DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl20 and Phex

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_037136.2	Gene:	Phex / 25512	RGDID:	3323	Length:	749	Species:	Rattus norvegicus

Alignment Length:	727	Identity:	190/727 - (26%)
Similarity:	314/727 - (43%)	Gaps:	111/727 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 AAEIESFMNQKVDPCKDFYAFSCGNYKRINSALNMRVLTTGVFETLTKGLNRKILKMLNTPHDSH 109
            ||.|.|.:|..||||::|:.|:|..:.. |:.:...:.:.||:..|...::.|:..:|.......
  Rat    63 AAAIMSKVNLSVDPCENFFRFACDGWIS-NNPIPEDMPSYGVYPWLRHNVDLKLKALLEKSVSRR 126

  Fly   110 DTPEDIQ-VKHFYESCLQIKELNSTYSEKLKRLI--AEFGTMPLLEGS-----SWQEDDFDWLNT 166
            ...|.:| .|..|.||:..|.:....::.|..::  :.| ..|:||.:     .|.|..|..|.|
  Rat   127 RDTEAVQKAKILYSSCMNEKAIEKADAKPLLHILRHSPF-RWPVLEANIGPEGVWSERKFSLLQT 190

  Fly   167 TARMAHRYGIMSIIGVGVATDFANNQKNIIYINQQEFPLKTRSMYMDNET-------AIYRQNYQ 224
            .|....:|.....|.:.|:.|...:.::|:.::|....|..|..::||.|       |:|:....
  Rat   191 LATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDFLDNTTEAKSYRDALYKFMVD 255

  Fly   225 NNIQLILEKYLGVKDELARKAAKEMFEFEVDLAHGLVDN---------NKHLNLRDLIELLTVAE 280
            ..:      .||.....|....|.:...|:.:|..::.:         || :|:.:|..::...:
  Rat   256 TAV------LLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNK-MNISELSAMIPQFD 313

  Fly   281 LRERYAPTLDT---DQLIFVSMGEKISDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLIW-- 340
            ........:||   ..|..:...|.:..:|.:|.:    :|..::....|.|:||||..|:::
  Rat   314 WLGYIKKVIDTRLYPHLKDIGPSENVVVRVPQYFK----DLFRILGAERKKTIANYLVWRMVYSR 374

  Fly   341 -------------EFIQKPSGVAEKPT------EACVDFTKT----YFAKNLDNMIYRRYKNEKS 382
                         ||    |.|.:..|      :.||:|.::    ...|...|:.::..|.|..
  Rat   375 IPNLSRRFQYRWLEF----SRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVNVHFQEDKKEMM 435

  Fly   383 SREIDSM-WHQLKSTFKETLLSSPALDWIEPSTRSLAIAKLEAMTLEV--------NNYVKENFT 438
            ...|:.: |..:....||.       :|::..|:..|..|..|:..:|        :.||    .
  Rat   436 EELIEGVRWAFIDMLEKEN-------EWMDAGTKRKAQEKARAVLAKVGYPEFIMNDTYV----N 489

  Fly   439 EEFADLNLQNTDCVENLRQVQMLQAKQ----MRQLYHQP---AKPLEAGELLSYTPSNILLENSI 496
            |:...:....:|...|:.|.:...|:.    :|:...:.   ..|......  |:.|.    |.|
  Rat   490 EDLKAIKFSESDYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAF--YSAST----NQI 548

  Fly   497 KVPVALLQPFYIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLK 561
            :.|...||..:.|...||.::.:|.:..::|||..||||::|||:|:.||...||...|...|.:
  Rat   549 RFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSVDSEEKFKE 613

  Fly   562 RRDCFTKQYGRYVYD--GIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKET 624
            :..|...||..|.:.  |:.:|......||||||||:|.|:.|||||..::      .|.:.:..
  Rat   614 KTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDR------RQGVEEPL 672

  Fly   625 LPNLRYTAKQLFFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGS 689
            ||.:.:|..||||:|:|...||...|:....||....|.|.:|||.|.:||||||.|.|||.|.|
  Rat   673 LPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPANS 737

  Fly   690 AMN-PIEKCILY 700
            .|| ..:.|.|:
  Rat   738 TMNRGADSCRLW 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	183/710 (26%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	183/711 (26%)
Phex	NP_037136.2	M13	74..740	CDD:341056	181/705 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920