DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl20 and nep-6

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_494537.1	Gene:	nep-6 / 184628	WormBaseID:	WBGene00017550	Length:	726	Species:	Caenorhabditis elegans

Alignment Length:	761	Identity:	171/761 - (22%)
Similarity:	292/761 - (38%)	Gaps:	165/761 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LAAPTS----EDVLNQDTPYMKELMRQAK--------------AAEIESFMNQKVDPCKDFYAFS 66
            |.||..    |.|.|..|....|.:.||.              |.::.:|.:..||||:|||..:
Worm    51 LVAPEKKSRPEPVTNPVTMTRPEPVTQASKPRNVCETPGCVTLADQLLNFQDPSVDPCQDFYKAA 115

  Fly    67 CGNYKRINSALNMRVLTTGVFETLTKGLNRKILKMLNTPHDSHDTPEDIQVKHFYESCLQIKE-- 129
            ||.|.. :...|.|:....:.      :.|.|...|.....|....|:: ::..|.:|..:|.
Worm   116 CGKYSE-HEVANRRLQKKDII------IQRMIKNFLLKNETSESKSENV-MRQVYRTCEGLKNEE 172

  Fly   130 -LNSTYSEKLKRLIAEFGTMPLLEGSSWQEDDFDWLNTTARMAHRYGIMSIIGVGVATDFANNQK 193
             .|:......:.|..:...:     .||...|.:|..|...:...  :::|:.:| :::|
Worm   173 IFNANMKTAFRELFKDIQKI-----GSWPAADKNWDETKLNLNEM--LLNIVKLG-SSNF----- 224

  Fly   194 NIIYINQQEFPLKTRSMYMDNETAIYRQNYQNNIQLILEKYLGVKDELARKAAKEMFEFEVDLAH 258
            .:..|...|.|....:..|.....: ..|:|..|..||||                        :
Worm   225 GLFQIRPTEVPFLEVAPDMARSPKV-SANFQQIIFDILEK------------------------N 264

  Fly   259 GLVDNNKHLNLRDLIELLTVAELRERYAPTLDTDQLIFVSMG--------EKISDKVYEYNRR-- 313
            || ..::::...|:.:.:|:.|...:||...:.:::.|..:.        |||.:::...||:
Worm   265 GL-QPDENVIADDVEDYITLEETLSQYAYDYNAEKVQFSKLQAQVPSLKLEKIIEEMMNPNRKKL 328

  Fly   314 -------------------YQQNLVEVIERTPKSTVANYL---FLRLIWEFIQKPSGVAEKPTEA 356
                               .:.||.::::.|||.|:||||   ::......:.....|.:|  ..
Worm   329 LVTKVKPRMVAHKHSLFFDEKMNLEKLLKSTPKRTLANYLIFYYMDHAMNGLSVHDNVIKK--RN 391

  Fly   357 CVDFTKTYFAKNLDNMIYRRYKNEKSSREIDSMWHQLKSTFKETLLSSPALDWIEPSTRSLAIAK 421
            |......|..|....:..|.:..:.:.:.:|.|..:.|.:|.|.|..|   .|:...::..||.|
Worm   392 CEKLVIEYLPKASLRVFVRNHFEKGNLKIVDEMAEETKKSFIEMLQES---TWLGADSKKNAILK 453

  Fly   422 LEAMTLEVNNYVKENFTEE------FADLNLQNTDCVENLRQVQMLQAKQMRQLYHQPAKPLEAG 480
            ||.|. ::..|.|| |.::      |..|.|...|.:..:       .|::.:.:.:......|.
Worm   454 LEKMG-KMIGYPKE-FEKKGALDKMFETLKLLPKDTLYGI-------LKKIGRFHMEQGIEFVAL 509

  Fly   481 ELLSYTPSNILLENSIKVPVALLQPFY----------------IWSDVYPNAVMFGTLAYLIGHE 529
            |    ||.:.:|      ||.:...||                ::...||..|.......::.||
Worm   510 E----TPMDPVL------PVLMTNAFYTDRNHLSFLVGYMDDPLFDATYPKYVNIALTGNILAHE 564

  Fly   530 LIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRY---VYDGIQLKESTAQSENIA 591
            ..||||.:|.|.||.|..:.|...:....:.|:..|...||..|   |: |..|..:|..:|.:|
Worm   565 TSHGFDTAGIKRDENGEVRSWMKPEDLKEYGKKTQCLVDQYNEYDDPVF-GKNLNGTTTLNEMVA 628

  Fly   592 DNGGMRLAYTAYRKWYENQLTLPNGAQDMTKE--TLPNLRYTAKQLFFISFAQSWCNDVHPKVKA 654
            |..|:.:|:..:.|            .|.:||  .:........:|:|.:.|..:|: :.|....
Worm   629 DMIGVTVAWKVFEK------------LDSSKEQKVIGFENENIDKLYFRAAALDFCS-LPPTTSL 680

  Fly   655 LQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKCILY 700
            ::..|..|..|.|||.|..||..:|:..|||..||.|||..:|.::
Worm   681 VEELTRVHPTGNFRVNGIFSNMPQFATAFNCPEGSPMNPKTRCSIF 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	156/702 (22%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	158/702 (23%)
nep-6	NP_494537.1	M13	105..724	CDD:189000	158/703 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6404
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.870