Protein Alignment Nepl20 and nep-17

DIOPT Version :10

• Sequence 1: NP_651645.1
• Gene: Nepl20 / 43412
• FlyBaseID: FBgn0039613
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001254395.1
• Gene: nep-17 / 174996
• WormBaseID: WBGene00010070
• Length: 1589
• Species: Caenorhabditis elegans
• Alignment Length: 827
• Identity: 194/827 - (23%)
• Similarity: 315/827 - (38%)
• Gaps: 245/827 - (29%)

  Fly    18 LVLAAPTSEDVLNQDTPYMKELMRQAKAAEIESFMNQKVDPCKDFYAFSCGNYKRINSALNMRVL 82
            :|..||.:...:::...|...:...||:      :|..:|||.|||:::|||:.:..|....|.
 Worm   852 VVPEAPITSTNVDKMNAYQMAVDYYAKS------VNTAIDPCDDFYSYACGNFNQSVSFYTARA- 909

  Fly    83 TTGVFETLTKGLNRKILKMLNTPHDS------HDTPEDIQVKHFYESCL----------QI---K 128
                         :.::.|.....|.      :.:|...:.|..|.:||          ||   |
 Worm   910 -------------QNLVYMAQKLEDPTYQTTINSSPALKKEKQLYNACLTATASSQSEDQILISK 961

  Fly   129 ELNSTYSEKLKRLIAEFGTM-----PLLEGSSWQEDDFDWLNTTARMAHRYGIMSIIGVGVATDF 188
            ....|..:.||.||.:..|:     |.|..:....|...:|      :...||.::|...|.|.:
 Worm   962 NYIQTKVDDLKTLIGQDFTLVNGGAPKLPSAKQIGDALGYL------SFEQGIDTLISPLVDTYW 1020

  Fly   189 ANNQKNIIYINQQEFPLKTRSMYMDNETAIYRQNYQNNIQLILE--KYLGVKDELARKAAKE--- 248
            .:|.|..             .|::|..||...:.|.......:|  |||.:..::..:.|:|
 Worm  1021 IDNSKGY-------------QMFIDQNTAYLSKTYYQPAAWKIEKPKYLKMALDVVTRYAREQNI 1072

  Fly   249 ------------MFEFEVDLA--HGLVDNNKH-----LNLRDLIELLTVAELRE-----RYAPTL 289
                        :.::|.::|  :...||.:.     .||....:|:|.....:     .:||.
 Worm  1073 TLPAGASDLLSNVLDYEQNIAVKYSTDDNTRRQFQRSWNLTKTSDLVTKYNFMDWMTYLSHAPN- 1136

  Fly   290 DTDQLIFVSMGEKISDKVYEYNRRYQQNLVEV----------IERTPKSTVANYLFLRLIW---E 341
                    ::..||:|      ..||.:::||          ::::|:..| |.||:||:.   :
 Worm  1137 --------AVKAKITD------ANYQVSVMEVDRLTHFSADYLQQSPELLV-NLLFVRLLLGNAQ 1186

  Fly   342 FIQKPS---------------GVAEKPT----------------EACVDFTKTYFAKNL----DN 371
            :|  ||               |::.:.|                .||..     .|.||    :.
 Worm  1187 YI--PSYASAFRGMTDESIFLGLSRRKTIPNHIPPPNFDLEANGPACAS-----VANNLMQFANG 1244

  Fly   372 MIYRRYKNEKSSREIDSMWHQLKSTFKETLLSSPA----LDWIEPSTRSLAIAK----------- 421
            .::..|. ..:::::.::........|..:.|...    |||:.|.|:..|.||
 Worm  1245 RVFVDYM-YPTAQDVTNIRKSAGGIIKNVISSFQGMIDQLDWMAPDTKQKAYAKTVQIQQNIAFP 1308

  Fly   422 --LEAMTLEVNNY------------------VKENFTEEFADLNLQNTDCVENLRQVQMLQAKQM 466
              ::..||..|.|                  :|.|...::..||...||..:.|.|...:.|
 Worm  1309 DWIKNDTLLGNYYSTLVIADSDNFYDIYDKLIKFNIFVQYNQLNAAQTDRTDFLGQPGTVNA--- 1370

  Fly   467 RQLYHQPAKPLEAGELLSYTPSNILLENSIKVPVALLQPFYIWSDVYPNAVMFGTLAYLIGHELI 531
               ::||       ||           |||..|..:|.|.| ::..:|.::.:|.:..:.||||.
 Worm  1371 ---WYQP-------EL-----------NSITFPAGILVPPY-FNPNWPPSINYGGMGLVAGHELT 1413

  Fly   532 HGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYV------YDGIQLKESTAQSENI 590
            |||||.|.::...||...|.|:.|.:.|.....|...:|..:.      |....:|....|.|||
 Worm  1414 HGFDDQGVQWGPTGNLARWMDDNSMAGFKNMSQCVINEYSGFCPLNATNYSPNCVKGPQTQGENI 1478

  Fly   591 ADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNL---RYTAKQLFFISFAQSWCNDVHPKV 652
            |||||:..|:.||:         .:.:.|.....||:.   ::|..||||:||||.|| :|....
 Worm  1479 ADNGGVHAAFNAYK---------THQSLDGPDPRLPDRLFGQFTHDQLFFMSFAQVWC-EVRRTD 1533

  Fly   653 KAL--QVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKC 697
            .||  |:..|.|.|..:||.||:.||..|...|||..||...|.:.|
 Worm  1534 DALYTQIMVDPHSPSMYRVYGTIQNFPAFQTAFNCPLGSKSAPEQHC 1580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	M13	56..697	CDD:341056	186/787 (24%)
nep-17	NP_001254395.1	M13	112..831	CDD:341056
		M13	884..1581	CDD:341056	187/789 (24%)