DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl20 and MME

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_000893.2	Gene:	MME / 4311	HGNCID:	7154	Length:	750	Species:	Homo sapiens

Alignment Length:	765	Identity:	201/765 - (26%)
Similarity:	344/765 - (44%)	Gaps:	130/765 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LSVLVLAA-----------PTSEDVLNQDTPYMKELMRQAKAAEIESFMNQKVDPCKDFYAFSCG 68
            ||||||..           .|.:|.:.:.:..:|      .||.:...|:...:||.||:.::||
Human    31 LSVLVLLLTIIAVTMIALYATYDDGICKSSDCIK------SAARLIQNMDATTEPCTDFFKYACG 89

  Fly    69 NYKRINSALNMRVLTTGVFETLTKGLNRKILKMLNTPHDSHDTPEDI----QVKHFYESCLQIKE 129
            .:.:.| .:.......|.|:.|...|...:..:|..|     ..|||    :.|..|.||:....
Human    90 GWLKRN-VIPETSSRYGNFDILRDELEVVLKDVLQEP-----KTEDIVAVQKAKALYRSCINESA 148

  Fly   130 LNSTYSEKLKRLIAEFGTMPLLE-------GSSWQEDDFDWLNTTARMAHRYGIMSIIGVGVATD 187
            ::|...|.|.:|:.:....|:..       |:||..:     ...|::..:||...:|.:.|.||
Human   149 IDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAE-----KAIAQLNSKYGKKVLINLFVGTD 208

  Fly   188 FANNQKNIIYINQQEFPLKTRSMYMDNETAIYRQNYQNNIQLIL--------EKYLGV-KDELAR 243
            ..|:..::|:|:|....|.:|..|  ..|.||::.....:..::        |:.|.: :::||.
Human   209 DKNSVNHVIHIDQPRLGLPSRDYY--ECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQLAL 271

  Fly   244 KAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRERYAPTLDTDQLIFVSMGEKI----- 303
            :..|.| |.|.::|:.........:...|...:|:|:::..::..::.....:::...:|
Human   272 EMNKVM-ELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVN 335

  Fly   304 -----SDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLIWEFIQKPSGVAEKPTEACVDFTK- 362
                 .:.|..|...|...|..::.:.....:.|.:..|.|.:.:...|...::...|   |.|
Human   336 ISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNA---FRKA 397

  Fly   363 ---------------TYFAKNLDNMIYRRYKNE----KSSREIDSMWHQLKSTFKETLLSSPALD 408
                           .|...|::|.:.|.|...    :|...::.:..|::..|.:||   ..|.
Human   398 LYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTL---DDLT 459

  Fly   409 WIEPSTRSLAIAKLEAMTLE---------VNNYVKENFTEEFADLNLQNTDCVENLRQ-VQMLQA 463
            |::..|:..|..|  |:.::         |:|..|.|  .|:.:||.:..:..||:.| ::..|:
Human   460 WMDAETKKRAEEK--ALAIKERIGYPDDIVSNDNKLN--NEYLELNYKEDEYFENIIQNLKFSQS 520

  Fly   464 KQMRQLYHQPAKPLEAGELLS--------YTPSNILLENSIKVPVALLQPFYIWSDVYPNAVMFG 520
            ||:::|    .:.::..|.:|        |:..    .|.|..|..:|||.: :|....|::.:|
Human   521 KQLKKL----REKVDKDEWISGAAVVNAFYSSG----RNQIVFPAGILQPPF-FSAQQSNSLNYG 576

  Fly   521 TLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYD---GIQLKE 582
            .:..:||||:.|||||:||.|::.|:..|||.::|:|||.::..|...|||.:.:|   |..|..
Human   577 GIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNG 641

  Fly   583 STAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCND 647
            .....||||||||:..||.||:.:.:.     ||.:.:    ||.|....|||||::|||.||..
Human   642 INTLGENIADNGGLGQAYRAYQNYIKK-----NGEEKL----LPGLDLNHKQLFFLNFAQVWCGT 697

  Fly   648 VHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKC 697
            ..|:.....:.||.|.||.||:||||.|..|||:.|:|...|.|||.:||
Human   698 YRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKC 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	185/711 (26%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	187/711 (26%)
MME	NP_000893.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:189000	189/711 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150934
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850