DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl20 and goe

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001285350.1	Gene:	goe / 32660	FlyBaseID:	FBgn0027528	Length:	879	Species:	Drosophila melanogaster

Alignment Length:	800	Identity:	158/800 - (19%)
Similarity:	297/800 - (37%)	Gaps:	177/800 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CIWIASHVLSVLVLA----------APTSEDVLNQDTPYMKELMRQAKAAEIESFMNQKVDPCKD 61
            |:.....::.:|:||          ||...|         ||.:..::  ::..:.|....||.:
  Fly   135 CLCALLLLIIILLLAFWPEVPFYLRAPLCLD---------KECVESSR--QLLLWANTSKSPCHE 188

  Fly    62 FYAFSCGNYKRINSALNMRVLTTGV--FETLTK-----GLNRKILKMLNTPHDSHDTPEDIQVKH 119
            .|.::|||:....:.....|:..|.  :||..:     .|||.|..:.|:...|.::    .|..
  Fly   189 TYEWACGNFASDYANHEYFVIKRGEWNYETYNEYQELNELNRFIAMLPNSQEGSVES----TVSS 249

  Fly   120 FYESCLQIKELNSTYSE-KLKRLI-AEFGTMPLLEGSSWQEDDFDWLNTTARMAHRYGIMSIIGV 182
            .|.||.:...|:.:.|: .|||.| |.:|.....:.:..|  .:::......:..::||.....|
  Fly   250 LYRSCRETDVLDKSQSDLLLKRAINAVYGWQAFRDSNRLQ--SWEYKRVLVVLQAKHGIFPYYRV 312

  Fly   183 GVATDFANNQKNIIYINQQEFPLKTRSMY-MDNETAIYRQNYQNNIQLILEKY---LGVKDELAR 243
            .|...|:|....:|.:::.|..|..:..| .|.:..:.|     ..:|:|..:   :|:....|.
  Fly   313 TVENGFSNPHDYVITLDEGELGLPDKYFYGNDADEEVVR-----GYKLLLRDFAINMGIVSREAD 372

  Fly   244 KAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRER--YAPTLDTDQLIFVSMGEKISD- 305
            ..|.::|.:|..:.:.:.|.....| |.:.:|:.:|:|:.:  ..|.|::.|.||..  .||::
  Fly   373 LFADDIFHYERRIVNHIEDAKADAN-RPINKLMRLADLKIKAPSLPILESLQAIFPK--TKITED 434

  Fly   306 -KVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLIWEFIQKPSGVAEKPTEACVDFTKTY--FAK 367
             :|...:......|..::..:.|..:.|:    ::|...:|          .....:|.|  .|:
  Fly   435 TEVLVRDPEVMHALSVLLSTSDKKPINNF----IVWSLARK----------MLPHLSKEYRTLAE 485

  Fly   368 NLDNMIYRR--------------------------------------------YKNEKSSREIDS 388
            ..|:.:|.|                                            .|.:.:...:..
  Fly   486 TFDHALYGRTASYPRWLICSKVVRDWLPFAVDALQQQPPRQQFETMTSKSRGLNKTQGNEELLKL 550

  Fly   389 MWHQLKSTFKETLLSSPALDWIEPSTRSLAIAKLEAMTLEVN---------NYVKENFTEEFADL 444
            |:..|::..|::|..:   .|:||:.|.....||..|.|:..         .|:.:.:.|    |
  Fly   551 MFFSLRNQLKDSLEQA---KWLEPAARQFIQKKLNEMRLQFGIPDEVLQQPTYLAQYYNE----L 608

  Fly   445 NLQNTDCVENLRQVQMLQAKQMRQLYHQPAKPLEAGELL---SYT---PSNILLENSIKV----P 499
            .|.|...||:|..:...:..||    .:...||...:::   .||   |..|...|.:.:    .
  Fly   609 ILNNVFFVEHLEWIWTFRRSQM----EKKLGPLAILDVIVSEMYTRDNPQAIAYSNKLNMLLVSK 669

  Fly   500 VALLQPFYIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRR- 563
            |.:...:|.:.  ||.||.|..:...|...||..|.....:|:.:  |.|..|......:.:..
  Fly   670 VLISSNYYDYR--YPVAVNFARIGTDILEALIDNFSTFLLQFNTQ--STDISDAAPEIRYAQPDV 730

  Fly   564 DCFTK-QYGRYVYDGIQLKESTAQSENIADNGGMRLAYTAYRKW--YENQLTLPNGAQDM----- 620
            :|... |..|.|::..:|..:..:|.::.    :..|.||.|..  :.|.:...:..|..
  Fly   731 NCLAAGQPPRLVHELNELSSNALKSFHVT----LSAARTAARALSNFVNAIDAGSAIQGSGIDQA 791

  Fly   621 -TKETL--------PNLR-YTAKQLFFISFAQSWCNDV-----HPKVKALQVSTDDHMPGKFRVI 670
             |.|.|        |.|| :...:||.:|:.|..|:..     :.::|.|   .:..:...:...
  Fly   792 NTYEALGLTRRLRIPGLRSFNENELFTLSYMQQHCSTTIADKDYARIKPL---VESQLAESYLFN 853

  Fly   671 GTLSNFEEFSKEFNCHAGSA 690
            .|..:.:...:..||.|..|
  Fly   854 ATWQHIQFLPRSTNCAAAEA 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	148/746 (20%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	147/740 (20%)
goe	NP_001285350.1	GluZincin	184..>694	CDD:301352	110/550 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454915
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840