DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl21 and ece1

DIOPT Version :9

Sequence 1:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	XP_031762312.1	Gene:	ece1 / 100485607	XenbaseID:	XB-GENE-1014218	Length:	782	Species:	Xenopus tropicalis

Alignment Length:	716	Identity:	214/716 - (29%)
Similarity:	330/716 - (46%)	Gaps:	119/716 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 TAEIESFMDQKADPCNDFYAFSCGNYKRINSALSMQVVTTGVFETLTKGLNRKILKML--NTPHD 114
            |:.|...:|:.||||.|||.:|||.:.:.|...... ...|.|..|.:. |:..:|.|  |:..:
Frog   120 TSSILRSLDRSADPCQDFYQYSCGGWIKGNPVPDGH-SRWGTFNELWEH-NQATMKHLLENSTIE 182

  Fly   115 SHDTPEDIKVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQEDDFDWLNTTARMAY 179
            ::.|.|. |.:.::::|:...::....::.|:.||.:.|...:.  ..|..|:|.  .|...:..
Frog   183 TNSTAER-KAQRYFQACMNETKIEELGAKPLQDLIQKLGGWAIT--GPWDRDNFQ--ETLQLVTA 242

  Fly   180 RYGITPIFGIEVNKDLASNTRNRIYLGQQDFPLEARSMYVDDATAVYRQKYRNNIQRILQRYLGV 244
            .|..:|.|.:.|:.|..::..|.|.:.|....|.:|..|::        |..|  :::|..||..
Frog   243 HYRTSPFFSVFVSADSKNSNSNVIQIDQSGLGLPSREFYLN--------KTEN--EKVLTGYLNF 297

  Fly   245 KMDL----------AKKTAKELIDFEVDLAQGLVDESEGLD---------VGELTQLL-TVDEIQ 289
            .:.|          .::..:|::|||..||...:.:.:..|         .|||..|: .||
Frog   298 MIQLGVLLGGAENSTREQMQEILDFETTLANITIPQEKRRDEEQIYHKMAAGELKDLVPAVD--- 359

  Fly   290 RRYSPTLDIDRLLFVSMGERISDQIYEYNNRYQQNLVEVIKRTPKRTVANYIFFRLIWEFVETPS 354
              :.|.|   :.:|..:....|:.:..|...|...:..:|..|.||.:.||    ::|..|...|
Frog   360 --WMPFL---QTVFYPVAINESEPVVVYAKEYLVAVSGLINSTDKRILNNY----MMWNLVRKAS 415

  Fly   355 --------DSPEKQM--------------KACVDLTKKYFAKNLDNMFYRRYNNEKSSREIDNMW 397
                    |:.||.|              |.|:..|.......|..||.:....|.|..:...|.
Frog   416 SFLDQRFQDAEEKLMEVMYGTKKTCLPRWKFCISDTDNNLGFALGAMFVKATFAENSKLQALKMI 480

  Fly   398 RQLKSTFNETLRSSPALNWIERPTRNLAMAKLQAM--TLEVNNYADD--NFTEEFAELNLQSDDY 458
            :::|:.|.|.|.:   |.|::..||..|..|.:|:  .:...|:..|  ...:.|.:.|:.||.|
Frog   481 KEIKAAFEENLST---LTWMDDETRRAAREKAEAIYDMIGYPNFIMDPKELDKVFNDYNVTSDFY 542

  Fly   459 VEN----VRYTSLLGAKQMREMLHKPAKPFEAGSQLSYTPANI-----LIENTIKVPVALLQ-PF 513
            .||    ..:::.:.|.|:|:   .|:|     .|.|.||..:     ..:|.|..|..:|| ||
Frog   543 FENGMRFYNFSARVTADQLRK---APSK-----DQWSMTPPTVNAYYSPTKNEIVFPAGILQAPF 599

  Fly   514 YIWSDVYPNAIMFGTLASLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYG 578
            |..|.  |.|:.||.:..::||||.|.|||.||::|:.||.:.||...|...|.|:.:|.|:|||
Frog   600 YTSSS--PTALNFGGIGVVMGHELTHAFDDQGREYDKDGNLRPWWKNASVEAFKKQTECITEQYG 662

  Fly   579 RYVYDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLF 643
            .|..:|..:.......||||||||::.||.||:.|...     |||:.:    ||:|..:..|||
Frog   663 NYTVNGEPVNGRQTLGENIADNGGLKAAYRAYKNWVRK-----NGAEQL----LPSLGLSNDQLF 718

  Fly   644 FISFAQSWCNDAHPSVKALQVS-----TDQHMPGRFRVIGSLSNFEEFSKEFNCPAGSAMNPSEK 703
            |:.|||.||     ||:..:.|     ||.|.|.|||||||:||.:||::.|.||.||.|||..|
Frog   719 FVGFAQVWC-----SVRTSESSHEGLITDPHSPSRFRVIGSVSNSQEFAEHFRCPPGSPMNPRNK 778

  Fly   704 C 704
            |
Frog   779 C 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	212/711 (30%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	209/703 (30%)
ece1	XP_031762312.1	M13	131..780	CDD:341056	211/705 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010