Protein Alignment Nepl20 and Mmel1

DIOPT Version :10

• Sequence 1: NP_651645.1
• Gene: Nepl20 / 43412
• FlyBaseID: FBgn0039613
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001101467.2
• Gene: Mmel1 / 313755
• RGDID: 1309299
• Length: 774
• Species: Rattus norvegicus
• Alignment Length: 717
• Identity: 192/717 - (26%)
• Similarity: 332/717 - (46%)
• Gaps: 97/717 - (13%)

  Fly    45 AAEIESFMNQKVDPCKDFYAFSCGNYKR------INSALNMRVLTTGVFETLTKGLNRKILKMLN 103
            ||.|...|:|...||.:||.::||.:.|      .||..::..:.....|.:.||    :|:..:
  Rat    94 AARILQNMDQSKKPCDNFYQYACGGWLRHHVIPETNSRYSVFDILRDELEVILKG----VLEDSS 154

  Fly   104 TPHDSHDTPEDIQVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPL-------LEGSSWQ-EDD 160
            ..|    .|...:.|..|.||:....:....||.|..::...|..|:       ..|..|: |..
  Rat   155 VQH----RPAVEKAKTLYRSCMNQSVIEKRDSEPLLNVLDMIGGWPVAMDKWNETMGPKWELERQ 215

  Fly   161 FDWLNTTARMAHRYGIMSIIGVGVATDFANNQKNIIYINQQEFPLKTRSMYMDNETAIYRQNY-- 223
            ...||:      ::....:|.:.:..|..|:.:::|||:|....:.:|..|...::...|:.|
  Rat   216 LAVLNS------QFNRRVLIDLFIWNDDQNSSRHVIYIDQPTLGMPSREYYFKEDSHRVREAYLQ 274

  Fly   224 -QNNIQLILEKYLGVKDE--LARKAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRERY 285
             ..::..:|.:.|.:..|  |.::...::...|..||:..|...|..::..|...:.:.||:||:
  Rat   275 FMTSVATMLRRDLNLPGETDLVQEEMAQVLHLETHLANATVPQEKRHDVTALYHRMGLEELQERF 339

  Fly   286 AP-----TLDTDQLIFVSMGEKI-SDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLIWEFIQ 344
            ..     ||....::.....|.: :::|..|...|.:||.|:|:..|..|:.|||..||:   :.
  Rat   340 GLKGFNWTLFIQNVLSSVQVELLPNEEVVVYGIPYLENLEEIIDVFPAQTLQNYLVWRLV---LD 401

  Fly   345 KPSGVAEKPTEACVDFTKTYFAKNLDNMIYRR---YKNEKSSREIDSMW---------------- 390
            :...::::..||.||:.|..:...::.:.:|.   |.|......:.|::
  Rat   402 RIGSLSQRFKEARVDYRKALYGTTMEEVRWRECVSYVNSNMESAVGSLYIKRAFSKDSKSIVSEL 466

  Fly   391 -HQLKSTFKETLLSSPALDWIEPSTRSLAIAKLEAMTLEVN--NYVKE----NFTEEFA------ 442
             .:::|.|.:.|   ..|:|::..::..|..|...:..::.  :|:.|    :..||::
  Rat   467 IEKIRSVFVDNL---DELNWMDEESKKKAQEKALNIREQIGYPDYILEDNNRHLDEEYSSLTFSE 528

  Fly   443 DLNLQNTDCVENLRQVQMLQAKQMRQLYHQPAKPLEAGELLS-YTPSNILLENSIKVPVALLQPF 506
            ||..:|.  ::||:.......|::|:...|....:.|..:.: |:|:    .|.|..|..:|||.
  Rat   529 DLYFENG--LQNLKNNAQRSLKKLREKVDQNLWIIGAAVVNAFYSPN----RNLIVFPAGILQPP 587

  Fly   507 YIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYG 571
            :...| .|.|:.||.:..:||||:.|||||:||.||:.||..|||...|:.:|.::..|...||.
  Rat   588 FFSKD-QPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMLDWWSNFSARHFRQQSQCMIYQYS 651

  Fly   572 RYVY---DGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAK 633
            .:.:   |...:...:...||||||||:|.||.||.:|      |..|.:|   :.||.|..|..
  Rat   652 NFSWELADNQNVNGFSTLGENIADNGGVRQAYKAYLQW------LAEGGRD---QRLPGLNLTYA 707

  Fly   634 QLFFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKCI 698
            |||||::||.||....|:.....:.||.|.|.|:||:|:|.|...||:.|:|..||.|:|:.:|.
  Rat   708 QLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLPGFSEAFHCPRGSPMHPMNRCR 772

  Fly   699 LY 700
            ::
  Rat   773 IW 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	M13	56..697	CDD:341056	186/701 (27%)
Mmel1	NP_001101467.2	Stop-transfer sequence. /evidence=ECO:0000255	14..21
		M13	106..772	CDD:341056	186/701 (27%)