DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl20 and nep-8

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001309548.1	Gene:	nep-8 / 184631	WormBaseID:	WBGene00017553	Length:	686	Species:	Caenorhabditis elegans

Alignment Length:	739	Identity:	166/739 - (22%)
Similarity:	304/739 - (41%)	Gaps:	155/739 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KLFCIWIASHVLSVLVLAA---------PTSEDVLNQ-----------DTPYMKELMRQAKAAEI 48
            ||...|:|.::|.::|..|         |.:.|.|..           |:|....|     :.|:
Worm     9 KLSRPWVAVNLLLLIVFLAMVTVHIKVEPVNLDELLSIGNDVDSKNLCDSPECITL-----SHEL 68

  Fly    49 ESFMNQKVDPCKDFYAFSCGNYKRINSALNMRVLTTGVFETLTKGLNRKILKMLNTPHDSHDTPE 113
            .::.:..||||.||:..|||.:.. .|....|:      :.....|.::|.:.|:...:|....|
Worm    69 LNYQDPSVDPCVDFFQHSCGRFHE-QSVSESRL------QKKKHILRKQIREFLHKIQNSTSKSE 126

  Fly   114 DIQVKHFYESCLQIKEL-NSTYSEKLKR--------LIAEFGTMPLLEGSSWQEDDFDWLNTTAR 169
            :: :|..::.|...|:. |..|  |:.|        .|.:.|..|||: .:|....|| ||..
Worm   127 NL-MKLVFDKCEASKKTSNDNY--KISRDAIHDVFNDIKKIGAWPLLD-KNWDGSKFD-LNEM-- 184

  Fly   170 MAHRYGIMSIIGVGVATDFANNQKNIIYINQQEFP--LKTRSMYMDNETAIYRQNYQNNIQLILE 232
                  :.:::.:| ||:....|.:...:.:.:|.  ..|....:.|.|.|      :.|..|||
Worm   185 ------LSNLVKLG-ATNLGLFQLDFRILTEGKFVRIAPTLGSIVHNSTMI------SMISEILE 236

  Fly   233 KYLGVKDELARKAAKEMFEF---EVDLA----HGLVDNN----KHLNLRDLIELLTVAELRERYA 286
            .. ||:.: :.:.:||..|:   ::.||    .|.:..:    :.:|...||
Worm   237 AN-GVQPD-SEEISKEFEEYSSLQMKLAKYQSSGKLSISLPGVRSINFSSLI------------- 286

  Fly   287 PTLDTDQLIFVSMGEKISDKV----YEYNRRYQQNLVE----VIERTPKSTVANYLFLRLIWEFI 343
                 .::|..|...||..|:    .|:...::.|..|    :||.|...|:||:    ||:.:|
Worm   287 -----TEMIHPSRVSKIFGKIRVVTSEHPLFFKSNETESLDTIIESTSNKTLANF----LIFNYI 342

  Fly   344 QKPSGVAEKPTEA-CVDFTKTYFAKNLDNMIYRRYKNEKSSREIDSMWHQLKSTFKETLLSSPAL 407
            |....:.:..... |.|..:..|.:....:..|.:.::.:...:..:..:||   |.||......
Worm   343 QSSYNIMKGARRGNCEDDVRREFPRASLRVFMRNFVDKGNRDGVKKLTEELK---KNTLEMIQDT 404

  Fly   408 DWIEPSTRSLAIAKLEAMTLEVNNYVKENF------TEEFADLNLQNTDCVENL-RQVQMLQAKQ 465
            :.:.|..:...:.|:||:.:.:.  ..::|      .:||.:.:|.:||....: :::..|:::|
Worm   405 ENLAPPVKESMLKKVEAIKVTIG--YPDHFDPPGTLDKEFENFDLDSTDSYYRIFQKLNRLRSEQ 467

  Fly   466 MRQLY--HQPAKPLEAGELLSYTPSNILLENSIKVPVALL-QPFYIWSDV-YPNAVMFGTLAYLI 526
            ..:..  ..|..|::  |:|....:....:|::.|....| .||:   |: ||:.|......:||
Worm   468 QMEFIAGETPISPIK--EVLKVNANYKRSKNALTVFAPFLDDPFF---DITYPDYVNLFFSGFLI 527

  Fly   527 GHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRY---VYDGIQLKESTAQSE 588
            .||:.|..|.:|..:||.|...|....:..:.:.|:..|...||..|   || |.::..:.:.:|
Worm   528 AHEIGHSVDANGLGYDENGKPMDGIRLEHVTEYGKQGQCLVDQYDNYDDPVY-GKKMNGTHSINE 591

  Fly   589 NIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFF------ISFAQSWCND 647
            .|||..|..:.:.||:|...:::....|.:|:   .:..|.:..:.|.|      ||..:: ..|
Worm   592 IIADWVGHEVTWRAYKKMDTSKMLSLIGLKDI---NMDQLYFRVQSLLFCRERDTISLEET-LKD 652

  Fly   648 VHPKVKALQVSTDDHMPGKFRVIG 671
            |:|        ||:     |||.|
Worm   653 VYP--------TDN-----FRVNG 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	152/673 (23%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	152/667 (23%)
nep-8	NP_001309548.1	M13	76..664	CDD:341056	152/667 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920