DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl20 and nep-12

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001364537.1	Gene:	nep-12 / 173824	WormBaseID:	WBGene00017842	Length:	832	Species:	Caenorhabditis elegans

Alignment Length:	718	Identity:	200/718 - (27%)
Similarity:	330/718 - (45%)	Gaps:	107/718 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 AAEIESFMNQKVDPCKDFYAFSCGNY--KRINSALNMRVLTTGVFETLTKGLNRKILKMLNTPHD 107
            ||...:.||:..:||:|||.|:||.|  :::.:....:|.   |...:.|.::|.:..:|.....
Worm   160 AASYLNNMNRDANPCEDFYEFACGKYATRKVIAEHEKKVT---VLSEMKKEMDRHLKDILEKTSR 221

  Fly   108 SHDTPEDIQVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQEDDFDWLNTTARMAH 172
            .:.|......:.:::||:.....:....:.|..:|:..|..|||..:.:...||.|......:|
Worm   222 ENTTRSMKLAQIYFDSCMDEFSQDDLGVQPLMSMISNLGGWPLLTNARFDSIDFQWEVLAGHLA- 285

  Fly   173 RYGIMSIIGVGVATDFANNQKNIIYINQQEFPLKTRSMYMDNETA-IYRQNYQNNIQLILEKYLG 236
            .||:..|..|.|.:.|.::.||::..:..:..|:.:..|.:..:: :|.|.|:..| |.|...||
Worm   286 LYGVDGIFRVFVHSSFDDSDKNVLMFSPPKLFLEKKKFYREVPSSNVYLQYYRQYI-LSLLSLLG 349

  Fly   237 V--KDELARKAAKEMFEFEVDLAHGLVDNNKHL----------NLRDLIELLTVAELRERYAPTL 289
            |  :||..      :.|::||   .::|..:.:          |...:..::|..|.:.:| ..:
Worm   350 VDMEDETG------VIEYQVD---DIIDFERRIANLTRIELSRNHSSINNMITFGEFKRKY-DKI 404

  Fly   290 DTDQLI-------FVSMGEKISDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLI-------- 339
            :.|...       ...|.:.:...|.:.|  |..||..:|:..|.|::.|:|...|:
Worm   405 NWDAFFNEEMRGNLGRMPDSLVINVVDVN--YFDNLYSLIKSKPLSSINNFLMWCLVSNYDMYLP 467

  Fly   340 -------WEFIQKPSGV-AEKPT-EACVDFTKTYFAKNLDNMIYRRYKNEKSSREIDSMWHQLKS 395
                   .:|.||..|| ::.|. |.||...:...|..|.....:::..:|.....:.|...||.
Worm   468 AKYRKPMLDFRQKMYGVSSDDPLWEVCVGEVRENLAMPLSTEYAQKFFTKKDKLVAEDMIRDLKK 532

  Fly   396 TFKETLLSSPALDWIEPSTRSLAIAKLEAMTLEVNNYVKENFTEE------FADLNL---QNTDC 451
            ..::|||::   |||:.|||..|:.||:||..::.  ..::...|      :|.:.|   |..|.
Worm   533 AMEQTLLNA---DWIDESTREAALMKLDAMGHKIG--FPDSLLNETAVLLPYAGVRLTANQYFDN 592

  Fly   452 VENLRQVQMLQAKQMRQLYHQP-----AKPLEAGELLSYTPSNILLENSIKVPVALLQ-PFYIWS 510
            ..:|::.....|  :.:|:..|     |.|:.|.:...|     ...|.|..|..:|| |.::
Worm   593 AISLKKAAYRDA--LSKLHRTPSLIDWASPIIAVDAFHY-----FTGNEIIFPAGILQFPMFV-- 648

  Fly   511 DVYPNAVMF---GTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGR 572
               |:|..|   |.:...||||:.||:||.|.::|:|||.:.||..::.:.|.|::.||..|||.
Worm   649 ---PDAPAFSNYGAIGMGIGHEITHGYDDLGAQYDDKGNLRGWWHTETMTTFQKKKQCFVAQYGS 710

  Fly   573 YV--YDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKET--LPNLR-YTA 632
            .:  ..|.::.......||||||||:|:|:.||      ||     ..|..|||  ||.|. ::.
Worm   711 KIEPQTGRKVDGKMTIGENIADNGGLRVAFQAY------QL-----RSDREKETRRLPGLTDFSP 764

  Fly   633 KQLFFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKC 697
            .||||:::|.:||..:.|......:.||.|..|.|||...|.|...|||||:|..||.|||.|||
Worm   765 NQLFFLAYANTWCEALKPSAIDHIMDTDVHSLGMFRVNVPLQNLPAFSKEFDCPIGSPMNPFEKC 829

  Fly   698 ILY 700
            .::
Worm   830 RIW 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	192/702 (27%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	194/702 (28%)
nep-12	NP_001364537.1	M13	171..830	CDD:341056	195/703 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880