DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl20 and Nepl13

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster

Alignment Length:	730	Identity:	174/730 - (23%)
Similarity:	320/730 - (43%)	Gaps:	103/730 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KELMRQAKAAEIESFMNQKVDPCKDFYAFSCGNYKRINS-ALNMRVLTTGVFETLTKGLNRKILK 100
            ::|:||..|.:::.:||...|||.||:.::||.:.|.:. .|....|:|......|| ::.::.:
  Fly    49 EQLVRQKIATDVQKYMNLSADPCTDFFEYACGQWGRYHKRQLRPDELSTAQQLMETK-ISEQLQQ 112

  Fly   101 MLNTPHDSHDTPEDI---------QVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSW 156
            :|..|......|...         :|:.|||||:.::...|.....|.:::.:.|.:..:..|:|
  Fly   113 LLTQPLPPQHHPNGYSGASMTNVRKVRAFYESCVAVEANASERRRFLMKILKDNGGLRNVPNSNW 177

  Fly   157 QEDDFDWLNTTARMAHRYGIMSIIGVGVATDFANNQKNIIYINQQEF---------PLKTRSMYM 212
            |.:. .|:.|...:...||:..::|:.:..:....:.|.||..:.:.         .|.||...:
  Fly   178 QHNR-QWVQTLGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKLTIIPAEHCNALATRGAQV 241

  Fly   213 DNETAIYRQNYQNNIQLILEKYLGVKDELARKAAKEMFEFEVDLA-------------------- 257
            .:|  :| :..|..:...|..:.|:....|.:.|.::..||.:|.
  Fly   242 RDE--VY-ELVQQQVTENLRDWFGMDTGEAARFAGDIIRFEFELCKQMGEQDIQKPEEEFPPAIQ 303

  Fly   258 ---HGLVDNNKHLNLRDLIELLTVAELRERYAPTLDTDQLIFVSMGEKISDKVYEYNRRYQQNLV 319
               :|.........||.....:|:.||.......||...|:.|.:..:...:||..:..|.:::|
  Fly   304 AQIYGARSRTGQERLRRQKGGMTLTELTSEMGNHLDFKMLVEVILESQYPSQVYLRSPEYVKHVV 368

  Fly   320 EVIERTPKSTVANYLFLRLIWEFIQKPSGVAEKPTEACVDFTKTYFAKNLDNMIYRRYKNEKSSR 384
            ..::...:.||..|:....:.|..|.|.....:....||..|:..|.:.|..|..|..:.:.:..
  Fly   369 RTVKANNRITVGGYILYVALNELNQPPEEAPSQRARQCVQVTQRLFPQVLGEMFQRHVQRDNAKH 433

  Fly   385 EIDSMWHQLKSTFKETLLSSPALDWIEPSTRSLAIAKLEAMTLEVNNYVKENFTEEFADLNLQNT 449
            ::|::::.:....:|..    .::|::.:.|..|..:|....:.:.:|...:.|    ||..|.:
  Fly   434 DLDAVFNDVIKALEEQF----HVEWMDENDRRAARTRLSQYRVSLPDYQSLDLT----DLQFQKS 490

  Fly   450 DCVENLRQVQM-LQAKQMRQL-------YHQPAKPLEAGEL-LSYTPSNILLENSIKVPVALLQ- 504
            :  :..|:::: |:.:..:|.       :.|.|..|:|.|: .:.:|.    :..:.|...|||
  Fly   491 E--DYWRRLEIALKYRSHQQFEALRGNDFGQDADGLDAFEVRAALSPR----QQMVLVGWGLLQA 549

  Fly   505 PFYIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQ 569
            |:|.:  .||.::.:..|.:.:...|:..|||.|  ::....:...|:|.:.|.:....:|...|
  Fly   550 PYYNY--YYPKSLKYALLGHRLASALVQAFDDEG--WNNHPQATAQWNEVTMSGYRNASECQRAQ 610

  Fly   570 YGRYVYD--GIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQD------MTKETLP 626
            |..|:|:  | :.:.:|...|.|||..|:.||:.||..|.|.        ||      :.||||.
  Fly   611 YSSYLYNEPG-EFRNATRLREIIADGSGLNLAFNAYLAWLEQ--------QDHKLRPLLAKETLS 666

  Fly   627 NLRYTAKQLFFISFAQS--WCND----VHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNC 685
            .|.:|..|||||.|||:  |..|    :...:..:|     |.|.::.|.|.|||..||.:||.|
  Fly   667 ELNFTNTQLFFIYFAQTRCWAKDNQDAILDSMPLMQ-----HTPERWDVNGPLSNSAEFGREFGC 726

  Fly   686 HAGSAMNPIEKCILY 700
            ..|:.||..:||::|
  Fly   727 ALGTPMNSGDKCLVY 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	165/706 (23%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	165/706 (23%)
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	165/705 (23%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	165/706 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454939
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	1	1.000	-	-		FOG0007609
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850