DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl20 and ece1

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001071260.1	Gene:	ece1 / 777750	ZFINID:	ZDB-GENE-061110-100	Length:	752	Species:	Danio rerio

Alignment Length:	705	Identity:	205/705 - (29%)
Similarity:	322/705 - (45%)	Gaps:	91/705 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 AAEIESFMNQKVDPCKDFYAFSCGNYKRINSALNMRVLTTGVFETLTKGLNRKILKML--NTPHD 107
            |:.:...:::.||||:|||.|:||.:.|.| .|.......|.|..|.:. |..::|.|  ||...
Zfish    90 ASAVLGSLDRSVDPCQDFYNFACGGWMRKN-PLPEGKSRWGPFSNLWEH-NMAVMKNLLENTSMK 152

  Fly   108 SHDTPEDIQVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQEDDFDWLNTTARMAH 172
            |....|. :.:.:|::|:...::....::.|:.||.:.|...|  ...|::|:|.  .....::.
Zfish   153 SLSRAEQ-KAQWYYQACMNESKIEELGAKPLQDLINQTGGWGL--KGPWEKDNFQ--EVLRIVSA 212

  Fly   173 RYGIMSIIGVGVATDFANNQKNIIYINQQEFPLKTRSMYMDNETAIYRQNYQN---NIQLILEKY 234
            .:.......|.|:||..::..|||.::|....|.:|..|: |:||  .:.|.|   |..:.|...
Zfish   213 NFRTSPFFTVFVSTDSKSSNSNIIQVDQSGLGLPSREYYL-NKTA--NEKYLNAYLNFLVELGVL 274

  Fly   235 LGVKDELARKAAKEMFEFEVDLAHGLV------DNNKHLNLRDLIELLTVAELRERYAPTLDTDQ 293
            ||...:.::|..:|:.|||..||:..|      |..|........||.|:|...: :.|.|.:
Zfish   275 LGGSQDTSQKMMEEIIEFETTLANITVPQVERRDEEKIYYKIQAKELATLAPAID-WMPFLSS-- 336

  Fly   294 LIFVSMGEKISDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLIWEFI----QKPSGVAEKPT 354
             :|..:....|:.|..|.:.|.|.:.|:|..|.||.:.||:.::::.:.:    ||.....::..
Zfish   337 -VFAPVELNNSEPVVVYAKEYLQKVSELISNTNKSVLNNYMIMKVVRKMVSILDQKFQDAEQRFL 400

  Fly   355 EA--------------CVDFTKTYFAKNLDNMIYRRYKNEKSSREIDSMWHQLKSTFKETLLSSP 405
            |.              ||..|.:.....|..:..:...:|.|...::.|..::|..|:::|   .
Zfish   401 EVMYGTKKSCMPRWKLCVSDTDSALGFALGALFVKATFSEDSKAFVEDMVSEIKWAFEDSL---K 462

  Fly   406 ALDWIEPSTRSLAIAKLEAMTLEVNNYV---------KE-----NFTEEFADLNLQNTDCVENLR 456
            .:.|::|.|:..|..|.:|    :.|.|         ||     |..:..:||..||.....|..
Zfish   463 TVSWMDPETKKAAKEKADA----IYNMVGYPKFIMNPKELDKVFNDFDVVSDLYFQNVMNYYNFS 523

  Fly   457 QVQMLQAKQMRQLYHQPAKPLEAGELLSYTPSNI-----LLENSIKVPVALLQ-PFYIWSDVYPN 515
              ..:.|.|:|:..::        :..|.||..:     ..:|.:.:|..:.| |||  :..:|.
Zfish   524 --ARVTADQLRKAPNR--------DQWSMTPPTVNAYYNPTKNEMVLPAGIFQAPFY--NHAWPK 576

  Fly   516 AVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYDGIQL 580
            |:.||.:..::||||.|.|||.|||:|:.||...||...|...|..:..|..:||..|..:...|
Zfish   577 AMNFGGIGVVMGHELTHAFDDQGRKYDKDGNLAKWWQNSSVEAFQHQTQCMVEQYSNYSINNEPL 641

  Fly   581 KESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWC 645
            .......||||||||:..||.||..|.:.     ||.:    .:||.|.....||||:.|||.||
Zfish   642 NGKHTLGENIADNGGLNAAYKAYVNWIKK-----NGEE----ASLPALGMNNHQLFFVGFAQVWC 697

  Fly   646 NDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKCILY 700
            :...|:.....|.||.|.|.:||||||:||..|||:.|.|.|.|.|||..||.|:
Zfish   698 SVRTPESSHEGVITDPHSPSRFRVIGTISNSHEFSEHFGCKADSPMNPKRKCELW 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	198/689 (29%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	201/689 (29%)
ece1	NP_001071260.1	PepO	94..752	CDD:226118	203/699 (29%)
ece1	NP_001071260.1	M13	101..750	CDD:189000	202/690 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585570
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950