DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl20 and ECEL1

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_004817.2	Gene:	ECEL1 / 9427	HGNCID:	3147	Length:	775	Species:	Homo sapiens

Alignment Length:	734	Identity:	202/734 - (27%)
Similarity:	339/734 - (46%)	Gaps:	125/734 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PYMKELMRQAK--AAEIESFMNQKVDPCKDFYAFSCGNYKRINSALNMRVLTTGVFETLTKGLNR 96
            |..|...|.|:  ||.:::    .:|||:|||:|:||.:.| ..|:....||.|....:.:....
Human   100 PERKAFARAARFLAANLDA----SIDPCQDFYSFACGGWLR-RHAIPDDKLTYGTIAAIGEQNEE 159

  Fly    97 KILKMLNTPHDSHDTPEDIQVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQEDDF 161
            ::.::|..|..........:|:.|:.|||.::|:     |:|       |..|:||..   ||..
Human   160 RLRRLLARPGGGPGGAAQRKVRAFFRSCLDMREI-----ERL-------GPRPMLEVI---EDCG 209

  Fly   162 DW----------------LNTTARMAHR----YGIMSIIGVGVATDFANNQKNIIYINQQEFPLK 206
            .|                ||   |:.::    |...::..:.|:.|..|:.:.:|.|:|....|.
Human   210 GWDLGGAEERPGVAARWDLN---RLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLP 271

  Fly   207 TRSMYM----DNE--TAIYRQNYQNNIQLILEKYLGV--KDELARKAAKEMFEFEVDLAHGLVDN 263
            .|::|:    |:|  .|.||        :.:|:.|.:  .|.:.:| |:|:.:.|..||:..|..
Human   272 ERTLYLAQDEDSEKILAAYR--------VFMERVLSLLGADAVEQK-AQEILQVEQQLANITVSE 327

  Fly   264 NKHLNLRDLIEL---LTVAELRERYAPTLD----TDQLIFVSMGEKISDKVYEYNRRYQQNLVEV 321
            :..|. ||:..:   :|:.:| ::..|.|.    .||:......|:  ::|......|.|.:.::
Human   328 HDDLR-RDVSSMYNKVTLGQL-QKITPHLRWKWLLDQIFQEDFSEE--EEVVLLATDYMQQVSQL 388

  Fly   322 IERTPKSTVANYLFLRLI---------------WEFIQKPSGVAEKPTE---ACVDFTKTYFAKN 368
            |..||...:.|||..|::               .|..|:..| ::||.|   .|:.....:|...
Human   389 IRSTPHRVLHNYLVWRVVVVLSEHLSPPFREALHELAQEMEG-SDKPQELARVCLGQANRHFGMA 452

  Fly   369 LDNMIYRRYKNEKSSREIDSMWHQLKSTFKETLLSSPALDWIEPSTRSLAIAKLEAMTLEV---N 430
            |..:....:.:..|..::..:...:|....:.|   ..|||::..||:.|.|||:.|.:.|   :
Human   453 LGALFVHEHFSAASKAKVQQLVEDIKYILGQRL---EELDWMDAETRAAARAKLQYMMVMVGYPD 514

  Fly   431 NYVKENFTEEFADLNLQNTDCVEN----LRQVQMLQAKQMRQ-----LYHQPAKPLEAGELLSYT 486
            ..:|.:..::..:..:......:|    :|....|..|::||     .:..|.:.|.|    .|.
Human   515 FLLKPDAVDKEYEFEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKSTWLLPPQALNA----YYL 575

  Fly   487 PSNILLENSIKVPVALLQPFYIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWW 551
            |:    :|.:..|..:||| .::...:|.::.:|.:..:|||||.||:||.|.::|..||...||
Human   576 PN----KNQMVFPAGILQP-TLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWW 635

  Fly   552 DEKSSSNFLKRRDCFTKQYGRYVYDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNG 616
            .|.|.|.||::.:|..:.|..:.....::.......|||||.||::|||.||:||...     :|
Human   636 TEASYSRFLRKAECIVRLYDNFTVYNQRVNGKHTLGENIADMGGLKLAYHAYQKWVRE-----HG 695

  Fly   617 AQDMTKETLPNLRYTAKQLFFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSK 681
            .:    ..||.|:||..|||||:|||:||.....:...|||.||.|.|..:||:|::|.||||.:
Human   696 PE----HPLPRLKYTHDQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGR 756

  Fly   682 EFNCHAGSAMNPIEKCILY 700
            .|:|...|.|||..||.::
Human   757 AFHCPKDSPMNPAHKCSVW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	191/705 (27%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	194/705 (28%)
ECEL1	NP_004817.2	M13	120..773	CDD:341056	195/706 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150985
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850