DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl20 and Nepl14

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_651097.1	Gene:	Nepl14 / 42700	FlyBaseID:	FBgn0039023	Length:	696	Species:	Drosophila melanogaster

Alignment Length:	745	Identity:	194/745 - (26%)
Similarity:	355/745 - (47%)	Gaps:	102/745 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TMKLFCIWIASHVLSVLVLAAPTSEDVLNQDTPYMK-----ELMRQAKAAEIESFMNQKVDPCKD 61
            |:.|:.:|:.....:.||    :.||:   ..|:.:     :.:|::||.::.|.:|:.:|||.|
  Fly     8 TVFLWLLWLPHLQQNALV----SGEDL---PPPFQRIYQSEQTVRRSKAQDMGSHVNKSIDPCVD 65

  Fly    62 FYAFSCGNYKRINSALNMRVLTTGVFETLTKGLNRKILKMLNTPHDSHDTPEDIQVKHFYESCLQ 126
            |||::|||:|   |.|..:       :.|.:..:|::|.::.......|:....|.|..::||:.
  Fly    66 FYAYACGNWK---STLTPQ-------QQLQQQTDRELLLLVEEAVRREDSVIVRQAKELFKSCVS 120

  Fly   127 IKELNSTYSEKLKRLIAEF----GTMPLLEGSSW--QEDDFDWLNTTARMAHRYGIMSIIGVGVA 185
            .:   :..|::.:..::||    |..|.:.||.|  ...|::||:....:..|||:..:||:.|.
  Fly   121 AQ---AHQSQQQQHFLSEFINQNGGFPAVPGSQWAVHHHDYNWLSVLGGLRLRYGMDILIGLRVG 182

  Fly   186 TDFANNQKNIIYINQ------QEFPLKTRSMYMDNETAIYRQNYQNNIQLILEKYLGV-KDELAR 243
            .::.|..:|.:|:::      .|...:.||   |...:|| :..::.:...|:.:|.: .||.||
  Fly   183 YNYGNVNENSLYLSEPSTLIPTELCTRNRS---DIRDSIY-EPLEHRVASELKSWLALGHDESAR 243

  Fly   244 KAAKEMFEFEVDLAHGLV-------DNNKHLNLRDLIELLTVAELRE-RYAPTLDTDQLIFVSMG 300
            .|| ::..||.:|..|:.       |..:.|.|.:    .|...||| ..:..||.|..:..|.|
  Fly   244 LAA-DILSFEHELCGGMKGGSFESWDAEEQLYLAN----YTRKTLREFSNSIELDLDSYVRASFG 303

  Fly   301 EKISDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLIWEFIQKPSGVAEKP---TEACVDFTK 362
            :.|...||.....|.:.|...:.....|.||||:..|.: ..:..|  :.::|   ...|::.||
  Fly   304 QDIYKPVYMAAPEYFRQLKRTVSAHNISLVANYIMYRAV-SALNFP--LDDRPQLRKRECLERTK 365

  Fly   363 TYFAKNLDNMIYRRYKNEKSSREIDSMWHQLKSTFKETLLSSPALDWIEPSTRSLAIAKLEAMTL 427
            ......|..:..|::..|....::|:::..||:..:::|    ..:|:...|:.:...||..:.|
  Fly   366 ELLPTALGELYARQFGTEDGRIDLDNLYDTLKTALRQSL----GAEWLVEGTQRVGQEKLRNLKL 426

  Fly   428 EVNNYVKENFTEEFADLNLQNTDCVENLRQ-VQMLQAKQMRQLYHQ----PAKPLEAGEL-LSYT 486
            ::..|.:....:    |.|:..:..:|||| :.::|:::..:|:.:    |..|:||.|. :...
  Fly   427 QMPTYERPVILK----LQLERGNYWQNLRQLLGVVQSQRNNRLFEEFLPAPTDPVEAYEARVRLR 487

  Fly   487 PSNILLENSIKVPVALLQPFYIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFD--EKGNSKD 549
            |    ::..:.:.:||||| ..:...|.:|:.:.||...:..:|:..|||......  |:.|
  Fly   488 P----VQRRLDMGLALLQP-PAYDPRYGHAIRYATLGVQLAQQLVMAFDDPHWSVGLLERDN--- 544

  Fly   550 WWDEKSSSNFLKRRDCFTKQYGRYVYDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLP 614
             ||.:::..:..|.:||.:|...|:...:     :|.::.|.|:..:.:|:.||..|...|  .|
  Fly   545 -WDGQTAWQYHIRSNCFARQVDNYLRPNV-----SATTQLITDSAAINVAFRAYLTWLGFQ--EP 601

  Fly   615 NG-AQDMTKETLPNLRYTAKQLFFISFAQSWCN--DVHPKVKA------LQVSTDDHMPGKFRVI 670
            |. ...:||||||:|.|:...|||:::||..|:  :..|:.:.      |..:..:|...:..|.
  Fly   602 NNDFTKLTKETLPDLNYSNTALFFLAYAQEHCSLEEARPRDEQGTPEGYLYSARQNHTWTRLLVN 666

  Fly   671 GTLSNFEEFSKEFNCHAGSAMNPIEKCILY 700
            |.|.|..||:.||.|..||.|||..|||:|
  Fly   667 GPLRNSVEFASEFRCPIGSPMNPASKCIIY 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	176/681 (26%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	177/681 (26%)
Nepl14	NP_651097.1	M13	60..693	CDD:189000	177/681 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454947
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	1	1.000	-	-		FOG0007609
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850