DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl20 and nep-23

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_503004.2	Gene:	nep-23 / 178472	WormBaseID:	WBGene00013785	Length:	714	Species:	Caenorhabditis elegans

Alignment Length:	736	Identity:	176/736 - (23%)
Similarity:	305/736 - (41%)	Gaps:	148/736 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LNQDTP-YMKELMRQAK-----AAEIESFMNQKVDPCKDFYAFSCGNYKR--INSALNMR--VLT 83
            |.|..| ::|:.:.|..     |.::.::.:...|||.:||...||....  :.|.|..:  :|.
Worm    63 LEQHRPGHLKKNVCQTPECITLAHQLHNYHDPSADPCDNFYQSVCGKQHEHSLKSGLAKKHLILR 127

  Fly    84 TGVFETLTKGLNRKILKMLNTPHDSHDTPEDIQVKHFYESCLQIKELNSTYS------EKLKRLI 142
            ..:.||:|   |||:     ||....:.    :::.|:..|.:.:..||:..      ..:.|.:
Worm   128 NLIRETIT---NRKV-----TPTSKSEN----EMRKFHGICSKYQRANSSSDIAQQALRDIFRDV 180

  Fly   143 AEFGTMPLLEGS-SWQEDDF---DWLNTTARMAHR-YGIMSIIGVGVATDFANNQKNIIYINQQE 202
            ...|:.|  .|| :|.|.||   :.||...::..| :|:..|         :...::.:.|:.:|
Worm   181 QSIGSWP--AGSRNWNESDFNLNEMLNNLVKLGQRNFGLFQI---------SFKYRDQLLISAEE 234

  Fly   203 FPLKTRSMYMDNETAIYRQNY---QNNIQLILEKYLGVKDELARKAAKEMFEFEVDLAHGLVDNN 264
                            :|:||   :..|..|.|....|.|.:  :..|::..|.  ....|:.|:
Worm   235 ----------------HRRNYSKLEPTILNIFETNGLVPDRI--QLLKDLEGFA--SLEALLKNH 279

  Fly   265 KHLNLRDLIELLTVAELRERYAPTLDTDQLI--FVSMGE-----KISDKVYEYNRRY----QQNL 318
            .:|:..|.::...:.:|    .|::|...|:  .:|.|:     ||..|....|:..    ..||
Worm   280 YYLDNMDKMKPAVLDDL----VPSVDFMGLVKAMISPGKEHLMPKIELKTSVLNQTLFNDENMNL 340

  Fly   319 VEVIERTPKSTVANYLFLRLIWEFIQKPSG--VAEKPTE---ACVDFTKTYFAKNLDNMIYRRYK 378
            ..:|..|||.|:|||    ||:.||.....  |.|..::   .|.|...||..:....:..|.|.
Worm   341 EAIILDTPKRTLANY----LIFNFIDSSLDHLVFETTSQKGNTCEDKVITYLPRASLRVFIRNYV 401

  Fly   379 NEKSSREIDSMWHQLKSTFKETLLSSPALDWIEPSTRSLAIAKLEAMTLEVNNYVKENFTEE--- 440
             :|.:|::.:...:.......||:.:..  |::..::.||:.|:.||...:.   ..:|.|.
Worm   402 -DKENRDLITQLAEKTRIALHTLVQNST--WLKAESKQLALDKINAMGKMIG---YPDFFEPPGT 460

  Fly   441 ----FADLNLQNTDCVEN-LRQVQMLQAKQMRQLYHQ--PAKP-LEAGELLS--YTPSNILLENS 495
                |.:|||.::|.... |.:::....:|....:.:  |..| |...|:.:  |.|.|.|
Worm   461 LDGMFKNLNLDSSDTYYTALNKLERYFVEQKMDYFAEETPLDPDLRVFEMNAYYYIPGNQL---- 521

  Fly   496 IKVPVALLQPFY---IWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSS 557
                 ..|.||:   ::...||:.|.......:||||:.|.|.........:|. :.|...:..:
Worm   522 -----NFLAPFFDDPMFDSTYPDYVNIAMSGNIIGHEMGHAFGPHAILRTVRGR-EVWMKPEELA 580

  Fly   558 NFLKRRDCFTKQYGRY-------VYDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPN 615
            .:..|..|...||..|       |:||.::.:     |.:|||.|..:::..::     .|.|.|
Worm   581 EYESRAQCLANQYSEYDDPDFGRVFDGGKVID-----ELVADNIGREVSWKMFK-----SLDLTN 635

  Fly   616 GAQDMTKETLPNLRYTAKQLFFISFAQSWCNDVHPKVKALQVSTDDHMPGK-FRVIGTLSNFEEF 679
            ..:.:..|.     |...||:|...|.:.|.. | .::.|:.|.:...|.| |||.|..:|..||
Worm   636 ATRIIGFED-----YDIDQLYFRVGALTHCTP-H-AMRDLKGSIESSHPRKAFRVNGVYANLPEF 693

  Fly   680 SKEFNCHAGSAMNPIEKCILY 700
            ::.|||..||.|||.:||.::
Worm   694 ARAFNCPTGSPMNPRKKCDMF 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	165/698 (24%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	168/698 (24%)
nep-23	NP_503004.2	M13	96..711	CDD:189000	168/698 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920