DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl20 and ece2b

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_017206531.1	Gene:	ece2b / 793465	ZFINID:	ZDB-GENE-131120-140	Length:	794	Species:	Danio rerio

Alignment Length:	731	Identity:	196/731 - (26%)
Similarity:	329/731 - (45%)	Gaps:	121/731 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 AAEIESFMNQKVDPCKDFYAFSCGNYKRINSALNMRVLTTGVFETLTKGLNRKILKML--NTPHD 107
            |::|...:::..|||:|||.::||.:.|.|...:.| .....|.::. ..|:.:||.|  |...:
Zfish   104 ASKIVEALDRSADPCQDFYQYACGGWVRKNPLPDGR-SRWSTFNSIW-DQNQAVLKHLLENGTFN 166

  Fly   108 SHDTPEDIQVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQEDDFDWLNTTARMAH 172
            |....|. :.:.:|.|||..:.:....::.|..||.:.|...:.|  ||.:::|  |:....::.
Zfish   167 SSSEAER-KTQSYYLSCLNEQRIEELGAQPLMDLITKIGGWNITE--SWDKENF--LDVLKIISG 226

  Fly   173 RYGIMSIIGVGVATDFANNQKNIIYINQQEFPLKTRSMYMDNETAIYRQNYQNNIQLILEKYLGV 237
            .|.......|.|:.|..|:..|:|.::|....|.:|..|: |:|.          :.:|:.||..
Zfish   227 PYRAQPFFTVSVSVDPKNSNSNVIQVDQSGLFLPSRDYYL-NKTN----------EKVLKAYLDY 280

  Fly   238 KDEL----------ARKAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRERYAPTLD-T 291
            ..||          .|...:::.:||..||:..|..::..:...:...:|:|:| :..||.:: .
Zfish   281 MVELGLLLGGDKNSTRGQMQQILDFETALANITVPQDERRDEEKIYHKITIADL-QVLAPAIEWL 344

  Fly   292 DQLIFVSMGEKISD--KVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLIWEFIQKPSGVAEKPT 354
            |.|..|....:::|  .|..|.:.|.|.:.|:|.:|..|.:.||    :||..:||.:...::..
Zfish   345 DYLNSVLSPLELNDTEPVVVYAKEYMQQVSELINKTDHSLLNNY----MIWNLVQKGASSLDQRF 405

  Fly   355 E---------------ACVDFTKTYFAKNLDNM------IYRRYKNEKSSREID----------- 387
            |               :|....:|......|.:      ::.:...:|.|:|||
Zfish   406 ENAQDKLLESLYGTKKSCTPRWQTCIGNTDDTLGFALGALFVKATFDKQSKEIDLNGGAFLPSCG 470

  Fly   388 -------------------SMWHQLKSTFKETLLSSPALDWIEPSTRSLAIAKLEAM--TLEVNN 431
                               .|.:::::.||..|   ..|.|::..||..|..|.:|:  .:...:
Zfish   471 RNVNSTVHNLMFSVITQAEGMINEIRTAFKGAL---DDLKWMDEQTRQAAKDKADAIYDMIGFPD 532

  Fly   432 YVKENFTEEFADL----NLQNTDCVENLRQVQMLQAKQMRQLYHQPAKPLEAGELLSYTPSNI-- 490
            ::.:  ::|..|:    .:...:..:|:.......|:.|.....:|..    .:..|.||..:
Zfish   533 FILD--SKELDDVYDGYEVTEDNFFQNMINFYNFSARVMADQLRKPPN----RDQWSMTPPTVNA 591

  Fly   491 ---LLENSIKVPVALLQ-PFYIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWW 551
               ..:|.|..|..:|| |||  :..:|.|:.||.:..::||||.|.|||.||::|:.||.:.||
Zfish   592 YYMPTKNGIVFPAGILQAPFY--AQDHPKALNFGGIGVVMGHELTHAFDDQGREYDKDGNLRSWW 654

  Fly   552 DEKSSSNFLKRRDCFTKQYGRYVYDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNG 616
            ...|...|..|.:|...||.:|..:|..:.......||||||||::.||.|||.|.:.     ||
Zfish   655 QNSSVEAFKNRTECMVDQYTQYTINGEHINGKQTLGENIADNGGLKAAYHAYRSWVQK-----NG 714

  Fly   617 AQDMTKETLPNLRYTAKQLFFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSK 681
            .:    :.||.:..|..||||:.|||.||:...|:.....:.||.|.|.|:||||||||..||::
Zfish   715 EE----KRLPAVNLTNDQLFFVGFAQVWCSVRTPESAHEGLMTDPHSPPKYRVIGTLSNSPEFAE 775

  Fly   682 EFNCHAGSAMNPIEKC 697
            .|.|..||:||...:|
Zfish   776 HFQCPLGSSMNSGHRC 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	191/718 (27%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	193/718 (27%)
ece2b	XP_017206531.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585580
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950