Protein Alignment Nepl20 and Mme

DIOPT Version :10

• Sequence 1: NP_651645.1
• Gene: Nepl20 / 43412
• FlyBaseID: FBgn0039613
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_032630.2
• Gene: Mme / 17380
• MGIID: 97004
• Length: 750
• Species: Mus musculus
• Alignment Length: 773
• Identity: 196/773 - (25%)
• Similarity: 341/773 - (44%)
• Gaps: 146/773 - (18%)

  Fly    15 LSVLVLAA-----------PTSEDVLNQDTPYMKELMRQAKAAEIESFMNQKVDPCKDFYAFSCG 68
            ||||||..           .|.:|.:.:.:..:|      .||.:...|:..|:||.||:.::||
Mouse    31 LSVLVLLLTIIAVTMIALYATYDDGICKSSDCIK------SAARLIQNMDASVEPCTDFFKYACG 89

  Fly    69 NYKRINSALNMRVLTTGVFETLTKGLNRKILK---------MLNTPHDSHDTPEDI----QVKHF 120
            .:.:.|.          :.||.::..|..||:         :|..|     ..|||    :.|..
Mouse    90 GWLKRNV----------IPETSSRYSNFDILRDELEVILKDVLQEP-----KTEDIVAVQKAKTL 139

  Fly   121 YESCLQIKELNSTYSEKLKRLIAEFGTMPLLE-------GSSWQEDDFDWLNTTARMAHRYGIMS 178
            |.||:....::|...:.|.:|:.:....|:..       |:||..:     .:.|::..:||...
Mouse   140 YRSCINESAIDSRGGQPLLKLLPDIYGWPVASDNWDQTYGTSWTAE-----KSIAQLNSKYGKKV 199

  Fly   179 IIGVGVATDFANNQKNIIYINQQEFPLKTRSMYMDNETAIYRQNYQNNIQLIL--------EKYL 235
            :|...|.||..|:.::||:.:|....|.:|..|  ..|.||::.....:..::        |:.|
Mouse   200 LINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYY--ECTGIYKEACTAYVDFMISVARLIRQEQSL 262

  Fly   236 GVKDELARKAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRERYAPTLD---------T 291
            .:.:........::.|.|.::|:.........:...|...:|:|:|:..::..::         |
Mouse   263 PIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEVNGKSFSWSNFT 327

  Fly   292 DQLI-FVSMGEKISDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLIWEFIQKPSGVAEKPTE 355
            :::: .|::..:..::|..|...|...|..::.:.....:.|.:..|.|.:.:   |.::....|
Mouse   328 NEIMSTVNINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLV---SSLSRNYKE 389

  Fly   356 ACVDFTK----------------TYFAKNLDNMIYRRYKNE----KSSREIDSMWHQLKSTFKET 400
            :...|.|                .|...|::|.:.|.|...    :|...::.:..|::..|.:|
Mouse   390 SRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQT 454

  Fly   401 LLSSPALDWIEPSTRSLAIAKLEAMTLEVNNYV--------KEN-FTEEFADLNLQNTDCVENLR 456
            |   ..|.|::..|:.    |.|...|.:...:        .|| ...|:.:||.:..:..||:.
Mouse   455 L---DDLTWMDAETKK----KAEEKALAIKERIGYPDDIISNENKLNNEYLELNYREDEYFENII 512

  Fly   457 Q-VQMLQAKQMRQLYHQPAKPLEAGELLS--------YTPSNILLENSIKVPVALLQPFYIWSDV 512
            | ::..|:||:::|    .:.::..|.:|        |:..    .|.|..|..:|||.: :|..
Mouse   513 QNLKFSQSKQLKKL----REKVDKDEWISGAAVVNAFYSSG----RNQIVFPAGILQPPF-FSAQ 568

  Fly   513 YPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYD- 576
            ..|::.:|.:..:||||:.|||||:||.|::.|:..|||.::|::||..:..|...|||.:.:|
Mouse   569 QSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFSWDL 633

  Fly   577 --GIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFIS 639
              |..|.......||||||||:..||.||:.:.:.     ||.:.:    ||.|....|||||::
Mouse   634 AGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKK-----NGEEKL----LPGLDLNHKQLFFLN 689

  Fly   640 FAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKC 697
            |||.||....|:.....:.||.|.||.||:||||.|..||:..|:|...|.|||..||
Mouse   690 FAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKC 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	M13	56..697	CDD:341056	182/719 (25%)
Mme	NP_032630.2	Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	77..748	CDD:341056	184/721 (26%)