Zfish   522 TNTNNLSYTELNHLYEKVILNEEDFFSNYLQILLLEQKSRARLL-------SLGTQTEGLSMTP- 578

  Fly   496 NILIENTIKVPVAL-LQPFYIWSDVYPNAIMFGTLASLIGHELIHGFDDSGRKFDEKGNSKDWWD 559
             .:..|.|.|||.: :.||:..|  ||.|:.:|||.||:..:|:|
Zfish   579 -FISGNDIIVPVGMFVSPFFHSS--YPRALNYGTLGSLMAKDLLH-------------------- 620

  Fly   560 EKSSSNFLKRRDCFTKQ----------YGRYVY--------DGIQLKESTAQSENIADNGGMRLA 606
                   |...|.:||.          :..|:.        |...| .|:.|.|.......:::|
Zfish   621 -------LLLPDIYTKAKNPETESLCVWSHYLSVTKGPGWGDAFYL-PSSKQQEVWVQYSALQVA 677

  Fly   607 YTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCN-DAHPSVKALQVSTDQHM 670
            ..||:..::..|         ...:||...|.  .||..||.:..|: ||:.....|:.|
Zfish   678 LDAYKMSFKRYL---------ADSSLPGFSYV--HLFLSSFTKVTCDTDAYREFMPLEPS----- 726

  Fly   671 PGRFRVIGSLSNFEEFSKEFNCPAGSAMNPSEKC 704
               |.|....||.....|...|.......|:|.|
Zfish   727 ---FLVTVLCSNSGLCPKPLTCMNKPQSFPAEMC 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	155/749 (21%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	152/743 (20%)
kel	XP_005157998.1	GluZincin	99..>620	CDD:301352	117/558 (21%)
kel	XP_005157998.1	GluZincin	583..>721	CDD:301352	42/178 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585559
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950