Protein Alignment Nepl20 and nep-1

DIOPT Version :10

• Sequence 1: NP_651645.1
• Gene: Nepl20 / 43412
• FlyBaseID: FBgn0039613
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_496490.2
• Gene: nep-1 / 174787
• WormBaseID: WBGene00013926
• Length: 754
• Species: Caenorhabditis elegans
• Alignment Length: 741
• Identity: 190/741 - (25%)
• Similarity: 320/741 - (43%)
• Gaps: 93/741 - (12%)

  Fly    24 TSEDVLNQDTPYMKELMR---------QAKAAEIESFMNQKVDPCKDFYAFSCGNYKRINSALNM 79
            ||||....:|...:|...         |..:..::..:|..:|||.||:.::|..:  ::|....
 Worm    43 TSEDKTVGNTVVEEEKKTYTVGDSEGYQEASRLLQKSLNLSLDPCDDFFEYACRAW--VDSHPIP 105

  Fly    80 RVLTTGVFETLTKGLNRKIL---KMLNTPHDSHDTPEDIQ-VKHFYESCLQIKELNSTYSEKLKR 140
            ..||:....|.|:   .|:|   :.|...:.|..|.:.|. :|..|.:|:..::.|:..:..|..
 Worm   106 DDLTSYSQFTATR---EKVLAEMRKLYEDNTSIPTSKSIALIKQIYNTCMDTEKHNAVGARDLLE 167

  Fly   141 LIAEFGTMPLLEGSSWQEDDFDWLNTTARMAHRYGIMSIIGVGVATDFANNQKNIIYINQQEFPL 205
            .|..:|..|::....|:|..||.....:.......:......|.|.|..|..:.::..:|....|
 Worm   168 KIKTYGYWPMVHNEKWRESTFDLTKLLSNTIQSRDVSVFFDFGPAEDSRNVSRRLLSFDQGSLGL 232

  Fly   206 --KTRSMYMD-----NETAIYRQNYQNNIQLILEKY-LGVKDELARKAAKEMFEFEVDLAHGLVD 262
              .||..|:|     .:...||:.....::...|.. :.|.:........|:..||.:.|..||.
 Worm   233 GYSTRDYYLDEKKYEKQMKAYRKYTIGKVRYYTEDAGMAVNESKIESDVDEIIAFEKEWAQILVA 297

  Fly   263 NNKHLNLRDLIELLTVAELRERYAPTLDTDQL------IFVSMGEKISDKVYEYNRRYQQNLVEV 321
            .....|...|..:....:|:| |...:|..:|      ..|....|.:..:...:..|.|.:..:
 Worm   298 EEDRRNYTKLYNVRRFDDLKE-YMSIIDWKKLTLSTTPFLVHSYLKTNPSIIISDVEYLQKMNTL 361

  Fly   322 IERTPKSTVANYLFLRLIW-----------------EFIQKPSGVAEKPT--EACVDFTKTYFAK 367
            ::.|....|.||:.||  |                 ||..:..|..::..  :.||.......:.
 Worm   362 LQNTDPRIVTNYILLR--WAGSWSQEIGKKYEDLQQEFAFQMYGRKQRQPRWKDCVSSAGGKLSY 424

  Fly   368 NLDNMIYRRYKNEKSSREIDSMWHQLKSTFKETLLSSPALDWIEPSTRSLAIAKLEAMTLEVN-- 430
            ...:|..|:|.:..:......|...|:..|:..:   .|.||::..|:..|:.|.:.|..::.
 Worm   425 ASGSMYVRKYFDANAKNTTLDMITDLQEAFRNMM---HANDWMDAETKKYALEKADQMLKQIGYP 486

  Fly   431 NYV--KENFTEEFADLNLQNTDCVENLRQVQMLQAKQMRQ--LYHQPAKPLEAGELLS------- 484
            :::  .|...:.:..|.....|....|.:    ::.|.|.  .|.:..:|:...|.:|
 Worm   487 DFILNDEKLDDWYKGLEGAPEDSFSQLVE----KSIQWRNNFYYRRLLEPVNRFEFISSAAVVNA 547

  Fly   485 -YTPSNILLENSIKVPVALL-QPFYIWSDV-YPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGN 546
             |:|:    .|:|..|..:| |||:   |. :|.|:.:|.:..:||||:.|||||:||:||..||
 Worm   548 FYSPT----RNAIAFPAGILQQPFF---DARFPKALNYGGIGAVIGHEITHGFDDTGRQFDNVGN 605

  Fly   547 SKDWWDEKSSSNFLKRRDCFTKQYGRYVYDG--IQLKESTAQSENIADNGGMRLAYTAYRKWYEN 609
            .:||||..:||.|.:|..|..:||......|  :::.....|.||||||||::.|:.||:.:.|.
 Worm   606 LRDWWDNTTSSKFNERTQCIIEQYADVKLRGTDLRINGKLTQGENIADNGGIKQAFKAYKSYLEK 670

  Fly   610 QLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLS 674
                 :|.|:.......:|  |.:||||:.:||.||....|:.|.|.:.||.|.|...||...|:
 Worm   671 -----HGGQEARLPQFESL--TNEQLFFVGYAQVWCGAKTPETKTLLLLTDPHSPETARVNTVLT 728

  Fly   675 NFEEFSKEFNCHAGSAMNPIEKCILY 700
            |..||::.|.|.|||.|||.::|:::
 Worm   729 NQPEFAEAFKCPAGSPMNPTKRCVVW 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	M13	56..697	CDD:341056	181/695 (26%)
nep-1	NP_496490.2	M13	85..751	CDD:341056	181/694 (26%)