DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl20 and Nepl9

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_609815.1	Gene:	Nepl9 / 35020	FlyBaseID:	FBgn0032613	Length:	652	Species:	Drosophila melanogaster

Alignment Length:	782	Identity:	154/782 - (19%)
Similarity:	277/782 - (35%)	Gaps:	231/782 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WIASHVLSVL--VLAAPTSEDVLNQDTPYMKELMRQAKAAEIESFM------------NQKVDPC 59
            |....||..:  ::.:...||   .|:....|:..:.::.:..|.:            |..:|||
  Fly     3 WKLQFVLFAIIQIVRSQNGED---SDSDTEVEMDSEVESGQFFSHLYKSNLQQLVKIKNDSMDPC 64

  Fly    60 KDFYAFSCGNY---KRINS-------------ALNMRVLTTGVFETLTKGLNRKILKMLNTPHDS 108
            .||||.:|||:   |..||             .:|......|.|||:...|
  Fly    65 DDFYAHACGNFDQTKEENSDDFLPPYLYNKQDRMNFFTAEVGNFETIPGRL-------------- 115

  Fly   109 HDTPEDIQVKHFYESCLQIKELNSTYSEKL----KRLIAE----------FGTMPLLEGSSWQE- 158
                    :...|..|.:.:|.|.....:|    :|::.|          ..:.|.|: ..|:.
  Fly   116 --------ISQLYTECRKREERNVFTPTRLTSHWERMLDEIPFLARHKEVLSSWPFLK-HQWERR 171

  Fly   159 ---DDFDWLNTTARMAHRYGIMSIIGVGVATDFANNQKNIIYIN-QQEFPLKTRSMYMDNETAIY 219
               ...:|:..:|::| .:|:.:::.:..|.|       .||:: .:|.|..:.:
  Fly   172 RLYGQLNWIVLSAQLA-AHGLPTLLHIYFALD-------TIYVSPMEELPCPSIA---------- 218

  Fly   220 RQNYQNNIQLILEKYLGVKDELARKAAKEM------FEFEVDLAHGLVDNNKHLNLRDLIELLTV 278
              ::|:::..:||   |...:::|..:.||      ...|:.|...|..|.:....|...|.|.:
  Fly   219 --DFQSSLSDVLE---GRHHQVSRIISHEMRVLCREMRGELPLVRSLSQNTRTNTSRPGEEQLLL 278

  Fly   279 AELRERYAPTLDTDQLIFVSMGEKISDKVYEYNRRYQQNLV------EVIERTPKSTVANYLFLR 337
            .|      .|:|..|..|.::  ..|::.....|::..::.      ||:..|....|.||
  Fly   279 DE------NTMDYFQQYFAAL--NFSEERLVGARKFPLDVEKITQAWEVLRHTETRIVYNY---- 331

  Fly   338 LIW---EFIQKPS--GVAEKPTEACVDFTKTYFAKNLDNMIYRRYKNEKSSREIDSMWHQLKSTF 397
            ::|   |.::.|.  .|:|       :|.:...|:.....:.||:    .|||:....:||.:|.
  Fly   332 VMWQAREQLRYPDCYRVSE-------EFERLLHAEYWQWHVLRRH----LSREVALASYQLHTTR 385

  Fly   398 KETLLSS--PALDW---IEPST---RSLAIAKLEAMTLEVNNYVKENFT---EEFADLNLQNTDC 451
            .:.|..|  ...||   :.|::   :.|.:|::  :.....||:  |.|   |.:..|.|:....
  Fly   386 FQKLRRSKLSRRDWYGHLWPASVEKKELQVARI--LQNHAENYL--NITELNENYEGLKLEKNSF 446

  Fly   452 VENLRQVQMLQAKQMRQLYHQPAKPLEAGELLSYTPSNILLENSIKVPVALLQPF--YIWSDVY- 513
            ..||   .:|:..|:|..:..|           |..     |..:..|...|:.|  ::...::
  Fly   447 YANL---LILRRAQLRHSFVSP-----------YVD-----EEDVNQPAYFLRHFLHFVLLSLHR 492

  Fly   514 PNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEK----SSSNFLKRRDCFTKQYGRYV 574
            |....:.|          ||.              :.|.|.    .:.......||..:|..::
  Fly   493 PTYHYYAT----------HGL--------------ELWRESRLLLDTDGHYTAMDCLERQSFQH- 532

  Fly   575 YDG-IQLKESTAQSENIAD----NGGMRLAYTAYRKWYENQLTLPNGAQDMTKET--LPNLRYTA 632
            ||. :........|..||:    ....:.:.|.|..|.:       |.:....||  |.......
  Fly   533 YDAKLAPIYRPLGSHEIAEIFQFYRSFQYSLTDYHFWLQ-------GERFAFAETFVLDYFGLNP 590

  Fly   633 KQLFFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKC 697
            .::.|.:.||..||. ..::.|.|::..            ..|..||.:.|.|.|..||||..:|
  Fly   591 HRVLFYAVAQQLCNR-QTEIFAAQLNRG------------YMNLPEFQEAFKCGAEKAMNPPSRC 642

  Fly   698 IL 699
            ::
  Fly   643 MI 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	142/729 (19%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	144/717 (20%)
Nepl9	NP_609815.1	GluZincin	62..>84	CDD:301352	12/21 (57%)
Nepl9	NP_609815.1	GluZincin	<579..642	CDD:301352	20/75 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454973
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.930