Protein Alignment Nepl20 and nep-26

DIOPT Version :10

• Sequence 1: NP_651645.1
• Gene: Nepl20 / 43412
• FlyBaseID: FBgn0039613
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001022540.1
• Gene: nep-26 / 174593
• WormBaseID: WBGene00014171
• Length: 807
• Species: Caenorhabditis elegans
• Alignment Length: 746
• Identity: 173/746 - (23%)
• Similarity: 306/746 - (41%)
• Gaps: 141/746 - (18%)

  Fly    45 AAEIESFMNQKVDPCKDFYAFSCGNYKRINSALNMRVLTTGVFETLTKGLNRKILKMLNTPHD-S 108
            |:.:...::|.|:||.:||.|:||.:  ||.::|::..:........:..:.:|::.::..:| |
 Worm   113 ASRLLKRVDQSVEPCDNFYQFACGGW--INQSVNLKYDSWNTLYETQRTAHDQIVQAMHKINDGS 175

  Fly   109 HDTPEDI---QVKHFYESCLQIKELNSTYSEKLKRLIAEF-GTMP-LLEGSSWQEDDFD------ 162
            :..|.:.   .....||.|:....|..|.....:|.:.|. |.|| |..|:..||:.|:
 Worm   176 YPLPTNAGERAAAKMYEQCMDTDTLEQTGLHLWERFVDELGGWMPELKNGALEQEESFEIELDED 240

  Fly   163 -------WLNTTARMAHRYGIMSIIGVGVATDFANNQKNIIYINQQ------------------- 201
                   .:......|..|.:..:...||..::.|:::::|.|.:|
 Worm   241 EKKRRRFEIEDIILSAFNYSVFPLFWAGVEVNYLNSKEHLITIYEQLPILLAPEKYHYNKELTPE 305

  Fly   202 ------EFPLKTRSMYMDNETAIYRQNYQNNIQLILEKYLGV--KDELARKAAKEM--FEFEVDL 256
                  |.|..||::....|.              |...||.  .||..|.....|  .|:::.:
 Worm   306 MIYGKMEGPPVTRALQQVGEE--------------LSAVLGFDSTDEKVRMMIANMIYLEYQITM 356

  Fly   257 AHGLVDNNKHLNLRDLIELLTVAELRE--RYAPTLDTDQLIFVSMGEKISDK---VYEYNRRYQQ 316
            |.......|.       |..||..|||  ..||.::....:...:||.:|..   ..:...::..
 Worm   357 AGSTFYKEKK-------ERYTVVMLRELQEIAPAINWHYFLSRLVGENLSHSEPIALKTGTQWIP 414

  Fly   317 NLVEVIERTPKS-----TVANYLFLR----------------LIWEFIQKPSGVAEKPTEACVDF 360
            .|..::|:..:|     .:.||:..:                |:|..:...||.|.:..|.||..
 Worm   415 ILSAIVEKLKQSRSGVAVLKNYVKWKTIMFHLAYASPKCRDGLLWMAVSLYSGAASQRKEFCVLR 479

  Fly   361 TKTYFAKNLDNMIYRRY----KNEKSSREIDSMWHQLKSTFKETLLSSPALDWIEPSTRSLAIAK 421
            ....|..:|.: |.|:.    ..||:.:.:.::..:::..::|.:.||....  :..||...|.|
 Worm   480 LSGIFPLSLPS-ILRKIDGIDHTEKNVKAVQNIADRIQEKYEEMVRSSNLFS--DRETRENVIDK 541

  Fly   422 LEAMTLEVN--NYVKENFTEEFADLNLQNT---DCVENLRQVQMLQAKQMRQLYHQPAKPLEAGE 481
            :..||..:.  :.::.::..|...:.|.:|   ..|.....|...:.:::| |...|...::...
 Worm   542 VNNMTKFIGFPDAMRSDYEMEKEAVRLHDTLFWSMVLGSSSVYKERLQRLR-LPVDPRSWVDTRP 605

  Fly   482 LLSYTPSNILLENSIKVPVALLQPFYIWSDV----YPNAVMFGTLAYLIGHELIHGFDDSGRKFD 542
            .:| .|::....|.:::|...|:..|  :|.    :.|....||   :|||||.|.||..|:...
 Worm   606 AIS-VPAHNYERNLVQIPFDSLRLPY--ADEHQLDFANYAGIGT---IIGHELTHAFDGQGKLHG 664

  Fly   543 EKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYV--YDGIQLKESTAQSENIADNGGMRLAYTAYRK 605
            ..||...||...|...|..|..||.|||...:  :|....||..  .|||||..|:::||.|::.
 Worm   665 PTGNLGVWWSTDSIREFKAREQCFVKQYAGLMDSHDMNAAKEGL--YENIADQVGLKVAYEAWKS 727

  Fly   606 WYENQLTLPNGAQDMTKETLPNL-RYTAKQLFFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRV 669
                     ||.|:..:  :|.| :|:..||||:::.|.||     .:::.......||..:.|:
 Worm   728 ---------NGNQNSGR--MPGLEKYSQDQLFFLAYTQGWC-----ALRSKSYKLQPHMEERIRM 776

  Fly   670 IGTLSNFEEFSKEFNCHAGSAMNPIEKCILY 700
            :|:|.|..||:..:.|.:.|.|||.:||.::
 Worm   777 LGSLQNSPEFASAWKCSSESFMNPPDKCSIW 807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	M13	56..697	CDD:341056	169/730 (23%)
nep-26	NP_001022540.1	M13	124..805	CDD:341056	170/731 (23%)