DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl20 and nep-22

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_509528.1	Gene:	nep-22 / 181144	WormBaseID:	WBGene00020788	Length:	798	Species:	Caenorhabditis elegans

Alignment Length:	826	Identity:	181/826 - (21%)
Similarity:	315/826 - (38%)	Gaps:	198/826 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IWIASHVLSVLVLA-APTSEDVLNQDTPYMKELMRQAKAAEIESF-------------------- 51
            |.|.|.||::::|. ..|....:|.:..|     ....|.::.|.
Worm    19 IAIGSLVLNIIILGNVNTLTTTVNNNPVY-----HYTPAPQVNSTPGTVNTSPSYTQAANYLLNG 78

  Fly    52 MNQKVDPCKDFYAFSCGNYKRINSALNMRVLTTGVFETLTKGLNRKILKMLNTPHDSHDTPEDIQ 116
            ::..||||:|||||:|..:.:......:.....|.::.....:..:|:..|:....:..|....:
Worm    79 LDDTVDPCQDFYAFTCNKFLQNTDLQKLGRSRLGTYDQAQVDVYSEIVAALSKIDVTSTTTSKTE 143

  Fly   117 --VKHFYESCLQIKELNSTYSEKLKRLIAE----FGTMPLLEGSSWQEDDFDWLNTTARMAHRYG 175
              .|..:|:|   |...::.::|...:.||    ||.:|.. |...:.:...|: ...::..::.
Worm   144 RITKAAFETC---KNNLASPADKTAVVYAEITSLFGGVPFF-GEPLKTNVDYWM-VAGQIEQKHA 203

  Fly   176 IMSIIGVGVATDFANNQKNIIYINQQEFPLKTRSMYMDNETAIYRQNYQNNIQLIL-------EK 233
            :.::.....::|:.::.||.:|.......| .|..|:..:.........:::..:|       :|
Worm   204 VGTLTYTIASSDYKDHTKNALYTGPPGLSL-ARDFYVKPQYIAEVNQRVSDVNDLLTAFANAAKK 267

  Fly   234 YLGVKDELARKAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRERY------------- 285
            .:|....||  ||:|:..|||.:|.....::...|.:.......:|.....|
Worm   268 NVGADALLA--AAQEVVNFEVQIAMASWPDDLLRNYQQQYNPYNIASATTAYRAINWKSYLGQLF 330

  Fly   286 -APTLDTDQLIFVSMGEKISDKVYEYN-----RRYQQNLVEVIE-RTPKST-VANYLFLRLI--- 339
             ....|.||.              .||     ..|...|..|.: :|..|| ||||:..:|:
Worm   331 HGVASDADQA--------------NYNIVVTEPSYFAWLNSVFDGKTSNSTVVANYMIAQLLADE 381

  Fly   340 WEFIQKPSGVAEKPT------------------------------EACVDFTKTYFAKNLDNMIY 374
            .:||...:......|                              |.|:|....|.... ...:|
Worm   382 SDFINPATAKVSSDTNYIHYALRNGRGIKKIGKREYRMADLDGISEGCMDLLTAYMPYG-TGYVY 445

  Fly   375 RRYKNEKSSREIDSMWHQLKSTFKETLLSS------PALDWIEPSTRSLAIAKL----------E 423
            .:.|:|::..:.|     :|.  :.||:.:      .:|:|::..:::.|..|.          |
Worm   446 VKSKSERNKVQAD-----VKD--QTTLIINNFQGMIDSLNWMDTFSKNRAHNKSDSLVKNFGWPE 503

  Fly   424 AMTLEVNNYVK-ENFTEEFA---DLNLQNTDCVENLRQVQMLQAKQMRQLYHQPAKPLEAGELLS 484
            ||..:.|::.. :.:.:::|   ||..::.:.:..:..| :.:..::|:.:....:|.:....|.
Worm   504 AMFGDFNDFTTVDAYNQDYASIIDLYTKDKNDIYGIFAV-LKKGMEVREFFRIMGEPADRTNFLQ 567

  Fly   485 --------YTPSNILLENSIKVPVALLQPFYIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKF 541
                    |.|.    .|||..|.|...|.| ::..||.|..|.......||||.||:||.|.:|
Worm   568 SPAMVNAWYQPE----RNSITFPYAAWNPPY-YNLNYPQAYNFAGQGGTGGHELTHGYDDEGVQF 627

  Fly   542 DEKGNSKD-------WWDEKSSSNFLKRRDCFTKQYGR----------YVYDGIQLKESTAQSEN 589
            ...|...|       |.|..|||.|:....|...|:..          :..:|     :|.|.||
Worm   628 GFNGELTDCSWNKCGWMDTNSSSGFIDMAQCVVTQFSTQCCPEKTGNIHCANG-----ATTQGEN 687

  Fly   590 IADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNL-RYTAKQLFFISFAQSWC------ND 647
            |||.||.:.||.:||::.   .|...|.::   :.||.| .||..|:|:|::..|||      |.
Worm   688 IADLGGQQAAYRSYRQYV---ATTRKGVEE---DRLPGLENYTPNQIFWITYGYSWCMKQSDANL 746

  Fly   648 VHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNP 693
            ||      |:.|:.|.|.:.|....:.:..||.|:|.|..||.|.|
Worm   747 VH------QLLTNPHSPAQCRTNQVMQDIPEFGKDFGCVRGSPMYP 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	169/779 (22%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	170/757 (22%)
nep-22	NP_509528.1	PepO	76..795	CDD:226118	170/764 (22%)
nep-22	NP_509528.1	M13	83..793	CDD:189000	170/757 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920