DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl20 and Kel

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_115929.3	Gene:	Kel / 23925	MGIID:	1346053	Length:	713	Species:	Mus musculus

Alignment Length:	729	Identity:	180/729 - (24%)
Similarity:	297/729 - (40%)	Gaps:	134/729 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DTPYMKELMRQAKAAEIESFMNQKVDPCKDFYAFSCGNYKRINSALNMRVLTTGVFETLTKGLNR 96
            :||...||:....|:.     |:.|.||.||::|:|   ::.|.       |:..|:.||:....
Mouse    59 ETPVCMELLDHYLASG-----NRSVAPCTDFFSFAC---EKANG-------TSDSFQALTEENKS 108

  Fly    97 KILKMLNTPHDSHDTPEDIQVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQEDDF 161
            ::.::|..|...|....:.:...||.||:....:.::.|..|.::|.|.|...:.  .:|...||
Mouse   109 RLWRLLEAPGSWHLGSGEEKAFQFYNSCMDTDAIEASGSGPLIQIIEELGGWNIT--GNWTSLDF 171

  Fly   162 DWLNTTAR-MAHRYGIMSIIGVGVATDFANNQKNIIYINQQEFPLKTRSMYMDNETAIYRQ---- 221
               |...| :..:||........:....|.....||.|:|.||.:   .:..:.|..:|.|
Mouse   172 ---NQNLRLLMSQYGHFPFFRAYLRPHPAPPHTPIIQIDQPEFDI---LLQQEQEQKVYAQILRE 230

  Fly   222 --NYQNNIQLILEKYLGVKDELARKAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRER 284
              .|.|.:..:    ||...:.|::.|.....|...|...|....:......|..::|:.||:|
Mouse   231 YVTYLNRLGTL----LGSNPQEAQQHASWSIVFTSRLFQFLRPQQQQQAQDKLFHVVTIDELQE- 290

  Fly   285 YAPTLD---TDQLIFVSMGEKISDKVYEYNRRYQQNLVEVIER---TPKSTVANYLFLRLI---- 339
            .||.:|   ..|.||..|....|..:..::..|.:|:.:::|.   ..:.::.:|:.|.|:
Mouse   291 MAPAIDWLSCLQAIFTPMSLNSSQTLVVHDLDYLRNMSQLVEEGLLNHRESIQSYMILGLVDTLS 355

  Fly   340 -----------WEFIQKPSGVAEKPT-------EACVDFTKTYFAKNLDNMIYRRYKNEKSSREI 386
                       .|.||:...:.|:|.       ..||:.|..:|...|..:..|    |.....|
Mouse   356 PALDTKFQEARRELIQELRKLKERPPLPAYPRWMKCVEQTGAFFEPTLAALFVR----EAFGPSI 416

  Fly   387 DSMWHQLKSTFKE-TLLSSPALDWIEPSTRSLAIAKLEAMTLEV---NNYVKENF-TEEFADLNL 446
            .|...:|.:..|: .::....|.||...|:..|:.||..:.:|:   ...||.:. |:|:.|:.|
Mouse   417 QSAAMELFAEIKDAVIIRLKKLSWISEETQKEALNKLAQLQVEMGAPKRAVKPDIATQEYNDIQL 481

  Fly   447 QNTDCVENLRQVQMLQAKQMRQL-----YHQPAK-PLEAGELLSYTPSNILLENSIKVPVALLQP 505
            ..:.....|..|:.|:|:.::..     ||:..| |.|.....|      :.::.:..|..||||
Mouse   482 GPSFLQSFLSCVRSLRARNVQSFLQPFPYHRWQKSPWEVNAYYS------ISDHMVVFPAGLLQP 540

  Fly   506 FYIWSDVYPNAVMFGTLAYLIGHELIHGF------------DDSGRKFDEKGNSKDWWDEKSSSN 558
            .: :...||.||.||....::.|||:|.|            |                     ::
Mouse   541 PF-FHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCPACD---------------------TH 583

  Fly   559 FLKRR-DCFTKQYGRYVYDGI-QLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMT 621
            .|:.. .|..:.|..:....| ....|....||.||.||:.:|:.||.|    ::....|
Mouse   584 VLQEALLCLERHYAAFPLPSISSFNGSHTLLENAADIGGVAIAFQAYSK----RIVEHTG----- 639

  Fly   622 KETLPNLRYTAKQLFFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCH 686
            :.|||||..:..||||.|:||..|..:     :.|...|.|.|...||.|.|||..:|:|.|:|.
Mouse   640 ELTLPNLDLSPYQLFFRSYAQVMCRGL-----SSQDPQDPHSPPSLRVHGPLSNTPDFAKHFHCP 699

  Fly   687 AGSAMNPIEKCILY 700
            .|:.:||..:|.|:
Mouse   700 RGTLLNPSARCKLW 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	171/700 (24%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	172/700 (25%)
Kel	NP_115929.3	M13	78..711	CDD:341056	172/701 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841121
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6404
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.760