DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl20 and Nep2

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster

Alignment Length:	789	Identity:	211/789 - (26%)
Similarity:	354/789 - (44%)	Gaps:	150/789 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FCIWI---------------ASHVLSVLVLAAPT----------SEDV-LNQDTPYMKELMRQAK 44
            |.:||               |.|..|..:...||          |.|| |.|:..:        .
  Fly    36 FGLWIGKVLRTSPPSNPQATALHGDSTTINQVPTGTASKGKSGDSGDVCLTQECIH--------T 92

  Fly    45 AAEIESFMNQKVDPCKDFYAFSCGNYKRINSALNMRVLTTGVFETLTKGLNRKILKMLNTPHDSH 109
            |:.:...|..:|:||.:||.|:||.|....:..:.:| :...|..::..|..::..::..
  Fly    93 ASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKV-SISTFSVISDKLQEQLKDIITA----- 151

  Fly   110 DTPEDIQVKHF------YESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQEDD-FDWLN-- 165
            :.|| .:.|||      |::|:....:.:...|.:.|:....|..||::|.||..|| :.|..
  Fly   152 ERPE-TEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDSWNADDSWTWQEQV 215

  Fly   166 ---TTARMAHRYGIMSIIGVGVATDFANNQKNIIYINQQEFPLKTRSMYMD-NE---TAIYRQNY 223
               .||..:..|    ||...:..|..|:.|.:|.::|....|....:... ||   ||.|:  |
  Fly   216 KKFRTAGFSMDY----IIDFSIGVDLQNSTKRLIDLDQSSLALSREYLVKGFNETLVTAYYK--Y 274

  Fly   224 QNNIQLILEKYLGVKDELARKAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRERYAPT 288
            ..:|.::    .|...:||:.......|||:.||:....|.|..|..:|..|.|.|:|:..|...
  Fly   275 MVDIAVL----FGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTPAQLQAAYPYV 335

  Fly   289 LDTDQL-------IFVSMGEKISDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLR--------L 338
            ...|.:       :.|:..|.|:..|    ..:.::|.:::.:|||..:|||:|.|        |
  Fly   336 QWVDYMNALLPEGLNVAEDEMINLSV----PSFFEDLGKLLAKTPKRVIANYMFWRIHGFSVGFL 396

  Fly   339 IWEFIQKP-------SGVAEKPT--EACVDFTKTYFAK-----------NLDNMIYRRYKNEKSS 383
            ..||.::.       ||..|:..  :.|||...:...:           ::.::...::.::.|.
  Fly   397 SEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGISVGSLYVGKHFHKDSK 461

  Fly   384 REIDSMWHQLKSTFKETLLSSPALDWIEPSTRSLAIAKLEAMTLEVN-------------NYVK- 434
            .....|.:::::.|.:.|   ..::|::..|:..|..||.:|...:.             .|.|
  Fly   462 ANALEMVNEIRNVFNDIL---DEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYAKL 523

  Fly   435 ----ENFTEEFADLNLQNTDCVENLRQVQMLQAKQMRQLYHQPAKPLEAGELLSYTPSNILLENS 495
                :.:.|.|..:|:..||...|..::.:.:...:|.     |:|.......|      .||||
  Fly   524 DIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRH-----ARPAIVNAFYS------SLENS 577

  Fly   496 IKVPVALLQPFYIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFL 560
            |:.|..:||. :.::...|..:.||.:.|:||||:.|||||.||:||.|||.:|||...:...:|
  Fly   578 IQFPAGILQG-HFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYL 641

  Fly   561 KRRDCFTKQYGRYV--YDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKE 623
            .:..|..:|||.|.  ..|:.|.....|.||||||||::.:|.|||:|.|.     :|.:    .
  Fly   642 AKAKCIIEQYGNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEK-----HGPE----A 697

  Fly   624 TLPNLRYTAKQLFFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAG 688
            .||.|.||.:|:|:::..|:||.....:...::::|..|.|.:|||:|:|||.::|:|:|:|..|
  Fly   698 KLPGLDYTPEQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEG 762

  Fly   689 SAMNPIEKC 697
            |.|||::||
  Fly   763 SPMNPVQKC 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	192/711 (27%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	194/711 (27%)
Nep2	NP_001246914.1	M13	104..772	CDD:189000	196/713 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920