Protein Alignment Nepl21 and mmel1

DIOPT Version :10

• Sequence 1: NP_651646.2
• Gene: Nepl21 / 43413
• FlyBaseID: FBgn0027578
• Length: 707
• Species: Drosophila melanogaster
• Sequence 2: XP_012821551.1
• Gene: mmel1 / 100145721
• XenbaseID: XB-GENE-991673
• Length: 765
• Species: Xenopus tropicalis
• Alignment Length: 727
• Identity: 206/727 - (28%)
• Similarity: 321/727 - (44%)
• Gaps: 124/727 - (17%)

  Fly    53 AEIESFMDQKADPCNDFYAFSCGNY--KRI----NSALSMQVVTTGVFETLTKGLNRKILKMLNT 111
            |.|...||...:||.|||.::||.:  |.:    :|..|:..:.....|.:.|||       |..
 Frog    85 ARIIQNMDPTIEPCTDFYQYACGGWLNKHVIPETSSRYSIFDILRDEMEIILKGL-------LEM 142

  Fly   112 PHDSHDTPEDIKVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLE----GSSWQEDDFDWLN 172
            | |..|.....|.|..|:||:.            :.||.:..::||||    ...|.....||..
 Frog   143 P-DQEDRDAFKKAKILYKSCMN------------ESLIEQRDSLPLLELLTTVGEWPVASTDWNG 194

  Fly   173 T----------TARMAYRYGITPIFGIEVNKDLASNTRNRIYLGQQDFPLEARSMYVDDATAVYR 227
            |          .:.:.|::....:..|.|..|...::::.||:.|....:.:|..|.:
 Frog   195 TKESNWSLEEKLSLLNYKFNKRVLVDIFVWNDDRESSKHIIYIDQPSLGMPSRDYYFN------- 252

  Fly   228 QKYRNNIQRILQRYLGVKMDLAKKTAKE----------------LIDFEVDLAQGLVDESEGLDV 276
               :.|.|||.:.||...:.:|:...::                ::|.|.|:|:......|..||
 Frog   253 ---KGNYQRIREAYLQFMITIARMVREDRNLTRDDSLVQEEMTRVMDLETDIARATAPSEERNDV 314

  Fly   277 GELTQLLTVDEIQRRYSPTLDIDRLLF-------VSMGERISDQIYEYNNRYQQNLVEVIKRTPK 334
            ..|...:|:.|.|::::.. |.:...|       |::..:..:::..|...|...|..::.....
 Frog   315 TLLYNKMTLLEFQQKFALD-DFNWTSFIQGVMSSVNIQLQAEEEVVVYGAPYLHQLKNILSNYSA 378

  Fly   335 RTVANYIFFRLIWEFVETPS----DSPEKQMKACVDLTKK---------YFAKNLDNMFYRRYNN 386
            .|:.||:.:|::.:.|.:.|    |:.....||....|.:         |...|::|.....|..
 Frog   379 STLQNYVVWRMVIDRVSSLSRRYKDARASYRKALYGTTLEEARWRECVSYVNSNMENAVGAMYVK 443

  Fly   387 E----KSSREIDNMWRQLKSTFNETLRSSPALNWIERPTRNLAMAKLQAMTLEVNNYAD------ 441
            |    :|.|.|.::..:::..|.|||   ..|.|::..:::.|..|..::..:: .|.|
 Frog   444 ETFAGESKRMISDLINKVREAFIETL---DELQWMDETSKDKAREKALSIKEQI-GYPDYILEDQ 504

  Fly   442 -DNFTEEFAELNLQSDDYVENVRYTSLLGA----KQMREMLHKPAKPFEAG-SQLSYTPANILIE 500
             |...:|.|.||.....|.||:......||    |::||.:.:.|....|. :...|:|.    .
 Frog   505 NDKLDQETAALNFSEYQYFENILEILNSGAQKSLKKLREPVDQDAWIIGAAVADAFYSPN----R 565

  Fly   501 NTIKVPVALLQPFYIWSDVYPNAIMFGTLASLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSN 565
            |.|..|..:|||.: ::...|.|:.||.:..:||||:.|||||:||.||:.||..|||...|:.:
 Frog   566 NQIVFPAGILQPPF-FNKHQPQALNFGGIGMVIGHEITHGFDDNGRNFDKDGNMFDWWSNFSAMH 629

  Fly   566 FLKRRDCFTKQYGRYVYD---GIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDM 627
            |..:..|...|||.|.::   |..:.......||||||||:|.||.||.||.|.....|.
 Frog   630 FKDQSRCMVYQYGNYTWELAGGQNVSGIITLGENIADNGGVRQAYKAYLKWVERHGKEPK----- 689

  Fly   628 TKETLPNLRYTAKQLFFISFAQSWCNDAHPSVKALQVSTDQHMPGRFRVIGSLSNFEEFSKEFNC 692
                ||.|..|.|||||::|||.||....|......:.||.|.|.::||:|||.|||.|::||||
 Frog   690 ----LPGLDLTYKQLFFLNFAQVWCGSYRPEYARHSIKTDVHSPFKYRVMGSLQNFEAFAEEFNC 750

  Fly   693 PAGSAMNPSEKC 704
            ..|:.|:|.|||
 Frog   751 KKGTKMHPVEKC 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	M13	63..704	CDD:341056	200/715 (28%)
mmel1	XP_012821551.1	M13	95..763	CDD:341056	202/717 (28%)