DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl21 and mme

DIOPT Version :9

Sequence 1:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	XP_031758820.1	Gene:	mme / 101734885	XenbaseID:	XB-GENE-1011098	Length:	746	Species:	Xenopus tropicalis

Alignment Length:	775	Identity:	202/775 - (26%)
Similarity:	337/775 - (43%)	Gaps:	127/775 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KQLLCICI-AGHVLSAMVAAAPTSEEDLKQDTPYMKELLRQAKTAEIESFMDQKADPCNDFYAFS 73
            |.|:.:|| .|.:..||:.|..||.:.:......:      :..|.|.:.||...|||||||.::
Frog    22 KGLIILCIFLGIISIAMILAYATSNDGICTSQACI------STAARIIANMDAATDPCNDFYQYA 80

  Fly    74 CGNYKRINSALSMQVVTTGVFETLTKGLNRKILKMLNTPHDSHDTPEDIKVKHFYESCLQ--IKE 136
            ||.:.:.|......:| :..|:.|...: ..:||.......:.|.|...|||.||:||:.  ||.
Frog    81 CGGWLKKNRIPDNNIV-SNTFDILRTDI-EVVLKDALEKESADDIPAIKKVKTFYKSCIDETIKN 143

  Fly   137 LNSTYSEKLKRLIAEFGTMPLLEGSSWQEDDFDW-----------------LNTTARMAYRYGIT 184
            |     .|...||.   |:|.|         :||                 ..:.|....:||.:
Frog   144 L-----RKGGPLIK---TLPAL---------YDWPIAVDNWETRYGLVWSAQESIAGFITKYGQS 191

  Fly   185 PIFGIEVNKDLASNTRNRIYLGQQDFPLEARSMY-----VDDATAVYRQKYRNNIQRI-LQRYLG 243
            .:..:.|::||.:::...:::.|....|.::..|     .:.|...|.::..:....| .:|.|.
Frog   192 GLINVYVSEDLTNSSTYILHIDQPGLGLPSKDYYDCKGTSEIACLAYMEQMVSVAMLIRKERNLT 256

  Fly   244 VKMDLAKKTAKELIDFEVDLAQGLVDESEGLDVGELTQLLTVDEIQRRYSPTLDIDRLLFVSMGE 308
            :..|......:::...|.::|:....|....::.::.:.:|:..|.:.|...::...:.::.:..
Frog   257 INEDKILSEMEKVFKLEREIAKAEASEEIRENLNDIYKKMTLSGIAKTYPLKMNDQNINWLKLIN 321

  Fly   309 RI----------SDQIYEYNNRYQQNLVEVIKRTPKRTVANYIFFRLIWEFVETPS--------- 354
            .|          ::|:....:.|.:.| ..:.:...|.:.||:.:|.|...:...|
Frog   322 AIISPGGVSIEENEQVALICSDYLKKL-RFLNKYKARELQNYLGWRYILSAINDLSLEYKNTGIH 385

  Fly   355 -------DSPE-KQMKACVDLTKKYFAKNLDNMFYRRYNNEKSSREIDN---------MWRQLKS 402
                   ::.| ...:.||    .|...|:::...|.|..|..|.:|::         :..:::.
Frog   386 LKKALYGNAAEGSDWQTCV----TYLNDNMEDAIGRLYLKETLSADIEHVKVKDKVKEIIAEIRR 446

  Fly   403 TFNETLRSSPALNWIERPTRNLAMAKLQAMTLEV---NNYADD-NFTEEFAELNLQSDDYVENVR 463
            .|.|.|..   ::|::..|:..|..|:.::...:   .:..|| ...|.::||..:.|:..||.:
Frog   447 AFLEMLEE---MDWMDEDTKKRAARKVASINERIAFSEDIMDDFKLNEGYSELEFRVDELFENKQ 508

  Fly   464 YTSLLGAKQMREMLHKPAKPFE--AGSQLSYTPANI-----LIENTIKVPVALLQ-PFYIWSDVY 520
            .......|:|...|.|.....|  .|      ||::     |..|.|..|..:|| ||:  |...
Frog   509 KYIEFVQKKMTSRLRKQVNKNEWVPG------PAHVNAFYSLTYNEIVFPAGILQTPFF--SSSQ 565

  Fly   521 PNAIMFGTLASLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYD-- 583
            |:|:.:|.:..:||||:.||||:.|..|||.||..:||...|..||.....||..|||.|.:|
Frog   566 PSALNYGGIGMIIGHEITHGFDNRGCNFDEHGNLVNWWTNASMMNFSNLSQCFVNQYGNYSWDEA 630

  Fly   584 -GIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISF 647
             |..|...:...|||:||||:|.||.|::.:.::.      .:|   :.||.:...:.|||||||
Frog   631 GGQYLNGISTLGENISDNGGIRGAYRAFKNYVKSH------KED---DLLPGIDLDSDQLFFISF 686

  Fly   648 AQSWCNDAHPSVKALQVSTDQHMPGRFRVIGSLSNFEEFSKEFNCPAGSAMNPSEKCILY 707
            .|.||....|...|..:.|..|.||.|||||:|.|..||||.|:|...:.|||:.||.|:
Frog   687 GQIWCGMHRPEYAATLIKTGSHTPGIFRVIGTLQNSPEFSKAFSCCNNAYMNPAVKCKLW 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	189/725 (26%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	185/716 (26%)
mme	XP_031758820.1	M13	71..744	CDD:341056	186/716 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020