DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl20 and Ece2

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_006248635.1	Gene:	Ece2 / 408243	RGDID:	1303039	Length:	912	Species:	Rattus norvegicus

Alignment Length:	748	Identity:	213/748 - (28%)
Similarity:	345/748 - (46%)	Gaps:	118/748 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VLSVLVLAAPTSEDVLNQDTPYMKELMRQA---KAAEIESFMNQKVDPCKDFYAFSCGNYKRINS 75
            ||:.|:|....:..|.....|.....:.:|   .|.:|...:::.|.||:|||.||||.:.|.|.
  Rat   216 VLAALLLGCLVALWVQYHRDPVHSTCITEACIRVAGKILESLDRGVSPCQDFYQFSCGGWIRRNP 280

  Fly    76 ALNMRVLTTG-----VFETLTKGLNRKILKML--NTPHDSHDTPEDIQVKHFYESCLQIKELNST 133
                  |.:|     .|.:|. ..|:.|||.|  |:..:|....|. :.:.||.|||.::.:...
  Rat   281 ------LPSGRSRWNTFNSLW-DQNQAILKHLLENSTFNSSSEAER-KTRSFYLSCLHLERIEKL 337

  Fly   134 YSEKLKRLIAEFG----TMPLLEGSSWQEDDFDWLNTTARMAHRYGIMSIIGVGVATDFANNQKN 194
            .::.|:.||.:.|    |.|      |.||:|  :.....:|..|.......|.|..|..::..|
  Rat   338 GAKPLQDLIDKIGGWNITGP------WDEDNF--MEVLKAVAGTYRAAPFFTVYVGADSKSSNSN 394

  Fly   195 IIYINQQEFPLKTRSMYMDNETAIYRQNYQNNIQLILEKYLGVKDEL----------ARKAAKEM 249
            ||.::|....|.:|..|: |.||         .:.:|..||....||          .|...:::
  Rat   395 IIQVDQSGLFLPSRDYYL-NRTA---------NEKVLAAYLDYMVELGMLLGGQPTSTRAQMQQV 449

  Fly   250 FEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRERYAPTLDTDQLIFVS-------MGEKISDKV 307
            .|.|:.||...|..::..:...:...::::|| :..||::  |.|.|:|       :|:  |:.|
  Rat   450 LELEIQLATITVPQDQRRDEEKIYHKMSISEL-QTLAPSM--DWLEFLSFLLSPLELGD--SEPV 509

  Fly   308 YEYNRRYQQNLVEVIERTPKSTVANYLFLRLIWEFIQKPSGVAEKPTE---------------AC 357
            ..|...|.|.:.|:|.||..|.:.||    |||..:||.:...::..|               :|
  Rat   510 VVYGTEYLQQVSELINRTEPSILNNY----LIWNLVQKTTSSLDQRFETAQEKLLETLYGTKKSC 570

  Fly   358 VDFTKTYFAKNLDNM------IYRRYKNEKSSREI-DSMWHQLKSTFKETLLSSPALDWIEPSTR 415
            ....:|..:...|.:      ::.:...::.|:|| :.|..::::.|:|||.:   |.|::..||
  Rat   571 TPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRAAFEETLEN---LVWMDEKTR 632

  Fly   416 SLAIAKLEAM--TLEVNNYVKE--NFTEEFADLNLQNTDCVENLRQVQMLQAKQMR-QLYHQPAK 475
            ..|..|.:|:  .:...:::.|  ...:.:....:......:|:..:....||.|. ||...|::
  Rat   633 LAAKEKADAIYDMIGFPDFILEPRELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSR 697

  Fly   476 PLEAGELLSYTPSNI-----LLENSIKVPVALLQ-PFYIWSDVYPNAVMFGTLAYLIGHELIHGF 534
                 :..|.||..:     ..:|.|..|..:|| |||..:  :|.|:.||.:..::||||.|.|
  Rat   698 -----DQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHN--HPKALNFGGIGVVMGHELTHAF 755

  Fly   535 DDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYDGIQLKESTAQSENIADNGGMRLA 599
            ||.||::|::||.:.||..:|.:.|.....|..:||.:|..:|.:|.......||||||||::.|
  Rat   756 DDQGREYDQEGNLRPWWQNESLTAFQNHTACMEEQYNQYQVNGERLNGLQTLGENIADNGGLKAA 820

  Fly   600 YTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDVHPKVKALQVSTDDHMP 664
            |.||:.|...     :|.:    :.||.:..|..||||:.|||.||:...|:.....:.||.|.|
  Rat   821 YNAYKAWLRK-----HGEE----QPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSP 876

  Fly   665 GKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKC 697
            .:|||:|||||..:|.:.|.|..||.|||.:.|
  Rat   877 ARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLC 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	200/701 (29%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	203/701 (29%)
Ece2	XP_006248635.1	AdoMet_MTases	63..>128	CDD:302624
		PepO	250..903	CDD:226118	202/706 (29%)
		M13	261..910	CDD:189000	204/703 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344499
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850