Protein Alignment Nepl20 and nep-12

DIOPT Version :10

• Sequence 1: NP_651645.1
• Gene: Nepl20 / 43412
• FlyBaseID: FBgn0039613
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001364537.1
• Gene: nep-12 / 173824
• WormBaseID: WBGene00017842
• Length: 832
• Species: Caenorhabditis elegans
• Alignment Length: 718
• Identity: 200/718 - (27%)
• Similarity: 330/718 - (45%)
• Gaps: 107/718 - (14%)

  Fly    45 AAEIESFMNQKVDPCKDFYAFSCGNY--KRINSALNMRVLTTGVFETLTKGLNRKILKMLNTPHD 107
            ||...:.||:..:||:|||.|:||.|  :::.:....:|.   |...:.|.::|.:..:|.....
 Worm   160 AASYLNNMNRDANPCEDFYEFACGKYATRKVIAEHEKKVT---VLSEMKKEMDRHLKDILEKTSR 221

  Fly   108 SHDTPEDIQVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQEDDFDWLNTTARMAH 172
            .:.|......:.:::||:.....:....:.|..:|:..|..|||..:.:...||.|......:|
 Worm   222 ENTTRSMKLAQIYFDSCMDEFSQDDLGVQPLMSMISNLGGWPLLTNARFDSIDFQWEVLAGHLA- 285

  Fly   173 RYGIMSIIGVGVATDFANNQKNIIYINQQEFPLKTRSMYMDNETA-IYRQNYQNNIQLILEKYLG 236
            .||:..|..|.|.:.|.::.||::..:..:..|:.:..|.:..:: :|.|.|:..| |.|...||
 Worm   286 LYGVDGIFRVFVHSSFDDSDKNVLMFSPPKLFLEKKKFYREVPSSNVYLQYYRQYI-LSLLSLLG 349

  Fly   237 V--KDELARKAAKEMFEFEVDLAHGLVDNNKHL----------NLRDLIELLTVAELRERYAPTL 289
            |  :||..      :.|::||   .::|..:.:          |...:..::|..|.:.:| ..:
 Worm   350 VDMEDETG------VIEYQVD---DIIDFERRIANLTRIELSRNHSSINNMITFGEFKRKY-DKI 404

  Fly   290 DTDQLI-------FVSMGEKISDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLI-------- 339
            :.|...       ...|.:.:...|.:.|  |..||..:|:..|.|::.|:|...|:
 Worm   405 NWDAFFNEEMRGNLGRMPDSLVINVVDVN--YFDNLYSLIKSKPLSSINNFLMWCLVSNYDMYLP 467

  Fly   340 -------WEFIQKPSGV-AEKPT-EACVDFTKTYFAKNLDNMIYRRYKNEKSSREIDSMWHQLKS 395
                   .:|.||..|| ::.|. |.||...:...|..|.....:::..:|.....:.|...||.
 Worm   468 AKYRKPMLDFRQKMYGVSSDDPLWEVCVGEVRENLAMPLSTEYAQKFFTKKDKLVAEDMIRDLKK 532

  Fly   396 TFKETLLSSPALDWIEPSTRSLAIAKLEAMTLEVNNYVKENFTEE------FADLNL---QNTDC 451
            ..::|||::   |||:.|||..|:.||:||..::.  ..::...|      :|.:.|   |..|.
 Worm   533 AMEQTLLNA---DWIDESTREAALMKLDAMGHKIG--FPDSLLNETAVLLPYAGVRLTANQYFDN 592

  Fly   452 VENLRQVQMLQAKQMRQLYHQP-----AKPLEAGELLSYTPSNILLENSIKVPVALLQ-PFYIWS 510
            ..:|::.....|  :.:|:..|     |.|:.|.:...|     ...|.|..|..:|| |.::
 Worm   593 AISLKKAAYRDA--LSKLHRTPSLIDWASPIIAVDAFHY-----FTGNEIIFPAGILQFPMFV-- 648

  Fly   511 DVYPNAVMF---GTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGR 572
               |:|..|   |.:...||||:.||:||.|.::|:|||.:.||..::.:.|.|::.||..|||.
 Worm   649 ---PDAPAFSNYGAIGMGIGHEITHGYDDLGAQYDDKGNLRGWWHTETMTTFQKKKQCFVAQYGS 710

  Fly   573 YV--YDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKET--LPNLR-YTA 632
            .:  ..|.::.......||||||||:|:|:.||      ||     ..|..|||  ||.|. ::.
 Worm   711 KIEPQTGRKVDGKMTIGENIADNGGLRVAFQAY------QL-----RSDREKETRRLPGLTDFSP 764

  Fly   633 KQLFFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKC 697
            .||||:::|.:||..:.|......:.||.|..|.|||...|.|...|||||:|..||.|||.|||
 Worm   765 NQLFFLAYANTWCEALKPSAIDHIMDTDVHSLGMFRVNVPLQNLPAFSKEFDCPIGSPMNPFEKC 829

  Fly   698 ILY 700
            .::
 Worm   830 RIW 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	M13	56..697	CDD:341056	194/702 (28%)
nep-12	NP_001364537.1	M13	171..830	CDD:341056	195/703 (28%)