DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl20 and KEL

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_005250050.1	Gene:	KEL / 3792	HGNCID:	6308	Length:	744	Species:	Homo sapiens

Alignment Length:	715	Identity:	166/715 - (23%)
Similarity:	280/715 - (39%)	Gaps:	143/715 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 NQKVDPCKDFYAFSCGNYKRINSALNMRVLTTGVFETLTKGLN--RKILKMLNTPHDSHDTPEDI 115
            |..|.||.||::|:||..|..|::..         |..||..|  |:||::.|:.|......:..
Human   106 NTSVAPCTDFFSFACGRAKETNNSFQ---------ELATKNKNRLRRILEVQNSWHPGSGEEKAF 161

  Fly   116 QVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQEDDFDWLNTTAR-MAHRYGIMSI 179
            |   ||.||:....:.:..:..|:::|.|.|...:  ...|...:|   |.|.| :..:||....
Human   162 Q---FYNSCMDTLAIEAAGTGPLRQVIEELGGWRI--SGKWTSLNF---NRTLRLLMSQYGHFPF 218

  Fly   180 IGVGVATDFANNQKNIIYINQQEF--PLKTRSMYMDNETAIYRQNYQNNIQLILEKYLGVKDELA 242
            ....:....|:....:|.|:|.||  |||     .|.|..||.|        |..:||...::|.
Human   219 FRAYLGPHPASPHTPVIQIDQPEFDVPLK-----QDQEQKIYAQ--------IFREYLTYLNQLG 270

  Fly   243 R------KAAKEMFEFEVDLAHGLVDNNKHLNLR----DLIELLTVAELRERYAPTLD---TDQL 294
            .      ...:|.....:.:...|....:.|..|    .|.:::|:.:|:| .||.:|   ..|.
Human   271 TLLGGDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKE-MAPAIDWLSCLQA 334

  Fly   295 IFVSMGEKISDKVYEYNRRYQQNLVEVIER---TPKSTVANYLFLRLI----------------- 339
            .|..|....|..:..::..|.:|:.:::|.   ..:..:.:::.|.|:
Human   335 TFTPMSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRK 399

  Fly   340 -----WEFIQKPSGVAEKPTEACVDFTKTYFAKNLDNMIYRRYKNEKSSREIDSMWHQLKSTFKE 399
                 .|..::|...|......||:.|.|:|...|..:..|    |.......|...:|.:..::
Human   400 LSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVR----EAFGPSTRSAAMKLFTAIRD 460

  Fly   400 TLLSS-PALDWIEPSTRSLAIAKLEAMTLEVN----NYVKENFTEEFADLNLQNT------DCVE 453
            .|::. ..|.|:...|:::|..|:..:.:|:.    ....|...:|:.|:.|.::      .||.
Human   461 ALITRLRNLPWMNEETQNMAQDKVAQLQVEMGASEWALKPELARQEYNDIQLGSSFLQSVLSCVR 525

  Fly   454 NLRQVQMLQAKQMRQLYHQPAKPLEAGELLSYTPSNILLENSIKVPVALLQPFYIWSDVYPNAVM 518
            :||...:....|....:.....|.:.....|.:      ::.:..|..||||.: :...||.||.
Human   526 SLRARIVQSFLQPHPQHRWKVSPWDVNAYYSVS------DHVVVFPAGLLQPPF-FHPGYPRAVN 583

  Fly   519 FGTLAYLIGHELIHGF------------DDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYG 571
            ||....::.|||:|.|            |:...:                    :...|..:.|.
Human   584 FGAAGSIMAHELLHIFYQLLLPGGCLACDNHALQ--------------------EAHLCLKRHYA 628

  Fly   572 RY-VYDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQL 635
            .: :.......:|....||.||.||:.:|..||.|    :|...:|     :..||:|..:.:|:
Human   629 AFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSK----RLLRHHG-----ETVLPSLDLSPQQI 684

  Fly   636 FFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKCILY 700
            ||.|:||..|....|     |.|.|.|.|...||.|.||:...|::.|.|..|:.:||..:|.|:
Human   685 FFRSYAQVMCRKPSP-----QDSHDTHSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW 744

Fly 701 700
Human 745 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	162/704 (23%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	163/707 (23%)
KEL	XP_005250050.1	PepO	106..744	CDD:226118	165/713 (23%)
KEL	XP_005250050.1	M13	109..742	CDD:189000	163/708 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151005
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6404
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.760