Protein Alignment Nepl20 and mmel1

DIOPT Version :10

• Sequence 1: NP_651645.1
• Gene: Nepl20 / 43412
• FlyBaseID: FBgn0039613
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: XP_017213856.1
• Gene: mmel1 / 560703
• ZFINID: ZDB-GENE-101112-2
• Length: 765
• Species: Danio rerio
• Alignment Length: 737
• Identity: 197/737 - (26%)
• Similarity: 318/737 - (43%)
• Gaps: 142/737 - (19%)

  Fly    45 AAEIESFMNQKVDPCKDFYAFSCGNY---------KRINSALN-----MRVLTTGVFETLTKGLN 95
            ||.:...|:..||||::||.::||.:         ..::|..|     :.::..||.|...|. :
Zfish    84 AARLLQNMDPSVDPCQNFYQYACGGWIERHVIPETSSLHSVFNILRDELEIVLKGVLEMENKD-D 147

  Fly    96 RKILKMLNTPHDSHDTPEDIQVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLL----EGSS- 155
            |:..|               :.|..|.||:....:....|:.|.|||...|..|:.    .|:|
Zfish   148 REAFK---------------KAKTLYSSCMNEILIEQRDSQPLLRLIDSIGDWPVASEVWNGTSE 197

  Fly   156 --WQEDDFDWLNTTARMAHRYGIMSIIGVGVATDFANNQKNIIYINQQEFPLKTRSMYMDNETAI 218
              |..:|     |.|.:..||...:::.:.|..|..::.:.||:::|....:.:|..|:.:
Zfish   198 QTWSLED-----TLAVLNGRYNKKAVLEMFVWPDDRDSSRYIIHVDQPALGMPSRDYYLSD---- 253

  Fly   219 YRQNYQNNIQLILEKYLGVKDELARKAAK----------------EMFEFEVDLAHGLVDNNKHL 267
                  .|.:.:.|.||.....:||.|.:                ::.|.|.|:|:......:..
Zfish   254 ------GNYKKVREAYLEFMVSMARIAREDRNLTQDEERVLEDMSQVLELETDIANATSPAEERN 312

  Fly   268 NLRDLIELLTVAELRE----------RYAPTLDTDQLIFVSMGEKISDKVYEYNRRYQQNLVEVI 322
            ::..|...:|:.|.::          ||...:    :..||:..:..:.:..|...|.:.|.||:
Zfish   313 DITVLYNKMTLREAQQTFNLNGFNWTRYIQGI----MSSVSISVQSDEPIVIYCSPYLEKLSEVL 373

  Fly   323 ERTPKSTVANYLFLRLIWEFIQKPS-----------------GVAEKPTEACVDFTKTYFAKNLD 370
            .:....|:.|||...||.:.:...|                 .|.|.....||    .|...|::
Zfish   374 SKHSHRTLQNYLVWMLIMDRVSSMSRRFKDVRAHYRKALHGTTVEEARWRDCV----RYVQGNME 434

  Fly   371 NMIYRRYKNE----KSSREIDSMWHQLKSTFKETLLSSPALDWIEPSTRSLAIAKLEAMT----- 426
            |.:...|..|    .|.|.:..:..:::..:.|||   ..|.|::..::..|..|..|::
Zfish   435 NAVGALYVRETFSGNSKRMVGELIKKIQEAYVETL---EELSWMDEQSKVKAREKAMAISEQIGY 496

  Fly   427 ----LEVNNYVKENFTEEFADLNLQNTDCVENLRQVQMLQAKQMRQLYHQPAKP----LEAGELL 483
                ||..|   :...:|:|.||....:..||:.:.....|::..:...:|..|    :.|..:.
Zfish   497 PDHILEEEN---KKLDQEYAHLNFSEENYFENILENLAASAQKGHKKLREPVDPDMWIIGAAVVN 558

  Fly   484 SYTPSNILLENSIKVPVALLQPFYIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSK 548
            ::...|   .|.|..|..:|||.: :|:....|:.||.:..:||||:.|||||.||.||:.||..
Zfish   559 AFYSHN---RNQIVFPAGILQPPF-FSEKQLQALNFGGIGMVIGHEITHGFDDHGRNFDKDGNMY 619

  Fly   549 DWWDEKSSSNFLKRRDCFTKQYGRYVY---DGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQ 610
            :||...|:..|..:..|..:||||:.:   .|..:...|...||||||||:|.||.||.||.|.:
Zfish   620 NWWSNYSAERFEDQSKCMVEQYGRFSWKLAGGQNVSGITTLGENIADNGGVRQAYKAYVKWVERE 684

  Fly   611 LTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSN 675
            ...|.         ||.|....|||||::|||.||....|:.....:.||.|.|.::||:|:|.|
Zfish   685 GEEPR---------LPGLDMNHKQLFFLNFAQVWCGACRPEYAIQTIKTDPHSPLEYRVLGSLQN 740

  Fly   676 FEEFSKEFNCHAGSAMNPIEKC 697
            ||.||:.|:|..|:.|||.|||
Zfish   741 FEAFSEAFHCARGAPMNPEEKC 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	M13	56..697	CDD:341056	192/724 (27%)
mmel1	XP_017213856.1	M13	95..763	CDD:341056	194/726 (27%)