Protein Alignment Nepl20 and nep-21

DIOPT Version :10

• Sequence 1: NP_651645.1
• Gene: Nepl20 / 43412
• FlyBaseID: FBgn0039613
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001360525.1
• Gene: nep-21 / 179925
• WormBaseID: WBGene00011794
• Length: 864
• Species: Caenorhabditis elegans
• Alignment Length: 730
• Identity: 197/730 - (26%)
• Similarity: 320/730 - (43%)
• Gaps: 141/730 - (19%)

  Fly    52 MNQKVDPCKDFYAFSCGNYKRINSALNMRVLTTGVFETLTKGLNRKILKMLNTPHDSHDTPEDIQ 116
            :|.|::||:|||.|:|||| .:|..|............:...||:::..||.:|..:::.|.|..
 Worm   189 LNSKINPCEDFYEFACGNY-GLNKNLPANKPLRHTISDVQSRLNKQVKSMLQSPISANEKPWDKV 252

  Fly   117 VKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQEDDFDWLNTTARMAHRYGIMSII- 180
            .|.:|:.||..:||.||..|.::.:....|..|.|||..|||....|....|.:.:..|:.::|
 Worm   253 AKGYYQKCLDEEELESTGVEAMRDIAKRIGGWPTLEGDKWQEWSHSWEEQIALVLNLTGVNAVIL 317

  Fly   181 GVGVATDFANNQKNIIYINQQEFPLKTRSMYMDNETAIYRQNYQNNIQLILEKYLGVKDELARKA 245
            .:.|..|.:|:.:::|.::|.::...:|..|:........:|| ..:..:....||....:|.|.
 Worm   318 EMAVTHDPSNSSRSVIELDQPKWGAGSRYPYLSGANDPMLRNY-TTLMKMTAVALGADPAIAEKE 381

  Fly   246 AKEMFEFEVDLAHGLVDN---------NKHLNLRDLIELLTVAELRERYAPTLDTDQLIFVSMGE 301
            ..|..|||:.|.:...|:         |....|..|..:...... |:|..|: ..:|:.:|...
 Worm   382 MNEAMEFELKLVNFSADDMVRRDPERGNNRFELWQLKSVFPFINF-EKYLKTV-FKELVALSPNH 444

  Fly   302 KISDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLI-----------------------WEFI 343
            .:..:..:|....|    .|::.|||..:|||:..||:                       ::|.
 Worm   445 TVIVREIDYFVGIQ----HVLQSTPKRVLANYISWRLVQGGPTGDYFSFSPFLPPSAREPFYQFK 505

  Fly   344 QKPSGVAEKPT----EACVD-------------FTKTYFAKNLDNMIYRRYKNEKSSREIDSMWH 391
            ...:|:...|.    |.||.             |.:.:|.|            |::.:::..:..
 Worm   506 ANQTGMFNSPPPDRWEDCVTLSVIMMDMPVGRLFVENFFEK------------ERAMKKMTELTS 558

  Fly   392 QLKSTFKETLLSSPALDWIEPSTRSLAIAKLE--------AMTLEVNNYVKEN------------ 436
            .||:.|.:.|   ..|||::..||..||:|..        .|.|..:.::::|
 Worm   559 YLKNEFIKQL---HVLDWMDEITRRRAISKANMIEYKSGFPMVLFNDTWMEKNWGMIIKPREYLL 620

  Fly   437 ----------FTEEFADLNLQNTDCVENLRQVQMLQAKQMRQLYHQPAKPLEAGELLSYTPSNIL 491
                      ||||.             ||..|.|.    |.::.|....::|    .|.|:|
 Worm   621 HLTIRVKLVRFTEEL-------------LRLDQPLD----RSMWFQSPAQVDA----YYAPNN-- 662

  Fly   492 LENSIKVPVALLQ-PFYIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKS 555
              |.:..|..::| ||....  .||.:.:|.:..:||||:.|.|||.|.::||.||..||||.::
 Worm   663 --NEMIFPAGIMQFPFLTLG--VPNYITYGMVGAVIGHEVSHAFDDQGGQYDEMGNLNDWWDAET 723

  Fly   556 SSNFLKRRDCFTKQYG--RYVYDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQ 618
            ...|:::..||.:||.  ..|...|.|....:..||||||||::.|:.||:.|..|       ..
 Worm   724 EEKFIEKTRCFVRQYENVHVVEADIHLNGQLSLGENIADNGGVKTAFNAYKAWKSN-------TT 781

  Fly   619 DMTKETLPNLR-YTAKQLFFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKE 682
            .:::..||..: :|::|:||:::|.:||:.|.||.....:.||.|.|.|:|.:..|.|..||:|.
 Worm   782 GISEPALPGFQNFTSQQMFFLAYANNWCSLVRPKHYIQIILTDVHAPSKYRAMIPLQNRPEFAKA 846

  Fly   683 FNCHAGSAMNPIEKC 697
            |.|..||.|||..||
 Worm   847 FQCPIGSPMNPERKC 861

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	M13	56..697	CDD:341056	193/724 (27%)
nep-21	NP_001360525.1	M13	193..862	CDD:341056	195/726 (27%)