DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl20 and nep-1

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_496490.2	Gene:	nep-1 / 174787	WormBaseID:	WBGene00013926	Length:	754	Species:	Caenorhabditis elegans

Alignment Length:	741	Identity:	190/741 - (25%)
Similarity:	320/741 - (43%)	Gaps:	93/741 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 TSEDVLNQDTPYMKELMR---------QAKAAEIESFMNQKVDPCKDFYAFSCGNYKRINSALNM 79
            ||||....:|...:|...         |..:..::..:|..:|||.||:.::|..:  ::|....
Worm    43 TSEDKTVGNTVVEEEKKTYTVGDSEGYQEASRLLQKSLNLSLDPCDDFFEYACRAW--VDSHPIP 105

  Fly    80 RVLTTGVFETLTKGLNRKIL---KMLNTPHDSHDTPEDIQ-VKHFYESCLQIKELNSTYSEKLKR 140
            ..||:....|.|:   .|:|   :.|...:.|..|.:.|. :|..|.:|:..::.|:..:..|..
Worm   106 DDLTSYSQFTATR---EKVLAEMRKLYEDNTSIPTSKSIALIKQIYNTCMDTEKHNAVGARDLLE 167

  Fly   141 LIAEFGTMPLLEGSSWQEDDFDWLNTTARMAHRYGIMSIIGVGVATDFANNQKNIIYINQQEFPL 205
            .|..:|..|::....|:|..||.....:.......:......|.|.|..|..:.::..:|....|
Worm   168 KIKTYGYWPMVHNEKWRESTFDLTKLLSNTIQSRDVSVFFDFGPAEDSRNVSRRLLSFDQGSLGL 232

  Fly   206 --KTRSMYMD-----NETAIYRQNYQNNIQLILEKY-LGVKDELARKAAKEMFEFEVDLAHGLVD 262
              .||..|:|     .:...||:.....::...|.. :.|.:........|:..||.:.|..||.
Worm   233 GYSTRDYYLDEKKYEKQMKAYRKYTIGKVRYYTEDAGMAVNESKIESDVDEIIAFEKEWAQILVA 297

  Fly   263 NNKHLNLRDLIELLTVAELRERYAPTLDTDQL------IFVSMGEKISDKVYEYNRRYQQNLVEV 321
            .....|...|..:....:|:| |...:|..:|      ..|....|.:..:...:..|.|.:..:
Worm   298 EEDRRNYTKLYNVRRFDDLKE-YMSIIDWKKLTLSTTPFLVHSYLKTNPSIIISDVEYLQKMNTL 361

  Fly   322 IERTPKSTVANYLFLRLIW-----------------EFIQKPSGVAEKPT--EACVDFTKTYFAK 367
            ::.|....|.||:.||  |                 ||..:..|..::..  :.||.......:.
Worm   362 LQNTDPRIVTNYILLR--WAGSWSQEIGKKYEDLQQEFAFQMYGRKQRQPRWKDCVSSAGGKLSY 424

  Fly   368 NLDNMIYRRYKNEKSSREIDSMWHQLKSTFKETLLSSPALDWIEPSTRSLAIAKLEAMTLEVN-- 430
            ...:|..|:|.:..:......|...|:..|:..:   .|.||::..|:..|:.|.:.|..::.
Worm   425 ASGSMYVRKYFDANAKNTTLDMITDLQEAFRNMM---HANDWMDAETKKYALEKADQMLKQIGYP 486

  Fly   431 NYV--KENFTEEFADLNLQNTDCVENLRQVQMLQAKQMRQ--LYHQPAKPLEAGELLS------- 484
            :::  .|...:.:..|.....|....|.:    ::.|.|.  .|.:..:|:...|.:|
Worm   487 DFILNDEKLDDWYKGLEGAPEDSFSQLVE----KSIQWRNNFYYRRLLEPVNRFEFISSAAVVNA 547

  Fly   485 -YTPSNILLENSIKVPVALL-QPFYIWSDV-YPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGN 546
             |:|:    .|:|..|..:| |||:   |. :|.|:.:|.:..:||||:.|||||:||:||..||
Worm   548 FYSPT----RNAIAFPAGILQQPFF---DARFPKALNYGGIGAVIGHEITHGFDDTGRQFDNVGN 605

  Fly   547 SKDWWDEKSSSNFLKRRDCFTKQYGRYVYDG--IQLKESTAQSENIADNGGMRLAYTAYRKWYEN 609
            .:||||..:||.|.:|..|..:||......|  :::.....|.||||||||::.|:.||:.:.|.
Worm   606 LRDWWDNTTSSKFNERTQCIIEQYADVKLRGTDLRINGKLTQGENIADNGGIKQAFKAYKSYLEK 670

  Fly   610 QLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLS 674
                 :|.|:.......:|  |.:||||:.:||.||....|:.|.|.:.||.|.|...||...|:
Worm   671 -----HGGQEARLPQFESL--TNEQLFFVGYAQVWCGAKTPETKTLLLLTDPHSPETARVNTVLT 728

  Fly   675 NFEEFSKEFNCHAGSAMNPIEKCILY 700
            |..||::.|.|.|||.|||.::|:::
Worm   729 NQPEFAEAFKCPAGSPMNPTKRCVVW 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	179/695 (26%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	181/695 (26%)
nep-1	NP_496490.2	PepO	80..754	CDD:226118	183/702 (26%)
nep-1	NP_496490.2	M13	85..751	CDD:189000	181/694 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160145
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850