DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl20 and Mme

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_036740.1	Gene:	Mme / 24590	RGDID:	3098	Length:	750	Species:	Rattus norvegicus

Alignment Length:	773	Identity:	195/773 - (25%)
Similarity:	339/773 - (43%)	Gaps:	146/773 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LSVLVLAA-----------PTSEDVLNQDTPYMKELMRQAKAAEIESFMNQKVDPCKDFYAFSCG 68
            ||||||..           .|.:|.:.:.:..:|      .||.:...|:...:||.||:.::||
  Rat    31 LSVLVLLLTIIAVTMIALYATYDDGICKSSDCIK------SAARLIQNMDASAEPCTDFFKYACG 89

  Fly    69 NYKRINSALNMRVLTTGVFETLTKGLNRKILK---------MLNTPHDSHDTPEDI----QVKHF 120
            .:.:.|.          :.||.::..|..||:         :|..|     ..|||    :.|..
  Rat    90 GWLKRNV----------IPETSSRYSNFDILRDELEVILKDVLQEP-----KTEDIVAVQKAKTL 139

  Fly   121 YESCLQIKELNSTYSEKLKRLIAEFGTMPLLE-------GSSWQEDDFDWLNTTARMAHRYGIMS 178
            |.||:....::|...:.|..|:.:....|:..       |:||..:     .:.|::..:||...
  Rat   140 YRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGTSWTAE-----KSIAQLNSKYGKKV 199

  Fly   179 IIGVGVATDFANNQKNIIYINQQEFPLKTRSMYMDNETAIYRQNYQNNIQLIL--------EKYL 235
            :|...|.||..|:.::||:.:|....|.:|..|  ..|.||::.....:..::        |:.|
  Rat   200 LINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYY--ECTGIYKEACTAYVDFMISVARLIRQEQRL 262

  Fly   236 GVKDELARKAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRERYAPTLD---------T 291
            .:.:........::.|.|.::|:.........:...|...:|:|:|:..::..::         |
  Rat   263 PIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEINGKPFSWSNFT 327

  Fly   292 DQLI-FVSMGEKISDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLIWEFIQKPSGVAEKPTE 355
            :::: .|::..:..::|..|...|...|..::.:.....:.|.:..|.|.:.:   |.::....|
  Rat   328 NEIMSTVNINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLV---SSLSRNYKE 389

  Fly   356 ACVDFTK----------------TYFAKNLDNMIYRRYKNE----KSSREIDSMWHQLKSTFKET 400
            :...|.|                .|...|::|.:.|.|...    :|...::.:..|::..|.:|
  Rat   390 SRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQT 454

  Fly   401 LLSSPALDWIEPSTRSLAIAKLEAMTLEVNNYV--------KEN-FTEEFADLNLQNTDCVENLR 456
            |   ..|.|::..|:.    |.|...|.:...:        .|| ...|:.:||.:..:..||:.
  Rat   455 L---DDLTWMDAETKK----KAEEKALAIKERIGYPDDIISNENKLNNEYLELNYKEEEYFENII 512

  Fly   457 Q-VQMLQAKQMRQLYHQPAKPLEAGELLS--------YTPSNILLENSIKVPVALLQPFYIWSDV 512
            | ::..|:||:::|    .:.::..|.:|        |:..    .|.|..|..:|||.: :|..
  Rat   513 QNLKFSQSKQLKKL----REKVDKDEWISGAAVVNAFYSSG----RNQIVFPAGILQPPF-FSAR 568

  Fly   513 YPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYD- 576
            ..|::.:|.:..:||||:.|||||:||.|::.|:..|||.::|::||..:..|...|||.:.:|
  Rat   569 QSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDL 633

  Fly   577 --GIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFIS 639
              |..|.......||||||||:..||.||:.:.:.     ||.:.:    ||.|....|||||::
  Rat   634 AGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKK-----NGEEKL----LPGLDLNHKQLFFLN 689

  Fly   640 FAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKC 697
            |||.||....|:.....:.||.|.||.||:||||.|..||:..|:|...|.|||..||
  Rat   690 FAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKC 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	179/719 (25%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	181/719 (25%)
Mme	NP_036740.1	Stop-transfer sequence. /evidence=ECO:0000255	16..23
Mme	NP_036740.1	M13	79..748	CDD:341056	183/719 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344468
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950