DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl20 and nep-2

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_494343.2	Gene:	nep-2 / 188090	WormBaseID:	WBGene00020230	Length:	736	Species:	Caenorhabditis elegans

Alignment Length:	737	Identity:	206/737 - (27%)
Similarity:	327/737 - (44%)	Gaps:	149/737 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 AAEIESFMNQKVDPCKDFYAFSCGNYKR-------INSALNMRVLTTGVFETLTKGLNRKILKML 102
            |:.|.|.||..||||.|||.|:||.:.:       ..|..|        ||.|.:.|...:.::|
Worm    62 ASVILSSMNSSVDPCDDFYEFACGQWIKGHPIPDDAPSVSN--------FENLGQDLEFALKELL 118

  Fly   103 NTPHDSHDTPEDIQ------VKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQEDDF 161
                |.:|.|.|.:      .|:||..||...|:...:......::..||..|.|......:...
Worm   119 ----DENDEPYDYETSAVGKAKYFYNLCLNESEILDNWRTTFDEVVKSFGGWPSLGHQMKPDASI 179

  Fly   162 DWLNTTARMAHRYGIMSIIGVGVATDFANNQKNIIYINQQEFPLKTRSMYM--DNETAIYRQNYQ 224
            :.|  .|.|..::...|:....|..|..|:|::::.|:|.:..|..|..|:  :||.   |..|
Worm   180 EML--YADMVAKFKADSLFKATVQPDDKNSQRHVLLIDQPQLNLFARDFYVAAENEE---RMAY- 238

  Fly   225 NNIQLILEKYLGVKDELARKA--AKEMFEFEVDLAH-GLVDNNKHLNLRDLIELLTVAELRERYA 286
              :|||.:..:.:..:..|..  |||:.:||..||: .:.|.::| ::.:|...:|:.|:| |..
Worm   239 --LQLIRDVLILLDADRTRATLDAKEIIDFETALANITMADEHRH-DIAELYTKITLGEMR-RSL 299

  Fly   287 PTLDTDQLIFVSMGEKISDK------------VYEYNRRYQQNLVEVIERTPKSTVANYLFLRLI 339
            |..:. .|.|..|.:.:.:|            |..|...:.:.|..:|.:.....:.||  |...
Worm   300 PHFNW-PLFFNRMFKDLHEKNGKRITFDDNTEVVVYGYEFLRRLDVLIPQYDNRLIVNY--LEWC 361

  Fly   340 WEFIQKPSGVAEKPTEACVDFTKTYFAKNLDNM----------------------IY-RRYKNEK 381
            |.|   .:.:.:.|....:...|.|...|:.|:                      || :.:.:.:
Worm   362 WFF---KTMLRDLPDPFALTIFKFYKTLNIMNVQKVRWHGCVTRINSLMPMATSAIYVKNHFDHE 423

  Fly   382 SSREIDSMWHQLKSTFKETLLSSPALDWIEPSTRSLAIAKLEAMTLEV-------------NNY- 432
            :.::::.|...:..:|.:.|||.   ||:...|:..|..|:..|..::             |.|
Worm   424 AKQQVEEMISLIMESFVDLLLSE---DWLTKETKQTAKQKVNEMKRKIGYPDYLNDPAAVNNEYK 485

  Fly   433 -----------VKENFTEEF-ADLNLQNTDCVENLRQVQMLQAKQMRQLYHQPAKPLEAGELL-- 483
                       .|.:|.|:: .|:..:.|:.|:..|.|                    ||..|
Worm   486 TFKVYPGHYYQTKFSFYEQYQRDVLERITEAVDRERWV--------------------AGAALVN 530

  Fly   484 -SYTPSNILLENSIKVPVALLQPFYIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNS 547
             .|:|:.    |.|..|..:|||.: :|..:|:::.||.:..:||||:.|||||.||.:|..||.
Worm   531 AFYSPNT----NEIIFPAGILQPVF-YSKDFPSSMNFGGIGVVIGHEITHGFDDRGRLYDNLGNI 590

  Fly   548 KDWWDEKSSSNFLKRRDCFTKQYGRYVYDGI--QLKESTAQSENIADNGGMRLAYTAYRKWYENQ 610
            :.|||..:.|.|..:..|..|||..||.|.|  |:...:.:.||||||||::.||.||:| ||.:
Worm   591 RQWWDNATISKFEHKAQCIEKQYSSYVLDQINMQINGKSTKGENIADNGGLKQAYRAYKK-YEKR 654

  Fly   611 LTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSN 675
            .:.|        ..||.:..|..||||:::||.||..::.|....::.|.:|.||..||.|.|||
Worm   655 HSRP--------PRLPGVNLTHDQLFFLNYAQIWCGTMNDKEAIRKLRTSEHSPGPIRVKGPLSN 711

  Fly   676 FEEFSKEFNCHAGSAMNPIEKC 697
            ..:|:|.:||..||.|||.|||
Worm   712 SYDFAKAYNCEPGSQMNPREKC 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	198/724 (27%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	199/724 (27%)
nep-2	NP_494343.2	PepO	61..736	CDD:226118	206/737 (28%)
nep-2	NP_494343.2	M13	73..734	CDD:189000	201/726 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920