Protein Alignment Nepl20 and Ece1

DIOPT Version :10

• Sequence 1: NP_651645.1
• Gene: Nepl20 / 43412
• FlyBaseID: FBgn0039613
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001356106.1
• Gene: Ece1 / 230857
• MGIID: 1101357
• Length: 769
• Species: Mus musculus
• Alignment Length: 713
• Identity: 203/713 - (28%)
• Similarity: 316/713 - (44%)
• Gaps: 115/713 - (16%)

  Fly    46 AEIESFMNQKVDPCKDFYAFSCGNYKRINSALNMRVLTTGVFETLTKGLNRKILKML--NTPHDS 108
            :.|.:.|:..||||:||::::||.:.:.|...:.. ...|.|..|.:. |:.::|.|  |.....
Mouse   108 SSILNSMDPTVDPCQDFFSYACGGWIKANPVPDGH-SRWGTFSNLWEH-NQAVIKHLLENATASV 170

  Fly   109 HDTPEDIQVKHFYESCLQIKELNSTYSEKLKRLIAEFG----TMPLLEGSSWQEDDFDWLNTTAR 169
            .:.....||  :|.:|:....:....::.|..||.:.|    |.|      |.:|:|.  :|...
Mouse   171 SEAERKAQV--YYRACMNETRIEELRAKPLMELIEKLGGWNITGP------WAKDNFQ--DTLQV 225

  Fly   170 MAHRYGIMSIIGVGVATDFANNQKNIIYINQQEFPLKTRSMYM---DNETAIYRQNYQNNIQLIL 231
            :...|.......|.|:.|..|:..|:|.::|....|.:|..|:   :||..:  ..|. |..:.|
Mouse   226 VTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVL--TGYL-NYMVQL 287

  Fly   232 EKYLGVKDELA-RKAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRE-----RYAPTLD 290
            .|.||..||.| |...:::.:||..||:..:...|..:...:...:|.|||:.     .:.|.|:
Mouse   288 GKLLGGGDEDAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLN 352

  Fly   291 TDQLIFVSMGEKISDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLIWEFIQKPSGVAE---- 351
            |   ||..:....|:.:..|::.|.:.:..:|..|.|..:.||    ::|..::|.|...:
Mouse   353 T---IFYPVEINESEPIVVYDKEYLRQVSTLINNTDKCLLNNY----MMWNLVRKTSSFLDQRFQ 410

  Fly   352 -------------KPT-----EACVDFTKTYFAKNLDNMIYRRYKNEKSSREIDSMWHQLKSTFK 398
                         |.|     :.||..|:......|..|..:....|.|......:..::|..|:
Mouse   411 DADEKFMEVMYGTKKTCIPRWKFCVSDTENNLGFALGPMFVKATFAEDSKNIASEIIMEIKKAFE 475

  Fly   399 ETLLSSPALDWIEPSTRSLAIAKLEAM--TLEVNNYVKE--------NFTEEFADLNLQNT---- 449
            |:|   ..|.|::..||..|..|.:|:  .:...|::.:        |......||..:|.
Mouse   476 ESL---STLKWMDEETRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFF 537

  Fly   450 -----DCVENLRQV----QMLQAKQMRQLYHQPAKPLEAGELLSYTPSNILLENSIKVPVALLQ- 504
                 ...:.||:.    |......|...|:.|.|                  |.|..|..:||
Mouse   538 NFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTK------------------NEIVFPAGILQA 584

  Fly   505 PFYIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQ 569
            |||..|.  |||:.||.:..::||||.|.|||.||::|:.||.:.||...|...|.::.:|..:|
Mouse   585 PFYTRSS--PNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQ 647

  Fly   570 YGRYVYDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQ 634
            |..|..:|..:.......||||||||::.||.||:.|.:.     |||:    :|||.|..|:.|
Mouse   648 YSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKK-----NGAE----QTLPTLGLTSNQ 703

  Fly   635 LFFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKC 697
            |||:.|||.||:...|:.....:.||.|.|.:|||||:|||.:|||:.|.|..||.|||..||
Mouse   704 LFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPHHKC 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	M13	56..697	CDD:341056	199/701 (28%)
Ece1	NP_001356106.1	M13	118..767	CDD:341056	201/703 (29%)