Protein Alignment Nepl20 and nep-22

DIOPT Version :10

• Sequence 1: NP_651645.1
• Gene: Nepl20 / 43412
• FlyBaseID: FBgn0039613
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_509528.1
• Gene: nep-22 / 181144
• WormBaseID: WBGene00020788
• Length: 798
• Species: Caenorhabditis elegans
• Alignment Length: 826
• Identity: 181/826 - (21%)
• Similarity: 315/826 - (38%)
• Gaps: 198/826 - (23%)

  Fly     8 IWIASHVLSVLVLA-APTSEDVLNQDTPYMKELMRQAKAAEIESF-------------------- 51
            |.|.|.||::::|. ..|....:|.:..|     ....|.::.|.
 Worm    19 IAIGSLVLNIIILGNVNTLTTTVNNNPVY-----HYTPAPQVNSTPGTVNTSPSYTQAANYLLNG 78

  Fly    52 MNQKVDPCKDFYAFSCGNYKRINSALNMRVLTTGVFETLTKGLNRKILKMLNTPHDSHDTPEDIQ 116
            ::..||||:|||||:|..:.:......:.....|.::.....:..:|:..|:....:..|....:
 Worm    79 LDDTVDPCQDFYAFTCNKFLQNTDLQKLGRSRLGTYDQAQVDVYSEIVAALSKIDVTSTTTSKTE 143

  Fly   117 --VKHFYESCLQIKELNSTYSEKLKRLIAE----FGTMPLLEGSSWQEDDFDWLNTTARMAHRYG 175
              .|..:|:|   |...::.::|...:.||    ||.:|.. |...:.:...|: ...::..::.
 Worm   144 RITKAAFETC---KNNLASPADKTAVVYAEITSLFGGVPFF-GEPLKTNVDYWM-VAGQIEQKHA 203

  Fly   176 IMSIIGVGVATDFANNQKNIIYINQQEFPLKTRSMYMDNETAIYRQNYQNNIQLIL-------EK 233
            :.::.....::|:.::.||.:|.......| .|..|:..:.........:::..:|       :|
 Worm   204 VGTLTYTIASSDYKDHTKNALYTGPPGLSL-ARDFYVKPQYIAEVNQRVSDVNDLLTAFANAAKK 267

  Fly   234 YLGVKDELARKAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRERY------------- 285
            .:|....||  ||:|:..|||.:|.....::...|.:.......:|.....|
 Worm   268 NVGADALLA--AAQEVVNFEVQIAMASWPDDLLRNYQQQYNPYNIASATTAYRAINWKSYLGQLF 330

  Fly   286 -APTLDTDQLIFVSMGEKISDKVYEYN-----RRYQQNLVEVIE-RTPKST-VANYLFLRLI--- 339
             ....|.||.              .||     ..|...|..|.: :|..|| ||||:..:|:
 Worm   331 HGVASDADQA--------------NYNIVVTEPSYFAWLNSVFDGKTSNSTVVANYMIAQLLADE 381

  Fly   340 WEFIQKPSGVAEKPT------------------------------EACVDFTKTYFAKNLDNMIY 374
            .:||...:......|                              |.|:|....|.... ...:|
 Worm   382 SDFINPATAKVSSDTNYIHYALRNGRGIKKIGKREYRMADLDGISEGCMDLLTAYMPYG-TGYVY 445

  Fly   375 RRYKNEKSSREIDSMWHQLKSTFKETLLSS------PALDWIEPSTRSLAIAKL----------E 423
            .:.|:|::..:.|     :|.  :.||:.:      .:|:|::..:::.|..|.          |
 Worm   446 VKSKSERNKVQAD-----VKD--QTTLIINNFQGMIDSLNWMDTFSKNRAHNKSDSLVKNFGWPE 503

  Fly   424 AMTLEVNNYVK-ENFTEEFA---DLNLQNTDCVENLRQVQMLQAKQMRQLYHQPAKPLEAGELLS 484
            ||..:.|::.. :.:.:::|   ||..::.:.:..:..| :.:..::|:.:....:|.:....|.
 Worm   504 AMFGDFNDFTTVDAYNQDYASIIDLYTKDKNDIYGIFAV-LKKGMEVREFFRIMGEPADRTNFLQ 567

  Fly   485 --------YTPSNILLENSIKVPVALLQPFYIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKF 541
                    |.|.    .|||..|.|...|.| ::..||.|..|.......||||.||:||.|.:|
 Worm   568 SPAMVNAWYQPE----RNSITFPYAAWNPPY-YNLNYPQAYNFAGQGGTGGHELTHGYDDEGVQF 627

  Fly   542 DEKGNSKD-------WWDEKSSSNFLKRRDCFTKQYGR----------YVYDGIQLKESTAQSEN 589
            ...|...|       |.|..|||.|:....|...|:..          :..:|     :|.|.||
 Worm   628 GFNGELTDCSWNKCGWMDTNSSSGFIDMAQCVVTQFSTQCCPEKTGNIHCANG-----ATTQGEN 687

  Fly   590 IADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNL-RYTAKQLFFISFAQSWC------ND 647
            |||.||.:.||.:||::.   .|...|.::   :.||.| .||..|:|:|::..|||      |.
 Worm   688 IADLGGQQAAYRSYRQYV---ATTRKGVEE---DRLPGLENYTPNQIFWITYGYSWCMKQSDANL 746

  Fly   648 VHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNP 693
            ||      |:.|:.|.|.:.|....:.:..||.|:|.|..||.|.|
 Worm   747 VH------QLLTNPHSPAQCRTNQVMQDIPEFGKDFGCVRGSPMYP 786

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	M13	56..697	CDD:341056	170/757 (22%)
nep-22	NP_509528.1	M13	83..793	CDD:341056	170/757 (22%)