Protein Alignment Nepl20 and MMEL1

DIOPT Version :9

• Sequence 1: NP_651645.1
• Gene: Nepl20 / 43412
• FlyBaseID: FBgn0039613
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_258428.2
• Gene: MMEL1 / 79258
• HGNCID: 14668
• Length: 779
• Species: Homo sapiens
• Alignment Length: 712
• Identity: 198/712 - (27%)
• Similarity: 327/712 - (45%)
• Gaps: 92/712 - (12%)

  Fly    45 AAEIESFMNQKVDPCKDFYAFSCGNYKR--INSALNMRVLTTGVFETLTKGLNRKILKMLNTPHD 107
            ||.|...|:...:||.|||.|:||.:.|  :....|.|.   .:|:.|...| ..|||.:.....
Human    98 AARILQNMDPTTEPCDDFYQFACGGWLRRHVIPETNSRY---SIFDVLRDEL-EVILKAVLENST 158

  Fly   108 SHDTPEDIQVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQED---DFDWLNTTAR 169
            :.|.|...:.:..|.||:....:....|:.|..::...|..|:.. ..|.|.   :::.....|.
Human   159 AKDRPAVEKARTLYRSCMNQSVIEKRGSQPLLDILEVVGGWPVAM-DRWNETVGLEWELERQLAL 222

  Fly   170 MAHRYGIMSIIGVGVATDFANNQKNIIYINQQEFPLKTRSMYMDNET-----AIYRQNYQNNIQL 229
            |..::....:|.:.:..|..|:.::||||:|....:.:|..|.:..:     ..|.|...:...|
Human   223 MNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQPTLGMPSREYYFNGGSNRKVREAYLQFMVSVATL 287

  Fly   230 ILEKYLGVKDE-LARKAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRERYAP-----T 288
            :.|.....:|. |.::...::.|.|..||...|...:..::..|...:.:.||:.::..     |
Human   288 LREDANLPRDSCLVQEDMVQVLELETQLAKATVPQEERHDVIALYHRMGLEELQSQFGLKGFNWT 352

  Fly   289 LDTDQLIFVSMGEKI--SDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLIWEFIQKPSGVAE 351
            |.. |.:..|:..|:  .::|..|...|.|||..:|:.....|:.|||..||:   :.:...:::
Human   353 LFI-QTVLSSVKIKLLPDEEVVVYGIPYLQNLENIIDTYSARTIQNYLVWRLV---LDRIGSLSQ 413

  Fly   352 KPTEACVDFTKTYFA----------------KNLDNMIYRRYKNEKSSREIDSMWHQL----KST 396
            :..:..|::.|..|.                .|::|.:...|..|....:..||..:|    ::.
Human   414 RFKDTRVNYRKALFGTMVEEVRWRECVGYVNSNMENAVGSLYVREAFPGDSKSMVRELIDKVRTV 478

  Fly   397 FKETLLSSPALDWIEPSTRSLAIAKLEAMTLEVN--NYVKENFT----EEFADLN----LQNTDC 451
            |.|||   ..|.|::..::..|..|..::..::.  :|:.|...    ||:::||    |...:.
Human   479 FVETL---DELGWMDEESKKKAQEKAMSIREQIGHPDYILEEMNRRLDEEYSNLNFSEDLYFENS 540

  Fly   452 VENL-----RQVQMLQAKQMRQLYHQPAKPLEAGELLSYTPSNILLENSIKVPVALLQPFYIWSD 511
            ::||     |.::.|:.|....|:...|..:.|    .|:|:    .|.|..|..:|||.: :|.
Human   541 LQNLKVGAQRSLRKLREKVDPNLWIIGAAVVNA----FYSPN----RNQIVFPAGILQPPF-FSK 596

  Fly   512 VYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYD 576
            ..|.|:.||.:..:||||:.|||||:||.||:.||..|||...|:.:|.::.:|...|||.|.:|
Human   597 EQPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNFSTQHFREQSECMIYQYGNYSWD 661

  Fly   577 GIQLKES------TAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQL 635
               |.:.      ....||||||||:|.||.||.||      :..|.:|   :.||.|..|.:||
Human   662 ---LADEQNVNGFNTLGENIADNGGVRQAYKAYLKW------MAEGGKD---QQLPGLDLTHEQL 714

  Fly   636 FFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKC 697
            |||::||.||....|:.....:.||.|.|.|:||:|:|.|...|:..|:|..|:.|:|.|:|
Human   715 FFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMHPKERC 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	191/699 (27%)
		M13	56..697	CDD:189000	193/699 (28%)
MMEL1	NP_258428.2	PepO	102..779	CDD:226118	195/708 (28%)
		M13	111..777	CDD:189000	194/699 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150997
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850