DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl20 and Nep3

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001245775.1	Gene:	Nep3 / 33005	FlyBaseID:	FBgn0031081	Length:	786	Species:	Drosophila melanogaster

Alignment Length:	777	Identity:	220/777 - (28%)
Similarity:	342/777 - (44%)	Gaps:	134/777 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTMKLFCIWI-----------ASHVLSVLVLAAPTSEDVLNQDTPYMKELMRQAK-----AAEIE 49
            |.:.:|.:.|           ..|||.|         ....:|.|...||....|     ::||.
  Fly    61 MAITIFTLLIVLFTDGGSSDATKHVLHV---------QPHQKDCPSGNELPCLNKHCIFASSEIL 116

  Fly    50 SFMNQKVDPCKDFYAFSCGNYKRINSALNMRVLTTGVFETLTKGLNRKILK-MLNTPHDSHDTPE 113
            ..::..||||.|||.:||..:.: |:.:.....|.|.|..|.: :|:.|:: :|..|..|..:..
  Fly   117 KSIDVTVDPCDDFYGYSCNQWIK-NNPIPEGKSTWGTFGKLEQ-MNQLIIRNVLEKPAKSFKSDA 179

  Fly   114 DIQVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMP----LLEGSSWQ-----EDDFDW-LNTTA 168
            :.:.|.:|||||...|    :.|||       |..|    ||:...|.     .:..:| :..|.
  Fly   180 ERKAKVYYESCLDADE----HMEKL-------GAKPMNDLLLQIGGWNVTKSGYNVANWTMGHTL 233

  Fly   169 RMAH-RYGIMSIIGVGVATDFANNQKNIIYINQQEFPLKTRSMYMDNETAIYRQNYQNNIQLILE 232
            ::.| :|....:.|..:..|..|:.:::|.|:|....|         .||.|..|..:|.:.:|.
  Fly   234 KILHNKYNFNCLFGWAIGEDDKNSSRHVIQIDQGGLTL---------PTADYYNNKTDNHRKVLN 289

  Fly   233 KY----------LGVKDELARKAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRERYAP 287
            :|          ||..:..||.....:..||..||:..:......|...:...:.:.:| .:.||
  Fly   290 EYIEYMTKVCVLLGANESDARAQMIGVINFEKKLANITIPLEDRRNEEAMYHPMQLRQL-SKLAP 353

  Fly   288 TLD-TDQL--IFVSMGEKISDK--VYEYNRRYQQNLVEVI---ERTP--KSTVANYLFLRLIWEF 342
            .|: ||..  ....:|.:::|.  |..|...:.:||.::|   |:|.  |.|:.||    |:|:.
  Fly   354 FLNWTDHFDNAMQMVGRRVTDDEVVVVYAPDFLKNLSDIILKMEQTEEGKITLNNY----LVWQA 414

  Fly   343 IQKPSGVAEKP---------------------TEACVDFTKTYFAKNLDNMIYRRYKNEKSSREI 386
            ::..:....||                     ...||..|.......:..:..|:..:.:|....
  Fly   415 VRTLTSCLSKPFRDAYKGVRKALMGSDGGEEIWRYCVSDTNNVVGFAVGAIFVRQAFHGESKPAA 479

  Fly   387 DSMWHQLKSTFKETLLSSPALDWIEPSTRSLAIAKLEAMT--LEVNNYVKE--NFTEEFADLNLQ 447
            :.|..:::..||..|.:   |.|::..||..||.|...::  :...:|:.:  ...:::|:||:.
  Fly   480 EQMIAEIREAFKMNLQN---LTWVDKQTREKAIEKANQISDMIGFPDYILDPVELDKKYAELNIT 541

  Fly   448 NTDCVENLRQVQMLQAKQMRQLYHQPAKPLEAGEL-----LSYTPSNILLENSIKVPVALLQ-PF 506
            .....||..||.:...|...:...||......|..     ..|||:    :|.|..|..:|| ||
  Fly   542 PNAYFENNIQVAIYNLKSNLKRLDQPVNKTNWGMTPQTVNAYYTPT----KNQIVFPAGILQTPF 602

  Fly   507 YIWSDV-YPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQY 570
            :   |: .|.::.||.:..::||||.|.|||.||::|:.||...|||.||...|.::.:|..:||
  Fly   603 F---DINNPKSLNFGAMGVVMGHELTHAFDDQGREYDKFGNINRWWDSKSIERFNEKSECIARQY 664

  Fly   571 GRYVYDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQL 635
            ..|..:|..|.......||||||||::.||.||      |.|..:...|:.|  ||.|..|..||
  Fly   665 SGYKMNGRTLNGKQTLGENIADNGGLKAAYHAY------QRTKSDRDVDILK--LPGLNLTHSQL 721

  Fly   636 FFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKC 697
            ||:||||.||:....:...||:..|.|.|.:|||||||||.:||::.|.|..|..|||.|||
  Fly   722 FFVSFAQVWCSSTTDETNLLQMEKDPHSPSQFRVIGTLSNMKEFAEVFQCKPGKRMNPTEKC 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	200/704 (28%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	204/704 (29%)
Nep3	NP_001245775.1	M13	123..784	CDD:189000	206/706 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451258
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850