DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl20 and Nepl12

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_649924.1	Gene:	Nepl12 / 41172	FlyBaseID:	FBgn0037727	Length:	702	Species:	Drosophila melanogaster

Alignment Length:	781	Identity:	199/781 - (25%)
Similarity:	331/781 - (42%)	Gaps:	170/781 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MKLFCIW-IASHVLS-----VLVLAAPTSEDVLNQDTPYMKELMRQAKAAEIESFMNQKVDPCKD 61
            :.|..:| |.:.||:     .||..:..|:...:.......|...|..|..::|:|||.|:||::
  Fly     9 ISLMLLWVIVAAVLTDCEARSLVDRSENSDSNGSSTNRSAAEYQLQEYAEFMKSYMNQSVEPCEN 73

  Fly    62 FYAFSCGNYKRI-------NSALNMRVLTTGVFETLTKGLNR-KILKMLNTPHDSHDTPEDIQVK 118
            ||.::||||:.:       .|..|:..:|..:.:...:.|.| .:.:.||.      :.|....:
  Fly    74 FYEYACGNYRNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNV------SSELAVAQ 132

  Fly   119 HFYESCL--QIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQEDDFDWLNTTARMAHRYGIMSIIG 181
            .||.:||  .:...|:.....|. ||...|..|.::|.:|:..:|:|:|.:|.:|: ||...:|.
  Fly   133 RFYNACLGANLHPFNAADPAYLS-LIRSIGGFPAVDGDAWKASNFNWINMSAHLAN-YGANGLIR 195

  Fly   182 VGVATDFANNQKNIIYINQQEFPL----KTRSMYMD-----------NETAIYRQNYQNNIQLIL 231
            ..:               |..:|.    |...:..|           |.|..:|.|.:.     :
  Fly   196 ETL---------------QLRYPFEPYTKLPELGFDHIIVHEENISRNTTRAFRLNEER-----M 240

  Fly   232 EKYL---GVKDELARKAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRERYAPTLDTDQ 293
            ..||   |:.::..|:|...:|.|                .||.:|:....|:.:.|
  Fly   241 HGYLRAFGLPEDRIREAIAGVFAF----------------WRDALEIPPQCEVFDPY-------- 281

  Fly   294 LIFVSMGEKISDKVYEYNRR--------------YQQNLVEVIERTPKSTVANYLFLRLIWEFIQ 344
                .:........|.||..              |...|.:|..|..|: |||||.::|::.|..
  Fly   282 ----RIKRVFPQSEYYYNISWSGLHSTNKLFCDFYYVELDKVCARHRKA-VANYLAMKLLYRFDP 341

  Fly   345 KPSGVAEKPTEACVD--------FTKTYFAKNLDNMIYRRYKNEKSSREIDSMWHQLKSTFKETL 401
            |......:.....|.        |.|.|.|.|.         :|....|:..|..:|:.:.::.|
  Fly   342 KLKAPRYQRNYCSVTLYQSMRFLFNKLYMANNF---------SEAKRLEMSEMVRELRKSLRKAL 397

  Fly   402 LSSPALDWIEPSTRSLAIAK----------------LEAMTLEVNN--YVKENFTEEFADLNLQN 448
            ..:   ||::..:|:.|:.|                .:.:..|:|:  .:::.:.|  .::|||:
  Fly   398 EDA---DWLDAESRARALLKESRIQPRIGSFQDDALSDRIIREINSLKVIEDRYAE--TNINLQH 457

  Fly   449 TDCVENLRQVQMLQAKQMRQLYH--QPAKPLEAGELLS--YTPSNILLENSIKVPVALLQPFYIW 509
            .     :.|:....::..::|.:  :|.|.|...::.:  |||     :|||.|...:::| .|:
  Fly   458 L-----VVQINRFSSRHFQELTNDTKPQKILTGLQVGAGYYTP-----DNSINVMAGVVEP-PIY 511

  Fly   510 SDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYV 574
            ....|.::.||||.:::|||||||||.:...||..|:.:....|.|......|.:|:...||:|.
  Fly   512 QRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDRAECYMDYYGKYQ 576

  Fly   575 YDGI--QLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFF 637
            ...|  ::...|...||||||.|:|.|.||||.  ..|..|.:..|:...:.:|.|..|.:||||
  Fly   577 VPEISRRVNGKTTLDENIADNSGLRQALTAYRS--HRQQLLEHPGQERISDAMPGLDLTPEQLFF 639

  Fly   638 ISFAQSWCNDVHPK--VKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEK-CIL 699
            :.|||.:|:....:  .|.|   :|.|...:|||:|.|||.|:|...:||..||.|.|..| |.|
  Fly   640 LGFAQLFCSHYEEEHYWKGL---SDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRL 701

  Fly   700 Y 700
            :
  Fly   702 W 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	183/716 (26%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	182/717 (25%)
Nepl12	NP_649924.1	M13	68..700	CDD:189000	182/718 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451253
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6404
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.800