DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl20 and nep-18

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_494297.1	Gene:	nep-18 / 186911	WormBaseID:	WBGene00019343	Length:	701	Species:	Caenorhabditis elegans

Alignment Length:	763	Identity:	181/763 - (23%)
Similarity:	314/763 - (41%)	Gaps:	180/763 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DTPYMKELMRQAKAAEIESFMNQKVDPCKDFYAFSCGNYKR----INS--ALNMRVLTTGVFETL 90
            :|.:.||.:  ...|.|:::.|..||||:||:..:||.|..    .||  .:..:.|...||
Worm    25 ETCWSKECV--GVLAMIKNYQNASVDPCEDFFEHTCGRYSEHVMDDNSWGYVQYKQLLYQVF--- 84

  Fly    91 TKGLNRKILKMLNTPHDSHDTPEDIQVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSS 155
              .:.||..|..:.|::        |::.|.:|||..||::....:.|:..|.|.|..|::: .:
Worm    85 --AIARKTNKFNSKPNE--------QLRIFTKSCLDRKEMDEDTFQDLRNDIEERGGFPMID-PN 138

  Fly   156 WQEDDFDWLNTTARM----AHRYGIMSI----------------------------IGVGVATDF 188
            |.|:.||..:..|:.    .:|.|.:|:                            :|:.:..|
Worm   139 WNEEKFDLSDMLAKYLSINRNRMGFLSVEPYAAIEGNKSVNRLYVSPGPHWVYNWAMGISIYKD- 202

  Fly   189 ANNQKNIIYINQQEFPLKTRSMYMDNETAIYRQNYQNNIQLILEKYLGVKDELARKAAKEMFEFE 253
                 ::.::.::...|:.|.:   ||| ||.:.:...:||                 :..|...
Worm   203 -----SVAFMLRRLLKLENREL---NET-IYDKEFAELVQL-----------------EANFSTL 241

  Fly   254 VDLAHGLVDN---NKHLNLRDLIEL------LTVAELRERYAPTLDTDQLIFVSMGEKISDKVY- 308
            .|..:..:||   :|..||.||:::      :.:.:...|:. |.:.|:       ||:.::|.
Worm   242 ADYRNLALDNDNMSKSRNLTDLVKMIPEIDWIKILKALARHG-TSEEDE-------EKLLERVTV 298

  Fly   309 ----EYNRRYQQNLVEVIERTPKSTVANYLFLRLIWE----FIQKPSGVAEKPTE---------- 355
                ||.....:.|..:...||||.:||||.:|.:.:    |..|     ::|.:
Worm   299 HGAGEYFFGENRELARIATETPKSALANYLVVRQLIDVALYFYDK-----DQPRQNKFYNHVDQQ 358

  Fly   356 -ACVDFTKTYFAKNLDNMIYR--RYKNEKSSREIDSMWHQLKSTFKETLLSSPALDWIEPSTRSL 417
             .|.....::|.....|:...  ::|.| :.:.|:.|:.::|:.:::....:   :::|...|..
Worm   359 SFCATQVASFFPMPSMNVFIESSQFKIE-NLKVIEEMFVKIKAEYEQIFTEN---EYLELEIREF 419

  Fly   418 AIAKLEAMTLEVNNYVKENFTE-------EFADLNLQNTDCVENLRQVQMLQAKQMRQ------L 469
            .|.||.|:.   ..:..:.:||       .:..||..:||   :..||.|...:...:      :
Worm   420 LIRKLNAID---GKFGLDQYTEGKPLLEKMYETLNFLDTD---SPWQVYMKMWRHWSEQLVEHIV 478

  Fly   470 YHQPAKPLEA---GELLSYTPSNILLENSIKVPVALLQPFYIWSDV-YPNAVMFGTLAYLIGHEL 530
            :..|..|:..   |...:|.|    ..|...:.:..|.  |.|.|. :|....:|.|.|:||||:
Worm   479 HDTPLDPVNLKMFGTHAAYQP----YPNHFYINLPYLT--YPWMDADFPANTNYGYLGYVIGHEI 537

  Fly   531 IHGFDDSGRKFDEKGNSKDWW-DEKSSSN--FLKRRDCFTKQYGRYVYDGIQ--LKESTAQSENI 590
            .|.||...||.||.|..:.:| .|.:|||  :..|..|...||..|...|..  :..:..:.|..
Worm   538 GHAFDHFHRKLDESGRQQQYWFTETNSSNTEYELREKCLRDQYSAYKEPGYDFFMNGTHCRYEIA 602

  Fly   591 ADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKE---TLPNLRYTAKQLFFISFAQSWCNDVHPKV 652
            .|:.|:|.|:..:.|              :.||   .||.|..:.:||||.::|...|:..:|..
Worm   603 GDHMGIRTAFRVFEK--------------VKKEDRFRLPGLEMSEEQLFFYNYAFRQCDVYNPNK 653

  Fly   653 KALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKCILY 700
            ....:....|...::||.|.:.|..||::.|||...|.|||..||.||
Worm   654 LPRNMLARQHPTNRYRVNGVIQNIPEFAEAFNCPKNSPMNPEMKCKLY 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	169/734 (23%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	171/734 (23%)
nep-18	NP_494297.1	PepO	42..692	CDD:226118	169/733 (23%)
nep-18	NP_494297.1	M13	47..699	CDD:189000	172/735 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880