DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl20 and ECE1

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_011539174.1	Gene:	ECE1 / 1889	HGNCID:	3146	Length:	778	Species:	Homo sapiens

Alignment Length:	713	Identity:	203/713 - (28%)
Similarity:	312/713 - (43%)	Gaps:	115/713 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 AEIESFMNQKVDPCKDFYAFSCGNYKRINSALNMRVLTTGVFETLTKGLNRKILKML--NTPHDS 108
            :.|.|.|:..||||.||::::||.:.:.|...:.. ...|.|..|.:. |:.|:|.|  |:....
Human   117 SSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGH-SRWGTFSNLWEH-NQAIIKHLLENSTASV 179

  Fly   109 HDTPEDIQVKHFYESCLQIKELNSTYSEKLKRLIAEFG----TMPLLEGSSWQEDDFDWLNTTAR 169
            .:.....||  :|.:|:....:....::.|..||...|    |.|      |.:|:|.  :|...
Human   180 SEAERKAQV--YYRACMNETRIEELRAKPLMELIERLGGWNITGP------WAKDNFQ--DTLQV 234

  Fly   170 MAHRYGIMSIIGVGVATDFANNQKNIIYINQQEFPLKTRSMYM---DNETAIYRQNYQNNIQLIL 231
            :...|.......|.|:.|..|:..|:|.::|....|.:|..|:   :||..:  ..|. |..:.|
Human   235 VTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVL--TGYL-NYMVQL 296

  Fly   232 EKYLGVKDELA-RKAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRE-----RYAPTLD 290
            .|.||..||.| |...:::.:||..||:..:...|..:...:...:|.|||:.     .:.|.|:
Human   297 GKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLN 361

  Fly   291 TDQLIFVSMGEKISDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLIWEFIQKPSGVAE---- 351
            |   ||..:....|:.:..|::.|.:.:..:|..|.:..:.||    :||..::|.|...:
Human   362 T---IFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNY----MIWNLVRKTSSFLDQRFQ 419

  Fly   352 -------------KPT-----EACVDFTKTYFAKNLDNMIYRRYKNEKSSREIDSMWHQLKSTFK 398
                         |.|     :.||..|:......|..|..:....|.|......:..::|..|:
Human   420 DADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFE 484

  Fly   399 ETLLSSPALDWIEPSTRSLAIAKLEAM--TLEVNNYVKE--------NFTEEFADLNLQNT---- 449
            |:|   ..|.|::..||..|..|.:|:  .:...|::.:        |......||..:|.
Human   485 ESL---STLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFF 546

  Fly   450 -----DCVENLRQV----QMLQAKQMRQLYHQPAKPLEAGELLSYTPSNILLENSIKVPVALLQ- 504
                 ...:.||:.    |......|...|:.|.|                  |.|..|..:||
Human   547 NFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTK------------------NEIVFPAGILQA 593

  Fly   505 PFYIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQ 569
            |||..|.  |.|:.||.:..::||||.|.|||.||::|:.||.:.||...|...|.::.:|..:|
Human   594 PFYTRSS--PKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQ 656

  Fly   570 YGRYVYDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQ 634
            |..|..:|..:.......||||||||::.||.||:.|.:.     |||:    .:||.|..|..|
Human   657 YSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKK-----NGAE----HSLPTLGLTNNQ 712

  Fly   635 LFFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKC 697
            |||:.|||.||:...|:.....:.||.|.|.:|||||:|||.:|||:.|.|..||.|||..||
Human   713 LFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKC 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	197/701 (28%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	198/701 (28%)
ECE1	XP_011539174.1	PepO	114..769	CDD:226118	198/705 (28%)
ECE1	XP_011539174.1	M13	127..776	CDD:189000	200/703 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150955
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850